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Experiment 2: Factors Affecting Drug Action

Experiment 2: Factors Affecting Drug Action. Influence of Route of Administration. 2C- Med’12 Subsection 2 Lim, Phoebe Llamas, Alay Lorenzo, Adrian Lim, Syndel Llego, Nasreen Lorilla, Richardson Lipana, Kirk Lopez, Camille Liu, Johanna Lopez-dee, Bernadette. Introduction.

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Experiment 2: Factors Affecting Drug Action

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  1. Experiment 2: Factors Affecting Drug Action Influence of Route of Administration 2C- Med’12 Subsection 2 Lim, Phoebe Llamas, Alay Lorenzo, Adrian Lim, Syndel Llego, Nasreen Lorilla, Richardson Lipana, Kirk Lopez, Camille Liu, Johanna Lopez-dee, Bernadette

  2. Introduction

  3. Routes of Administration • Intravenous drug administration • is the introduction of 100% of the drug into the systemic circulation ensuring that the drug administered is available for distribution to the target site. • Intramuscular route of administration • is directed in the muscles where it will be absorbed first before finally reaching the circulation and the target site of action.

  4. Introduction • Ketamine HCl • is an arylcyclohexylamine chemically related to phencyclidine (PCP) • a drug with a high abuse potential owing to its psychoactive properties. • MA: blocks the membrane effects of the excitatory neurotransmitter glutamic acid at the NMDA receptor subtype.

  5. Objectives General: • To determine how the route of administration influences the action of ketamine hydrochloride in rabbits. Specific: • To determine the dosage of ketamine hydrochloride to be administered to each rabbit by obtaining the weights (kg) of each animal. • To determine the latency (sec) and duration of action of Ketamine Hydrochloride injection when administered intravenously. • To determine the latency (sec) and duration of action of Ketamine Hydrochloride injection when administered intramuscularly.

  6. Objectives Specific: • To compare the latency and duration of action of Ketamine Hydrochloride injection when administered intravenously and intramuscularly. • To evaluate data obtained by using appropriate statistical test. • To statistically compare and determine any significant difference between the latencies of ketamine hydrochloride in the IV and IM administration via the paired T-test. • To statistically compare and determine if there was a significant difference between the durations of effect of ketamine hydrochloride in the IV and IM group via the paired T-test.

  7. Hypothesis 1st Hypothesis (Latency) • Null Hypothesis1: There is no significant difference between the latency (in sec.) observed with an intravenous injection and an intramuscular injection • Alternative Hypothesis1: There is a significant difference between the latency (in sec.) observed with an intravenous injection and an intramuscular injection

  8. Hypothesis 1st Hypothesis (Duration of Action) • Null Hypothesis1: There is no significant difference between the duration (in sec.) observed with an intravenous injection and an intramuscular injection • Alternative Hypothesis1: There is a significant difference between the duration (in sec.) observed with an intravenous injection and an intramuscular injection

  9. Methodology A B C D

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