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Benefits of Carboplatin Injections

Is a chemotherapy drug used against some forms of cancer (mainly ovarian carcinoma, lung, head and neck cancers as well as endometrial, esophageal, bladder, breast and cervical; central nervous system or germ cell tumors; osteogenic sarcoma, and as preparation for a stem cell or bone marrow transplant).

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Benefits of Carboplatin Injections

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  1. What is Carboplatin? Is a chemotherapy drug used against some forms of cancer (mainly ovarian carcinoma, lung, head and neck cancers as well as endometrial, esophageal, bladder, breast and cervical; central nervous system or germ cell tumors; osteogenic sarcoma, and as preparation for a stem cell or bone marrow transplant). Landline : +91 - 22 - 6610 1752

  2. Indications and Usage The recommended dosage for previously untreated adults (normal renal function) is 400mg/m² as a single intravenous infusion over 15-60 minutes. Therapy should not be repeated again until four weeks have elapsed. In patients with risk factors such as previous myelosuppressive therapy or in the aged, the initial dosage may need to be reduced to 20-25%. Determination of the haematological nadir by weekly blood counts is recommended for adjusting future doses and scheduling of carboplatin. Landline : +91 - 22 - 6610 1752

  3. Patients with Impaired Kidney Function Patients with creatinine clearance values below 60 mL/min are at increased risk of severe bone marrow suppression. In renally-impaired patients who received single-agent carboplatin therapy, the incidence of severeleukopenia, neutropenia, or thrombocytopenia has been about 25% when the dosage modifications in the table below have been used. Landline : +91 - 22 - 6610 1752

  4. Side Effects Relative to cisplatin, the greatest benefit of carboplatin is its reduced side effects, particularly the elimination of nephrotoxic Nauseaand vomiting are less severe and more easily controlled. The main drawback of carboplatin is its myelosuppressive effect. This causes the bloodcell and platelet output of bone marrow in the body to decrease quite dramatically, sometimes as low as 10% of its usual production levels. This decrease in white blood cells(neutropenia) can cause complications, and is sometimes treated with drugs like filgrastim. Landline : +91 - 22 - 6610 1752

  5. Mechanism of Action Carboplatin is a cisplatin derivative and shares the same mechanism of action. Highly reactive latinum complexes are formed intracellularly. These complexes inhibit DNA synthesis through covalent binding of DNA molecules to form intrastrand and interstrand DNA crosslinks. Carboplatin is considered to be cell cycle phasenonspecific, but recent studies have shown complex and variable effects on the cell cycle. Landline : +91 - 22 - 6610 1752

  6. Contact Us Corp Office: Unit No.115, 1st Floor, Prabhadevi Industrial Estate, Swatantrya Veer Savarkar Road, Prabhadevi,Mumbai - 400 025. INDIA. Landline : +91 - 22 - 6610 1752Fax No: +91 - 22 - 6610 1753 info@labdhipharma.comlabdhipharma@gmail.com Landline : +91 - 22 - 6610 1752

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