RESEARCH in the Emory University School of Medicine October 28, 2010

1. RESEARCH in the Emory University School of Medicine October 28, 2010 Carolyn C. Meltzer, MD, FACR William P. Timmie Professor and Chair Associate Dean for Research and Ray Dingledine, PhD Professor and Chair of Pharmacology Executive Associate Dean for Research

2. Overview SOM Research Office • Research Resources and How to Find Them • Plans, Strategies, Challenges and Opportunities for Biomedical Research at Emory Over the Next 20 Minutes…

3. Research at Emory

4. School of Medicine Office of Research and Strategic Initiatives Ray Dingledine Exec Assoc Dean for Research Jeff Lennox Assoc Dean for Clinical Research Carolyn Meltzer Assoc Dean for Enabling Technologies Patricia Haugaard Assistant Dean for Research Admin Mary DeLong Assistant Dean for Postdoctoral Educatiom Mike Huerkamp Director of Animal Resources Chuck Elliott Director, SOM IT Kelly Shaw Project Coord. & AA support • SOM Cores: • Integrated EM • Flow cytometry • Transgenic mouse & gene targeting • Proteomics • Center for Systems Imaging • Bimcore Darryl Barr Associate Director Research Admin Sherie West Financial Analyst Michael Hart Assoc Chief of Staff for VAMC Research

5. Functions of the SOM Office of Research and Strategic Initiatives • Oversight of reporting units • Department of Animal Resources • Clinical Research Office (shared) • SOM IT • Post doc office • Management of research cores* • Policies and administrative support for • Research space management • Large grants, bridge funding, foundation award nominations • Compliance • Research Strategic Planning

6. NIH Funding Emory SOM 1996-2010 Annual growth of 11.7% over a 14 year period NIH Ranking 31 30 24 24 23 23 23 21 23 19 19 18 18 15 16(proj.) Source: NIH; *preliminary data; grants only

7. Alternative growth trajectories NIH grew 6.4% between 2003 and 2008

8. SOM Research Strategic Plan(co-chairs: Dingledine/Meltzer) Build on Research Mission to: CREATE innovative, collaborative discovery programs that ADVANCEhealth by prevention, early detection and treatment, and INSPIRE progress through medical research. 2009 Vision By 2015, Emory University School of Medicine will have had substantial impact on the understanding of human disease and enhancement of human health, and will be recognized as one of the top 10-15 research-intensive medical schools in the country.

9. SOM Research Strategic Plan(co-chairs: Dingledine/Meltzer) • Emphasis on • Partnerships – e.g. Georgia Tech, CDC, EHC • Infrastructure – decrease barriers • Achievement – “Mindshare”, Celebrate Gamechangers

10. Strategic approaches to vision Vision Enhance knowledge, Improve health 2009 Achievement, Infrastructure, Partnerships Team Science Top 10 in NIH awards 2003 Build Critical Mass Top 10 in NIH awards 1997

11. SOM Research Plan Strategic Initiatives • 1. Culture: Recognize Discovery & Achievement • Foster cultural shift from exclusive reliance on financial metrics to including identification of specific research achievements • 2. Research Infrastructure • Invest in growth and and integration of infrastructure: • Regulatory consolidation and administrative process improvement • Integration of IS systems in support of research • Sustainable core facilities • New research space needs • 3. Partnerships & Programmatic Growth • - Align and integrate clinical and research activities • - Further leverage unique partnerships to produce sustained competitive advantage in key areas • - Strengthen platform/enabling technologies

12. SOM Research Strategic Plan • Strengthen research core facilities • Provide both developing technologies and research service functions within core facilities • Implement sustainability planning in order to keep established cores innovative and competitive • Consider core models that provide access beyond the SOM (eg, university, regional or national consortia) • Provide incentives for the creation of successful value-added cores • Provide support for core-dependent grant applications

13. Comparing Apples to Apples:(or….When is a “Core” a Service Center?) • NIH Definitions: • Core • Shared piece of equipment or facility • No fees charged • Service Center • Shared equipment or facility for which fees are charged to support the cost of running the equipment or facility • Service Centers are subject to federal regulations (OMB circular A21) if any fees are paid from a federal grant or contract Most of the time when we use the term “core labs”, we are actually are referring to service centers

14. SOM Core Lab Facilities • Substantial revisions of the SOM Core Labs past 4 yrs • Many older facilities phased out depending on user base, revenue trends • More shared facilities • A 2006 SOM Research Core Resource Task Force: • Complementary constructs: • Service Cores • Emerging Technologies • Strengthened annual progress review process • Long term financial/strategic planning • RFA for new pilot cores (not implemented)

15. Current SOM Core Lab Facilities • SOM Cores • BIM Core • BITC • Flow Cytometry • Behavioral Core • Genomics Core • Affiliate SOM Cores (i.e., Shared support) • Transgenic Mouse Core (WCI) • Proteomics Core (Neurology) • Center for Systems Imaging (Radiology, WHSC, EU) • Robert Apkarian Electron Microscopy Facility (College)

16. Do We Really Have Only a Handful of Cores Available to SOM Faculty?

17. Purpose of the CTSAs U54 Consortium designed to transform how clinical and translational research is conducted, ultimately speeding bench-to-bedside translation of discoveries by: • Encouraging the development of new methods and approaches to clinical and translational research • Improving the training and mentoring to ensure that new investigators can navigate the increasingly complex research system • Designing new and improved clinical research informatics tools • Assembling interdisciplinary teams that cover the complete spectrum of medical research • Forging new partnerships with private and public health care organization

