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Stem Cell Development Lesson 1

The Science and Ethics of Stem Cell Research. Stem Cell Development Lesson 1. Totipotent : Can become any cell in body or placenta. Pluripotent: Can become any cell in body. Totipotent stem cells. Multipotent: Can become any cell within a specific germ layer or cell lineage.

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Stem Cell Development Lesson 1

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  1. The Science and Ethics of Stem Cell Research Stem Cell Development Lesson 1

  2. Totipotent: Can become any cell in body or placenta Pluripotent: Can become any cell in body Totipotent stem cells Multipotent: Can become any cell within a specific germ layer or cell lineage Multipotent: Can become any cell within a specific germ layer or cell lineage Fate Decision Pluripotent stem cells (3-5 days old) Blastocyst Embryonic stem cells come from inner cell mass of blastocyst. Gastrulation (day 14) leads to Primary Germ Cells Endoderm (inner)gdigestive tract, resp. track Mesoderm (middle)gbones, blood cells, heart Ectoderm (outer)gskin, CNS Gastrulation (day 14) leads to Primary Germ Cells Endoderm (inner)gdigestive tract, resp. track Mesoderm (middle)gbones, blood cells, heart Ectoderm (outer)gskin, CNS Fate Decision Fate Decision Implantation Implantation An Overview of Early Developmentmodeled with Play-Dough Fertilized egg Multipotent

  3. What your zygote might look like:

  4. The Zygote

  5. What your morula might look like:

  6. Early Cell Division Source: Florida Institute for Reproductive Science and Technologies

  7. Four-cell stage2 days after fertilization Source: Florida Institute for Reproductive Science and Technologies

  8. Eight-cell stage3 days after fertilization Courtesy: RWJMS IVF Program Source: Florida Institute for Reproductive Science and Technologies

  9. Morula 4 days after fertilization16 cells Source: Florida Institute for Reproductive Science and Technologies

  10. What your blastula (blastocyst) might look like:

  11. Blastula5 days after fertilization Source: Florida Institute for Reproductive Science and Technologies Courtesy: RWJMS IVF Program

  12. Five Day Embryo http://www.nationalgeographic.com/ngm/

  13. Blastula (Blastocyst) This image has been released into the public domain.

  14. What your gastrula might look like:

  15. Sea Urchin Development One Cell to Blastula Stage • http://www.luc.edu/depts/biology/dev/urchindv.htm • (courtesy of Dr. J. Hardin, Univ. of Wisconsin) • http://www.exploratorium.edu/imaging_station/gallery.php?Asset=celldiv&Category=seaurchins&Type=video

  16. Early Mouse Development One Cell to Morula Stage

  17. Early Human Development

  18. Multipotent This graphic has been released into the public domain

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