1 / 37

Gene Panel Training session

Gene Panel Training session. Valairat Dhamcharee , M.D. Diplomate American Board of Medical Genetics Diplomate American Board of Neonatal Perinatal Medicine Diplomate American Board of Pediatrics. Take a more active role in managing your health. Goal.

azra
Download Presentation

Gene Panel Training session

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Gene PanelTraining session ValairatDhamcharee, M.D. Diplomate American Board of Medical Genetics Diplomate American Board of Neonatal Perinatal Medicine Diplomate American Board of Pediatrics

  2. Take a more active role in managing your health

  3. Goal • 1. Be on the lookout for common conditions • 2. Prepare for serious diseases • 3. Prevention of the unforeseen threats • 4. Make better lifestyle choices Valairat Dhamcharee, M.D.

  4. Target group: All age Test: Genetic markers Method: Saliva collection by Saliva kit

  5. Benefits • Early detection • Prevention • Treatment • Possible reversal of age-related disorders Valairat Dhamcharee, M.D.

  6. Categories of Testings • 1. Cardiovascular • 2. Metabolic • 3. Eye and vision • 4. Degenerative disorders • 5. Bones and joints • 6. Cancers • 7. Carrier status • 8. Drug response and side effects Valairat Dhamcharee, M.D.

  7. Cardiovascular • Abdominal Aortic Aneurysm • Atrial Fibrillation • Heart Attack • Hypertension • Peripheral Arterial Disease • Venous Thromboembolism Valairat Dhamcharee, M.D.

  8. Metabolic • Obesity • Type 1 Diabetes • Type 2 Diabetes Valairat Dhamcharee, M.D.

  9. Eye and vision • Age Related Macular Degeneration Valairat Dhamcharee, M.D.

  10. Degenerative disorders • Alzheimer’s Disease • Essential Tremor • Multiple Sclerosis Valairat Dhamcharee, M.D.

  11. Bones and joints • Gout • Rheumatoid Arthritis • Osteoarthritis Valairat Dhamcharee, M.D.

  12. Cancers • Basal Cell Carcinoma • Bladder Cancer • Breast Cancer • Colorectal Cancer • Lung Cancer • Ovarian Cancer • Pancreatic Cancer • Prostate Cancer • Testicular Cancer • Thyroid Cancer Valairat Dhamcharee, M.D.

  13. Male testings • Cardiovascular • Metabolic • Eye and vision • Degenerative disorders • Bones and joints • Cancer: Prostate, testicular Valairat Dhamcharee, M.D.

  14. Female testings • Cardiovascular • Metabolic • Eye and vision • Degenerative disorders • Bones and joints • Cancer: Breast, ovarian • SLE Valairat Dhamcharee, M.D.

  15. Carrier Testing • Thalassemia • Metabolic disorders Valairat Dhamcharee, M.D.

  16. Drug Response • Alcohol Consumption • Smoking and health risk • Antidepressant Response • Beta-Blocker Response • Caffeine Metabolism Valairat Dhamcharee, M.D.

  17. What we are testing to determine a genetic risk? • We are looking at “SNP” (Single Nucleotide Polymorphism) or “Genetic marker”. Valairat Dhamcharee, M.D.

  18. Genetics is who we are • Most of your physical traits, such as eye color, hair color, and height, are inherited. So, too, are risks for health problems, such as heart disease, diabetes, and some cancers. • In fact, all diseases or medical conditions have a genetic component (except trauma). Valairat Dhamcharee, M.D.

  19. What are we made of? Valairat Dhamcharee, M.D.

  20. How important is DNA? • Your DNA affects every aspect of your health by helping to shape your risks for many different health conditions. • DNA is 99.9% identical among humans. • All our variations of shape, size and color are within that remaining 0.1% (DNA variants). Valairat Dhamcharee, M.D.

  21. Human DNA Valairat Dhamcharee, M.D.

  22. Genetic (DNA) Variants • Each of us is different because we carry a unique combination of genetic variants. • These DNA variants have been analyzed and found that some of these DNA variants affect our risk of developing diseases, such as cancer, heart attack and diabetes. Valairat Dhamcharee, M.D.

  23. DNA Variants = SNPs • A SNP, pronounced “snip”, is a single variation in the nucleotide sequence of DNA and stands for Single Nucleotide Polymorphism that can affect our inherited risk and a multitude of other characteristics. Valairat Dhamcharee, M.D.

  24. DNA Variants (SNPs) Valairat Dhamcharee, M.D.

  25. DNA Variants (SNPs) Valairat Dhamcharee, M.D.

  26. Genetic Marker (SNP) • When a DNA variant is shown to be correlated with such a characteristic, this SNP can be referred to as a genetic marker for that disorder. Valairat Dhamcharee, M.D.

  27. Personalized Genetic Test • Your genetic profile can indicate your potential genetic risk • It is in your genetic makeup that you can discover your predisposition for various conditions and diseases. • Once you are aware of those conditions, taking preventive measures is the next logical step. Valairat Dhamcharee, M.D.

  28. Goals of Genetic Markers Analysis • Predictive • Preventive • Personalized Valairat Dhamcharee, M.D.

  29. How do we collect DNA sample? Valairat Dhamcharee, M.D.

  30. What happened to my DNA? • Labs will extract DNA from the cells found within saliva. • Analysis of DNA for SNPs. • The sample will be destroyed no more than 60 days after results are finalized. • DNA extract will be destroyed no more than one year from the most recently ordered report sample receipt date. • Request at any time that DNA be destroyed after testing Valairat Dhamcharee, M.D.

  31. Results • Available in 4-6 weeks Valairat Dhamcharee, M.D.

  32. Genetic counseling is required before and after testings Valairat Dhamcharee, M.D.

  33. What can you do if you have genetic risks? • Supplements • Lifestyle change Valairat Dhamcharee, M.D.

  34. How do you know if I do the right thing? • Telomere test to measure telomere length Valairat Dhamcharee, M.D.

  35. How to prevent and follow the change results? • Genetic counseling for detail to prevent the disorders screened to be at risk • Follow the result by “Telomere test” Valairat Dhamcharee, M.D.

More Related