1 / 18

MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII INFECTION IN RESPIRATORY INTENSIVE CARE UNIT

MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII INFECTION IN RESPIRATORY INTENSIVE CARE UNIT. Pervin Korkmaz Ekren 1 , M. Sezai Tasbakan 1 , Burcu Basarık 1 , Husnu Pullukcu 2 , Sohret Aydemir 3 , Alev Gurgun 1 , Ozen Kacmaz Basoglu 1 , Feza Bacakoglu 1.

astra-nolan
Download Presentation

MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII INFECTION IN RESPIRATORY INTENSIVE CARE UNIT

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII INFECTION IN RESPIRATORY INTENSIVE CARE UNIT Pervin Korkmaz Ekren1, M. Sezai Tasbakan1, Burcu Basarık1, Husnu Pullukcu2, Sohret Aydemir3, Alev Gurgun1, Ozen Kacmaz Basoglu1, Feza Bacakoglu1 Ege University School of MedicineDepartments of 1 Chest Diseases, 2Infection Disease and Clinic Microbiology, 3Microbiology and Clinic Microbiology

  2. Nosocomial Infections (1) • Multidrug-resistant (MDR) Gram-negative bacilli!!! • Acinetobacter baumannii : - Developing of antimicrobial resistance is extremely rapid - This resistance is multiple Serious therapeutic problems

  3. Nosocomial Infections (2) Acinetobacter baumannii: - Bacteremia - Urinary tract infection - Secondary meningitis

  4. Nosocomial Infections (2) Acinetobacter baumannii: - Bacteremia - Urinary tract infection - Secondary meningitis - Nosocomial pneumonia In intensive care units (ICU) Role in ventilator-associated pneumonia (VAP)↑

  5. Method • Ege University, Department of Chest Diseases • Respiratory ICU • December 2005 – December 2007 • 218 patients 58 patients (26.6% ) MDR A.baumanni Infection (-) MDR A.baumanni Infection (+) • 37 patients included in this study

  6. Table 1. Severity of diseases and characteristics of patients with MDR A.baumannii infections Results-1 Abbreviations: CAP= Community-acquired pneumoniae; NP= Nosocomial pneumoniae; COPD= Chronic obstructive lung disease; PIP= Pneumoniae at immunocompromised patients; TB= Tuberculosis; OSAS=Obstructive sleep apne syndrome; ARDS= “Acute respiratory distress syndrome”; APACHE II= “Acute Physiology and Chronic Health Evaluation”. *Causes of immunsuppresion: Haematological malignancy (4 cases), collagen vascular disease (2 cases), renal transplantation (1 case), renal failure (1 case)

  7. Results-2 • 31 patients ( 83.7 % ) Invasive mechanical ventilation • Patients with MDR A.baumannii infections; 24.3 % 59.5 % Pneumoniae 100 % of them

  8. Results-3 Figure 1. Rates of samples that MDR A.baumannii isolated (%) Abbreviations: ETA= Endotracheal aspiration; FOB= Fiberoptic bronchoscopy.

  9. Results-4 Table 2. Clinical characteristics of patients at the time of the MDR A.baumannii infections Abbreviations: ICU=İntensive care unit; VAP= ventilator-associated pneumonia; CRP= C-reaktive protein; SIRS= Systemic inflamatory response syndrome; ARDS= “Acute respiratory distress syndrome”. *mean±SD

  10. Results-5 Table 3. Risk factors at patients with MDR A.baumannii infections

  11. Results-6 Figure 2. Antibiotics that used at the time of MDR A.baumannii infections (%)

  12. Results-7 Drug-resistance to all antibiotics was observed in 62.2% of patients (%) Figure 3. Rates of antibiotic resistances for A.baumannii that isolated

  13. Results-8 Figure 4. Use of antibiotics for MDR A.baumannii infections Duration of antimicrobial therapy: 13.3±6.7 days (%)

  14. Results-9 Table 4. Characteristics, risk factors and prognosis of patients with/without MDR A.baumannii infections Abbreviatios: MDR= Multidrug resistant; ICU=Intensive care unit. * mean±SD

  15. Discussion (1) • Infections with A.baumannii in ICUs • Antibiotic resistance • VİP due toMDR A.baumannii; • antimicrobial therapy

  16. Discussion (2) • Pneumoniae withMDR A.baumannii • - prognosis is similar • - durations of ICU and hospital stays are • increasing

  17. Conclusions • In the our respiratory ICU • infections with MDR A.baumannii :% 26.6 % 59.5 VİP % 24.3 bacteraemia Drug-resistance to all antibiotics was Observedin 62.2% of patients

  18. Teşekkürler…

More Related