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A new method to measure 10 B uptake in lung adenocarcinoma in hospital BNCT

A new method to measure 10 B uptake in lung adenocarcinoma in hospital BNCT. E. Capelli, P. Chiari. F. Basilico, P. Mauri. A. Zanini. D. Bolognini, E.M. Donegani, A. Mattera, M. Prest, S. Hasan. G. Giannini, E. Vallazza. P. Cappelletti, M. Frigerio, S. Gelosa, A. F. Monti. F. Borasio.

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A new method to measure 10 B uptake in lung adenocarcinoma in hospital BNCT

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  1. A new method to measure 10B uptake in lung adenocarcinoma in hospital BNCT E. Capelli, P. Chiari F. Basilico, P. Mauri A. Zanini D. Bolognini, E.M. Donegani, A. Mattera, M. Prest, S. Hasan G. Giannini, E. Vallazza P. Cappelletti, M. Frigerio, S. Gelosa, A. F. Monti F. Borasio Page 1

  2. Outline • BNCT • The INFN PhoNeS project • An innovative approach to Boron Imaging • Neutron Autoradiography • Measurements and results • Conclusion Page 2

  3. Boron Neutron Capture Therapy 10B (n,α,γ) 7Li binary technique high LET particles • BNCT could become useful for • highly-fatal tumours: • Extended (e.g. liver, lung) • Radioresistant (melanoma) • Localized near vital organs (glioblastoma) Page 3

  4. BORON CARRIERS NEUTRON SOURCES Difficulties for BNCT applications Low toxicity High specificity Non-persistence in the bloodstream High intensity thermal-epithermal neutron beam (5·108 n/cm2 s1) < 10 keV energy range Gamma contamination < 2 ·10-13 Gy cm2 / n BPA Page 4 BSH

  5. û Neutron Autoradiography • Nuclear reactor • Solid state track detector (CR 39) • Sometimes cryogenic temperature during the irradiation • Optic microscope for identification and count • Hospital-based neutron source • Real time detector Page 5

  6. PhoNeS (PhotoNeutronSource) Neutron flux in the treatment cavity: Φ= (1.3 ± 0.1) x 107 n cm-2 s-1 γ-contamination: reduced of 97% Page 6

  7. Real-time Neutron Autoradiography 0.5 cm CERROBEND photonconversion 6 cm PMMA thermalization • IRON BOX • Samples • Detector Neutron flux: Φ= (1.5 ± 0.1) x 105 n cm-2 s-1 Page 7

  8. The imaging detector Counts vs position Page 8

  9. The Data Acquisition System • UNDEPLETED silicon detector to detect α-particles from boronated samples down to 25 ng of 10B • INTER-BUNCH acquisition 18 MeV electrons Bunches of 5 μs Frequency 100 - 300 Hz Page 9

  10. The samples SOLUTION HOMOGENEITY SPECIMEN SUPPORT to prevent crystallization and self-absorption of the α-particles by the sample itself • plastic support (liquid solution) • evaporation • glass slide (blood samples) • coagulation process KNOWN VOLUME Drops of 5 μl Page 10

  11. Calibrating with BSH Integrated Spot Content (AU) vs Concentration (ppm) 500 MU/min –18 MV photons Varian CLINAC 2100 C/D, Sant’Anna Hospital (Como) Page 11

  12. The first ever kinetic curves Blood and urine of a patient administered BSH, taken at different times with respect to the administration. BLOOD URINE rescaled at the max value obtained by Si-autoradiography Special thanks to Dr.Sauerwein Page 12

  13. Ex-vivo lung perfusion in collaboration with “S.Luigi” Hospital in Orbassano (TO), Italy • Human lung affected by adenocarcinoma: • therapetic resection • perfusion of blood and BPA • Blood samples taken at different times: • to estimate 10B uptake Page 13

  14. Kinetic curves • Blood samples doped with BPA • Comparison between real-time autoradiography to MS analysis • The absorption takes place only in the first 90mins Page 14

  15. CR 39 10B concentration in tumour and healthy tissues of resected lobe High-resolution images to reproduce the features of the tissues Unhealthy tissue CT / CH~ 1.5 - 2 Healthy tissue Special thanks to Dr. Giannini Page 15

  16. Conclusions • Neutron Autoradiography in a hospital environment successfully performed - Linac • Development of an hospital-base neutron source to perform Boron Imaging with a 1D spatial resolution • Real-time detector to perform pharmacokinetic studies results during the irradiation • Blood samples from a perfused lung affected by adenocarcinoma kinetic curves - 10BPA down to concentrations of 5ppm • Evaluation of 10B concentration in tumour and healthy tissues Si-autoradiography – CR 39 • Looking forward to make BNCT possible in every radiotherapic unit Page 16

  17. A new method to measure 10B uptake in lung adenocarcinoma in hospital BNCT E. Capelli, P. Chiari A. Zanini F. Basilico, P. Mauri Thank you! G. Giannini, E. Vallazza F. Borasio P. Cappelletti, M. Frigerio, S. Gelosa, A. F. Monti D. Bolognini, E.M. Donegani, A. Mattera, M. Prest, S. Hasan Page 17

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