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Adaptation and selection processes in emigration

Adaptation and selection processes in emigration. Scholars in exile Prague 25. May 2011. Ivan Lefkovits. University Hospital Basel. History. *Presov 1937 Ravensbrück, Bergen-Belsen 1944-45 Presov 1945 - 1948 Prague 1949 - 1965 Naples 1965 - 1967 Frankfurt 1967 - 1969

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Adaptation and selection processes in emigration

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  1. Adaptation and selection processes in emigration Scholars in exile Prague 25. May 2011 Ivan Lefkovits University Hospital Basel

  2. History *Presov 1937 Ravensbrück, Bergen-Belsen 1944-45 Presov 1945 - 1948 Prague 1949 - 1965 Naples 1965 - 1967 Frankfurt 1967 - 1969 Basel 1969 - present

  3. Niels K. Jerne Copenhagen 1943 Caltech 1954-5 WHO 1956 Pittsburgh 1962 Paul-Ehrlich-Institute 1966 Basel Institute for Immunology, Basel 1969

  4. Max Delbrück Caltech 1937 Vanderbilt 1939 Caltech 1947 Teaching in Köln after WW2 Caltech 1954 N.K.Jerne arrives at Max Delbrück’slaboratory Delbrück, Hershey & Luria one antibody molecule required to irreversibly neutralize one T4 phage Received Nobel Prize in 1969 • Charley Steinberg, Jim Watson, Richard Feynman

  5. Caltech 1955 N. K. Jerne The natural selection theory of antibody formation PNAS, November 1955 communicated byMax Delbrück • antibody specificities pre-exist • antigen selects the best fitting antibody

  6. Friday, November 3, 1967 Paul-Ehrlich Institute, Frankfurt

  7. EMBO course Frankfurt 1967

  8. Cell is precommitted to produce antibody of a single specificity

  9. Choose your project

  10. Your task: Build an institute: Start April 1969

  11. Hoffmann-La Roche establishes Basel Institute for Immunology Foundation Stone April 1969 Opening of the Institute First Part October 1970 Second Part April 1971

  12. 50 50 50 Scientists Technicians Auxilliary Personnel Basel Institute for Immunology horizontal structure 50 scientists 50 technicians 50 auxiliary personnel (animal unit, maintenance workshop, isotopes, library, secretarial help, cafeteria, etc) 10 permanent 50 scientists 40 time contracts Animal Caretakers Maintainance Workshop Isotopes Library Secretaries Cafeteria etc 40 10 permanent time limited members members

  13. Pioneers at BII the first wave Starting Group Scientists were generally interested in antibody specificity and its generation Selected scientists invited (Spring 1969) to a meeting at Hotel Krafft in Basel Many invitees from EMBO course (1967 Frankfurt) “If you come, I'll come too”

  14. BII members over 31 years

  15. Closing down BII June 2000 Jonathan Knowles of Roche announced termination of the BII “We are very proud of the achievements of the Institute” The Institute fulfilled its function. It cost “one billion CHF” over 30 years All contracts were honored December 2001: lights off

  16. Life continues University Hospital Basel January 2002 Holocaust memoires (Kontaktstelle für Holocaust-Überlebende)

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