Research in the Emory School of Medicine

1. Research in the Emory School of Medicine David Stephens Jeff Sands Trish Haugaard October 2006

2. Emory University Hospital Yerkes Primate Research Ctr. GCRC VA-Research Ctr CRCA/MSCR/K30/K12 Crawford Long Hospital CDC Wesley Woods

3. Research progress at Emory SOM 1979: $105M Woodruff gift 1986: 5th strategic plan for research: goal - national prominance 1986: Juha Kokko, Chair Dept. Medicine 1988: Jeff Houpt, Dean 1990-95: 9 new chairs appointed; new space – Rollins Bldg & WRMB wing 1996: Tom Lawley, Dean; Mike Johns, VP WHSC 1997: 6th Strategic plan for research: goal – expand workforce 1996-05: 14 new chairs appointed; >160 new NIH-funded investigators 1996-05: new space: Vaccine Center, Whitehead, WCI, Pediatrics, Yerkes Neuroscience; lose space – A&P building 1999: Biomed. Engineering Department, Don Giddens Chair 2000: EmTec-Bio incubator 2003: 7th strategic plan for research: goal – team science 2005: capital campaign

4. Growth rate of NIH funding 1996-2005 benchmark Schools Ave. Annual Compound Growth Rate 1996 2005 RankSOM $ millions 19 15 9 13 5 2 4 1 17 11 18 7 Emory Univ. Vanderbilt Univ. Univ. of Pittsburgh Baylor College Duke Univ. Univ. of Penn. Washington Univ. Johns Hopkins U. Univ. of NC Stanford Univ. UAB Yale Univ. 55 71 99 89 128 149 162 204 104 132 98 159 190 244 288 257 350 399 378 449 217 264 191 298 14.8% 14.8% 12.6% 12.5% 11.9% 11.6% 9.8% 9.2% 8.6% 8.0% 7.7% 7.2%

5. Otolaryngology (3) Emergency Medicine (3) Surgery (8) Dermatology (9) Pathology & Lab Medicine (8) Neurology (11) Urology (11) Physical Medicine & Rehabilitation (14) Psychiatry & Behavioral Sciences (17) Neurosurgery (20) Top-20 ranked SOM departments (2005 NIH Funding) Clinical departmentsBasic science departments • Biomedical Engineering (1) • Microbiology & Immunology (7) • Pharmacology (11)

6. Selected recent achievements • 2003 • $16M for vaccine research (R Ahmed) • $12M for emerging infections and bio-defense • $10M + $7.6M for prostate metastasis study (L Chung, J Simons) • $7M for alcohol link to acute respiratory distress syndrome (M Moss) • 2004 • Chris Larsen “Roche Basic Science Award” by Amer. Soc. Transplantation • $4.9M to develop drugs for depression (C. Nemeroff) • 2005 • Top 10 “best work environment for postdocs” – The Scientist • $25M for cancer nanotechnology (S Nie) • $11.5M for cardiovascular nanomedicine (G Bao) • $9M for small molecule discovery (R Dingledine) • $7.4M for Alzheimer’s Center (A. Levey) • $525M received for sale of 3TC (D. Liotta, R. Schinazi)

7. Selectedrecentachievements 2006 • $7.5M to WCI Lung Cancer Research • $10M to Emory’s Transplant Center, Vaccine Center, and Yerkes for development of new vaccine strategies • 42 SOM investigators now have $1M+ in NIH awards • Vision 2012 – two new research buildings proposed • 1523 Clifton Road • As part of the new Medical Research Complex

8. Strategic Plans for Research

9. 2003 Strategic Plan for Research • Goal • Accelerate our progress towards top-tier status as a medical research enterprise • Mechanisms • Grow space, infrastructure and investigators • Promote translational & team science

10. Strategic Plan for Research: 2008 goals • Culture • Improve integration of research and clinical missions • People • Increase the number of NIH funded investigators by ~100 • Attend to retention as well as recruitment • Increase # grad students from 322 to ~500, MD/PhDs from 8% to 12% of entering class, and postdocs from 420 to 630 • Programs • Build new research space (550,000 gsf) • Build team science research from 18 to 25% of NIH income • Increase investment in enabling technologies & research cores

11. Seven Research Areas for Emphasis • Cancer • Neurosciences • Immunity and Host Defense • Cardiovascular and Epithelial Biology • Regenerative, Transplantation and Reparative Medicine • Integrative Medicine and Health Services Research • Molecular Structure and Interactions

12. Plan of Action for NIH RFA for Clinical and Translational Science Award (CTSA) The purpose of this initiative is to forge a uniquely transformative, novel and integrative academic home for clinical and translational science.

13. CTSA It should: 1. Captivate, advance and nurture a cadre of well-trained multi- and inter-disciplinary investigators and research teams. 2. Create an incubator for innovative research tools. 3. Synergize multi- and inter-disciplinary clinical and translational research.

14. CTSA • U54 Cooperative Agreement Mechanism • Application Due January 2007 • $6 million/yr. for 5 years total costs • 8 awards made in 2006 • NIH plans to award up to 60 awards by 2010-2012

15. Research Resources • Clinical Trial Office (Peter Block) • GCRC (Arlene Chapman) • Research core facilities • Microchemical and proteomics • BIMCORE • DNA sequencing • Flow cytometry • Microscopy • Animal imaging • Biomedical imaging technology MRI center • PET center • Transgenic mouse • Human tissue procurement & banking • Human embryonic stem cell

16. Additional SOM CORE FACILITIES • Animal Imaging • BIMCORE • Biomedical Imaging Technology Center • DNA Sequencing • Flow cytometry • Human Tissue Procurement & Banking • Microchemical & Proteomics • Microscopy • MRI Center • Positron Emission Tomography Center • Transgenic Mouse & Gene-Targeting

17. NEW CHALLENGES • NIH FUNDING • Budget growth shrinking • 90% of grant applications not funded • 1% across-the-board cut on all discretionary spending translating into a $286M reduction in NIH spending

18. NEW CHALLENGES • Grants.gov • Electronic Submission system not ready • SR424 very different than PHS398 • Change from % effort to # of person months • No internal electronic routing system (yet) • Earlier internal submission deadlines required

19. GRANT POINTERS • Submit your grant to multiple funding agencies, such as NIH, VA, AHA, others • Write your grant at least a month in advance of the deadline • Have people who know the field read it • Have people NOT in the field read it • Do not submit just to submit – it is better to get it right (or close) than to get triaged