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FLAIR Lesion Pre-Selection: Again

FLAIR Lesion Pre-Selection: Again. Last Time. Noticed a questionable aspect of the pipeline: normalizing values in a scan by the max SPM homogeneity correction is perhaps an alternate way to normalize the values across patients

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FLAIR Lesion Pre-Selection: Again

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  1. FLAIR Lesion Pre-Selection: Again

  2. Last Time • Noticed a questionable aspect of the pipeline: normalizing values in a scan by the max • SPM homogeneity correction is perhaps an alternate way to normalize the values across patients • The goal here is to create a lesion core pre-selection that is close to Hagen’s edited versions • We favor selecting too much over too little as this is easier to edit

  3. P009-Original FLAIR

  4. P009-SPM Normalized FLAIR

  5. P009-SPM Normalized FLAIR Lesions

  6. P009-Hagen’s Lesions

  7. P009-Max Normalized FLAIR Lesions

  8. P015-Original FLAIR

  9. P015-SPM Normalized FLAIR

  10. P015-SPM Normalized FLAIR Lesions

  11. P015-Hagen’s Lesions

  12. P015-Max Normalized FLAIR Lesions

  13. P028-Original FLAIR

  14. P028-SPM Normalized FLAIR

  15. P028-SPM Normalized FLAIR Lesions

  16. P028-Hagen’s Lesions

  17. P028-Max Normalized FLAIR Lesions

  18. Observations • SPM normalization usually gives a more conservative estimate, but not always as in P028 • Hagen did find himself removing a lot of material from the max normalized lesions so this is probably good • SPM normalization gives boundaries comparable to those edited by Hagen for the lesions is to does catch

  19. Conclusion • We would have to consult Hagen to see which he prefers to work from • My take: • Lesion boundaries are improved at the cost of missing some of the smaller focal lesions • I would switch to SPM normalization as I find that fine tuning boundaries is time consuming

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