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ATP

OUTSIDE. P. P. P. P. MEMBRANE. INSIDE. Ras. AKAP. RAF. MEK. MAPK. ?. II. I. ROS. HCO 3 -. RECEPTOR TYROSINE KINASE. HCO 3- /Na + COTRANSPORTER. RECEPTORS LINKED TO NON-RECEPTOR TYROSINE KINASES. III. CYTOKINES/ GABA/ ANGIOTENSIN/ PROGESTERONE. Ca +.

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ATP

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  1. OUTSIDE P P P P MEMBRANE INSIDE Ras AKAP RAF MEK MAPK ? II I ROS HCO3- RECEPTOR TYROSINE KINASE HCO3-/Na+ COTRANSPORTER RECEPTORS LINKED TO NON-RECEPTOR TYROSINE KINASES III CYTOKINES/ GABA/ ANGIOTENSIN/ PROGESTERONE Ca+ (e.g.,EGF, IGF-1, p190 c-met, c-abl) CHOLESTEROL EFFLUX P P ADAPTER PROTEIN e.g.,shc HCO3- Na+ HCO3- ATP P + P ADP ATP Ca2+ sAC ? NON-RECEPTOR PROTEIN TYROSINE KINASE (e.g., c-yes, TK-32) ADP ATP cAMP + PPi ? C1 R1 Substrate R2 PKA C2 P Phosphorylated substrate PHOSPHOPROTEINS IDENTIFIED: • AKAP82 • pro-AKAP82 • FSP95 • CABYR • HSP90 • erp99 • HSP60 • FAI • FA-2/95kDa • Unidentified PROTEIN Ser/Thr PHOSPHORYLATION Protein tyrosine kinases ? PROTEIN TYROSINE PHOSPHORYLATION CAPACITATION

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