Welcome and Introduction to the Tenth Banff Conference on Allograft Pathology

1. Welcome and Introduction to the Tenth Banff Conference on Allograft Pathology Kim Solez, M.D. Lorraine Racusen, M.D.

2. A Very Great Pleasure to Welcome You to Our Tenth Conference Each conference is the best yet, this is no exception. Biggest conference yet with delegates from more than 30 countries including many represented for first time: Nigeria India Saudi Arabia Egypt Czech Republic Slovakia Hungary Croatia Oman

4. Transplantation in Pakistan.

5. Transplantation in Resource-limited Settings. Economies in operative procedure, donor and recipient operation done in same room. Economies in choice of imunosuppression. Economies in limited tissue typing approach. What about economies in pathology?

6. A PROBLEM LOOMING • When we incorporated immunostaining for C4d to detect antibody mediated rejection we began to exclude poor countries from the standard. • When we stuck with the technology of the 1950’s where the PAS stain was our most advanced technique the standard could be met in every country. • So suddenly it seems we had a standard that worked only for rich countries. • Need to find a mechanism for sharing pathology resources between rich and poor nations. • Need to proceed in parallel tracks, being mindful of what is the very best technology to use for greatest accuracy, and what is practical economically.

7. Program is most complete and varied we have ever had Excellent plenary and organ specific sessions. Program book lists all talks for concurrent sessions. Consult separate insert for organ specific schedule. Working lunches on BK nephropathy, chronic transplant glomerulopathy, and fibrosis scoring. White paper advance reading in areas of quality assurance, BK nephropathy, and fibrosis scoring. Focused heart session on antibody mediated rejection. Case presentations&posters with wine&cheese. On Friday back to Banff Centre where it all began!

8. We are very grateful to the organizing committee, and to session chairs. Organizing Committee:
Paula Blanco, MD
Mark Haas, MD
Michael Mengel, MD
Lorraine Racusen, MD
Banu Sis, MD
Kim Solez, MD Very grateful to all session chairs, directors of organ specific programs, and preparers of white papers and working lunches!

9. Social Events Gala Dinner 10 August 2009 (Monday) Music provided by Bel Canto Strings. Case Presentations with Wine & Cheese 11 August 2009 (Tuesday) Wildrose Prefunction area. Poster Presentations with Wine & Cheese 12 August 2009 (Wednesday) Wildrose Prefunction area.

10. Social Events (cont.) Banff Nature Tour 13 August 2009 (Thursday) Pick up and Drop off at the Rimrock Lobby. Field Excursion to Banff Centre 14 August 2009 (Friday) The Banff Centre: the original Banff Conference Location. Dinner and transportation to the centre will be provided.  Farewell Outdoor Barbecue Dinner at Banff Centre

11. Many thanks to Tori Sheldon and her team for administrative arrangements and setup! Darlene Nordstrom and Akshatha Raguveer also part of team. They will also take part in 2011 and 2013 meetings.

12. NEW SECTION OF BANFF WEBSITE ON HISTORY AND PROCEDURES • http://cybernephrology.ualberta.ca/Banff/history.htm • History and General information about the Banff Conferences on Allograft Pathology, the Banff Consensus Process and Funding

13. Publications from the banff meetings • New or revised schemas for diagnosis of allograft rejection/pathology – kidney, liver, pancreas, composite tissues • Consensus reviews and summaries related to graft pathology • Original investigations (often multi-center) arising from discussions and net-working at the Banff meetings

14. Authorship on Papers The author line in the manuscripts reflects the actual work of creating them, with the individuals who facilitate and structure discussions at the meeting and who actually write the paper being included first, and the other authors being listed alphabetically after that. Authorship includes everyone who provided substantive and useful input, even those who were not at the meeting. From the beginning we have favored participation by young people, and those from developing countries.  There has been a successful effort to make the classification truly international.

15. Working sessions – banff meetings • Ad hoc working sessions/interest group meetings have long been a feature of the Banff meetings – OPEN TO ALL • At recent Banff meetings, these have been more formalized, scheduled during the conference usually as working luncheons – OPEN TO ALL • Banff 2009- more of these organized consensus discussions scheduled, and more “up-front” planning – surveys, working document drafts – OPEN TO ALL

16. Education – banff meetings • Manuscripts have contributed to the medical literature, and provided guidelines for practice • “Banff up-dates” have become a feature of national and international meetings • Emphasis on young investigators – poster sessions added to the Banff meetings to provide additional forum for presentations by junior investigators as well as others, and optimal networking • Banff 2009- adding case discussions/reviews in real time to the Banff program • Planning a Banff Training Course in allograft pathology

17. Banff Training Course by 2013 We plan to establish a Banff Training Course by 2013 with Drs. Mengel, Sis, Blanco and Haas assisting us in assembling the documents and structure. Laurie Cat Bennett providing administrative support.

18. Funding Funding for the Banff meetings has been unusual in a very positive way from the very beginning: Those involved in organizing the meeting donate their time and are supported from elsewhere so there are essentially no administrative costs. Also from the beginning many speakers paid their own way to the meeting or found their own support; this has worked well for eighteen years and allows us to put on a consistently excellent, unique standard-setting meeting while keeping costs to a minimum. Funding for young people & those from countries not represented before is given priority.

19. Economic Considerations Affect Our Present and Future Meeting Plans Less ceremony this time, no town hall reception. This will be last time we can meet in place with “resort” in name. Very grateful to our local host for 2011 Paris Meeting Dr. Denis Glotz for his assistance in raising funds. Need to apply for grants again for 2011 and beyond, Drs. Mengel and Sis to undertake this. By 2013 need to be financially self sufficient. Meeting either in Brazil or in Quebec City, depending on financial confidence. 2015 meeting in Sweden. 2017 back in Banff.

20. The Banff Schema was first developed by a group of pathologists, nephrologists, and transplant surgeons at a meeting in Banff Canada August 2-4, 1991. The Banff Schema was first developed by a group of pathologists, nephrologists, and transplant surgeons at a meeting in Banff Canada August 2-4, 1991. We have come a long way! It has continued to evolve through meetings every two years and has become the worldwide standard for interpretation of transplant biopsies.

21. BANFF CONFERENCES ON ALLOGRAFT PATHOLOGY 1991-2027?

22. FUN TO THINK ABOUT THE NEXT EIGHTEEN YEARS! • Enjoy the conference and please let us have your comments and suggestions for the future. • Fill out evaluation forms! • Thanks to our sponsors!