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Packaging of injections

Packaging of injections. Containers for injection ideal properties. Does not affect its contents No surface changes at temp. & pressure associated with sterilization Should protect from light when the contents are photosensitive

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Packaging of injections

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  1. Packaging of injections

  2. Containers for injectionideal properties • Does not affect its contents • No surface changes at temp. & pressure associated with sterilization • Should protect from light when the contents are photosensitive • Container should be cheap enough to dispose after one use or be easy to clean & reuse

  3. Contents should be easy to examine through the container to detect particles, contamination & decomposition

  4. Types of containers • Ampoules: single-dose glass containers with capacity of 0.5-50ml • Made from neutral or soda glass • Liberate gas particles on opening • Sealed by heat fusion to exclude MO • Used for solutions or powders

  5. Cartridges: cylindrical glass tubes sealed by rubber at each end • Holding slightly more than 1 ml • They are inserted into a metal syringe barrel • Used once

  6. Prepacked syringes: contain one dose of medication • No danger of particulate contamination due to glass

  7. Antibiotic vials & multiple-dose containers: • Rubber capped & allow withdrawal of a dose • Antibiotic vial vehicle is added to dissolve the powder • Multiple dose provide flexibility in the dose to be withdrawn • Greater risk of contamination

  8. Large volume fluids • Plastic or glass • Glass: thick walled & sealed with materials other than glass ( plastic, rubber with AL screw cap) • Plastic: unbreakable, light & disposable less transparent than glass, easily punctured, difficulty in estimating unused vol.

  9. Single dose vs. multiple dose

  10. Sterilization of injections • If possible, Injections should be sterilized in their final containers to reduce to a minimum the possibility of contamination

  11. Dry heat sterilization • Used for oily injections • Progesterone injection BP • Proyliodone injection BP is thermolabile so it is prepared by addition of the serile powder by aseptic techniques to arachis oil previously sterilized by dry heat

  12. Moist heat sterilization • Autoclaving is used for thermostable aq. Preparations • Closures may be sterilized by autoclaving them in solutions containing preservatives ( & medicaments) at concentarions twice those found in the injection

  13. Heating with a bactericide • For injections that are thermolabile to autoclaving • Not used for all routes

  14. Sterilization by filtration • Alternative to dry heat for oils • May avoid slight changes in heat sterilized products • Suitable for thermolabile stable aq. Preparations • Certain drugs may adsorb to filter

  15. Reconstitution by aseptic process at time of injection • Terminal sterilization with gaseous disinfectants may be used provided no chemical changes will happen in the drug • Ex. Erythromycin unharmed by this process

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