18. Goals of the ACTSI • Support cross-cutting scientific discovery, innovative initiatives, and their translation to humans through novel and emerging technologies • Establish a culture of community engagement and communication in clinical and translational research • Build upon, enhance, and expand successful education programs, clinical research curricula, mentoring, training, and career development

19. Interdisciplinary Programs and Strategic Themes of Atlanta-CTSI Emerging Technologies NANOTECHNOLOGY And DRUG DISCOVERY INFLAMMATION And Vaccines Animal Models and Imaging ACTSI PREDICTIVE HEALTH COMPUTATIONAL Life Sciences Health Disparities Regeneration and Repair

20. ACTSI’s Translational Technologies and Resources (TTR)) Program Enhance existing core capabilities Bridge funding (Coulter-like program in development) Proof-of-Principle Fund Rapid identification/acquisition of new technologies Support biomedical symposia Disseminate resource information Bridging technologies to translation Resource Web Portal Educational Programming Facilitate access to resources Provide training opportunities Access/Networks/Knowledge Dissemination Foster collaborations Support methods validation / development Pilot Studies Fund

21. TTR Proof-of Principle Fund • Georgia Research Alliance (GRA) Funds • Internal (Emory) Matching Funds • $200K per year • Proposed investments: • Biostatistics Core • New service core facilities • Sustainability for existing cores • “Valley of Death” funding • Coulter-like program (in development) • $500K per year • Annual RFA process • TTR Internal Advisory Committees reviews applications and makes recommendation

22. TTR Proof-of Principle Fund New Technology Investments To Date: • Deltavisiondeconvolution microscope • Next-generation sequencing core capabilities • Laboratory Information Management System (LIMS) hardware and software • Enhanced proteomics capabilities at Morehouse School of Medicine • Multispectral in vivo fluorescence imaging system for small animals • RainDance 1000 microdroplet generator (for multiplex PCR) • Carl Zeiss PALM System (for super-resolution molecular imaging) • Autoloader and fluidics station to upgrade the Affymetrics platform • Magnetic resonance spectroscopic (MRS) data analysis software

23. Imaging Animal models of humandisease Nanotechnology Drug Discovery and High-throughput technologies Genomics Immunology/ Vaccine ACTSI Translational Technology Program Focus Areas aligned with ACTSI themes

24. April 8, 2010 Featured Speaker Bernd Pichler, PhD Department of Radiology University of Tübingen A Unique Technology • MR/PET symposium a success!

25. Emory’s Approach to the “Access Barrier” • Core Newsletter • SOM and ACTSI Websites • eBIRT • electronic Biomedical Interactive Resource Tool • development supported through ACTSI • platform for context-based searching of research-related services and content to connect researchers to people and resources

26. Facilitating Discovery Biomedical Interactive Resource Tool (eBIRT) • First release version launched March 12th, 2010 • Includes lab services, equipment, material, software, training, and other resource types • 650+ unique visitors since March 2010 launch • Currently 54 core resources from across ACTSI institutions (and growing) • Roadmap for version 2 is under development • http://ebirt.emory.edu

27. Henry M. Blumberg, MD, Program Director • Master of Science in Clinical Research Program • CORE COURSES • Introduction to Clinical and Translational Research • Analytic Methods for Clinical and Translational Research I and II • Biostatistics • Data Management • Community Engagement/Health Disparities in Clinical Research • Clinical Trial Design and Analysis • Scientific and Grant Writing for Clinical and Translational Research • Fundamentals of Bioinformatics • Clinical Research Colloquium • Analysis of Clinical Research Data • Ethical, Legal, and Social Issues of Responsible Clinical Research • Rotation in the Clinical Interaction Network (CIN) • Rotation on the Institutional Review Board (IRB) • Electives include Behavioral Science and Health Education, Bioinformatics, Biostatistics, Epidemiology, Health Policy and Management, and Biology and Biological Sciences

28. NIH Grant Mechanisms • Career Development Awards (K-Series) • Research Grants (R-Series) • Research Training and Fellowships (T & F Series) • Program Project and Center Grants (P-Series) • Cooperative Agreements (U-Series)

29. Ethical Conduct of Research by Faculty • Authorship • Mentorship • Conflict of Interest • Disclosure vs reporting • Medical Professionalism • Informed Consent Resource through ACTSI website: http://www.atlantactsi.org/ “Ethical Dilemma of the Week”

30. Team Science Support through SOM • Up to $10K Team Science Support (“butt kicker”) • Bridge funding • Matching funds - individually assessed

31. Areas of Research Strength at Emory • Neurosciences • Vaccine – immunology – infectious disease • Cardiology • Transplantation – regenerative medicine • Rising quickly • Cancer • Drug discovery • Inflammation • Genetics • Informatics • Imaging

32. Research Resources • Clinical Research Office (Jeff Sands, Carlton Dampier, Robin Ginn) • CTSA (David Stephens) • Assistance with grant applications (Trish Haugaard) • Research core facilities (Carolyn Meltzer) (http://corelabs.emory.edu/) • Proteomics • Genomics • BIMCORE • Flow cytometry • Electron Microscopy • Center for Systems Imaging (MRI, PET) • Transgenic mouse • (29 other departmental or shared cores) • General information http://www.med.emory.edu/home/research/ora/index.html

33. Looking Ahead….

34. Summary