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By: Jennifer Bui, Kathy luu , daniel miranda , tina yip

Characteristics of Immune Cells. By: Jennifer Bui, Kathy luu , daniel miranda , tina yip. PHM142 Fall 2014 Instructor: Dr. Jeffrey Henderson. Immune System. Innate Immune System. Physical Barriers Inflammation Complement System Immune Cells

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By: Jennifer Bui, Kathy luu , daniel miranda , tina yip

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  1. Characteristics of Immune Cells By: Jennifer Bui, Kathy luu, daniel miranda, tina yip PHM142 Fall 2014 Instructor: Dr. Jeffrey Henderson

  2. Immune System

  3. Innate Immune System • Physical Barriers • Inflammation • Complement System • Immune Cells • Neutrophils, eosinophils, basophils, macrophages, dendritic cells

  4. Leukocytes Basophils Eosinophils Neutrophils

  5. Cells Involved in Innate Immunity • Characteristics of Eosinophils • Stains Red • Receptors for IgE antibody • Responds to mainly parasitic infections • Granulocyte and Polymorphonuclear Leukocyte (PMN)

  6. Cells Involved in Innate Immunity • Characteristics of Basophils • Stains Purple/Blue • Cytoplasm filled with granules • Least Common • Contains Heparin • Contains Histamine • Granulocyte and PMN

  7. Cells Involved in Innate Immunity • Characteristics of Neutrophils • Most common leukocyte and has high motility • Attracted to site of infection by chemotaxins Site of Infection or Injury

  8. Cells Involved in Innate Immunity • Characteristics of Neutrophils • Performs phagocytosis • Destroys internalized microorganism with proteins from granules

  9. Macrophages Phagocytic cell – Ingest and destroy microorganisms

  10. Pattern Recognition Receptors (PRRs) Used to differentiate self from non-self Detect PAMPs

  11. Macrophages

  12. Dendritic Cells Long-finger like projections When immature – act as phagocytic cell

  13. Dendritic Cells

  14. B-cells Many surface proteins Very diverse -> nearly 1 billion different B-cells CD268 (BAFF-R) CD20 CD40 CD22 CD24 CD57 CD45R/B220 CD86 CD5 CD79a

  15. Antibody • Y-shaped protein • Recognize antigens • Variable region • Assembled via VDJ recombination Variable Region Fixed Region

  16. B-cell receptor (BCR) Distinguishes B-cells from other immune cells Allows B-cells to: recognize antigens & general signal Ligand binding Signal transduction

  17. Adaptive response 1. B-cell binds antigen 2. Antigen taken up and digested 3. Peptides presented on MHC II 4. Attracts T-cells

  18. B-cell differentiation Memory cell Plasma cell • Produce antibodies • Retain bound receptor for future

  19. T Cell Receptors (TCR) The antigen must be:1. degraded to short peptide sequences2. presented by APCs on MHC molecules

  20. CD4 (Helper) T Cells Activate macrophages Enhance inflammation Stimulate B cells to produce antibodies

  21. CD8 (Killer) T Cells Secrete cytotoxins and cytokines to kill infected cells

  22. Cross-presentation Extracellular material from infected cell is phagocytosed by APC to be presented on MHC class I

  23. References Mauri, C, Bosma, A (2012). "Immune Regulatory Function of B Cells". Annual Review of Immunology 30, 221–41. Murphy, K., & Travers, P. (2012). Janeway'simmunobiology (8th ed., p. 5-7, 11, 77, 78, 347, 348). New York: Garland Science. Owen, J., Punt, J., & Stranford, S. (2013). Kuby immunology (7.th ed., pp. 147-149). New York: W.H. Freeman. Parham, P. (2009). The Immune System (3rd ed., pp. 73, 79-81, 126, 133-134, 144-145, 227-228). New York: Garland Science. Silverthorn, D. U. (2012). Human Physiology: An Integrated Approach. (6th ed., pp. 131-134). New York: Pearson. Young, B., Lowe, J. S., Stevens, A., & Heath, J. W. (2006). Wheater's Functional Histology. (5th ed., pp. 20-23) Newcastle: Elsevier Limited.

  24. Summary slide

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