E N D
1. Module 4
Caring for Children with Alterations in Hematologic/Immunologic
Chapter 26
2. The Hemopoietic System Anemia's
What causes alterations in hemopoietic/immunological systems?
acute blood loss
long-term nutritional deficit
acute/chronic systemic disease
genetic disorders
3. Assessment - Child’s History Dietary
nutritional assessment
food choices low iron content
Frequent infections
Exercise/play tolerance
level of frustration
02 capacity
attention span
Pain
Bleeding that is difficult to control
4. Physical Exam Integumentary
petechiae
ecchymosis
hematomas
Color
pallor look at conjunctiva, sclera, mucous membranes
jaundice
5. Physical Exam Cardiovascular
capillary refill
tachycardia
arrhythmias
peripheral pulses
Respiratory
signs of CHF
6. Physical Exam Musculoskeletal
joint enlargement
Lymphatic
lymph node swelling
G.I
tenderness
hepatosplenomegaly
7. Screening and Diagnostic Tests CBC
RBC’s - #of red blood cells
hemoglobin/hematocrit
MCV - mean corpuscular volume
reflects average size of each RBC - microcytic, normocytic or macrocytic
MCH - mean corpuscular hemoglobin
the average hemoglobin content in each RBC
8. Screening and Diagnostic Tests Platelet count - ability to clot
Reticulocyte count - # of young RBC’s
WBC
need to look at differential
neutrophils - fight bacterial infection
bands - immature neutrophils
lymphocytes - help develop antibodies and delay hypersensitivity
monocytes - clean up
eosinophils - increased in allergic responses
basophils - allergic responses
9. Screening and Diagnostic Tests Other Labs
Serum Ferritin - Iron storage protein
measured to assess the adequacy of iron reserves
TIBC - total iron-binding capacity
amount of available transferrin for binding more heme
FEP - free erythrocyte protoporphyrin
iron combines with proptoporphyrin to form heme
10. Screening and Diagnostic Tests
Peripheral blood smear
abnormalities in shape and size of cells
Occult blood
looking for bleeding
Hemoglobin electrophoresis
differentiates the various types of hemoglobin
Bone marrow aspiration
look at development of blood cells
site posterior iliac crest
11. Red Blood Cell DisordersAnemia Two Categories
1. Those resulting from impairment in production of RBCs
2. Those resulting from increase destruction or loss of RBCs
Clinical sign/symptoms
related to the decrease in the oxygen-carrying capacity of the blood
12. AnemiaSigns/symptoms Initially are non-specific
pallor
irritability
weakness
anorexia
decreased exercise tolerance
lack of interest in surrounding
Mild anemia
asymptomatic or symptoms on exertion
13. AnemiaSigns/symptoms Severe Anemia
skin is waxy, sallow in appearance
cardiac decompensation and CHF
Hgb 7-8g/100ml
cardiac compensatory adjustments occur
pallor of the skin and mucous membranes
14. AnemiaSigns/symptoms Sign of CHF
tachycardia
tachypnea
SOB
dyspnea
edema
hepatomegaly
Infants may exhibit few s/s with a hgb 4-5g/100ml
15. Anemia - Nursing Care Assessment
v/s, I & 0
urine
dip stick urine
specific gravity
stool
occult blood
examine skin for signs of petechiae
16. Anemia - Nursing Care shock
tachycardia
pallor
agitation
thirst
confusion
Nutritional Needs
calorie count
daily wt.
17. Anemia - Nursing Care
Food high in iron - especially with iron deficiency anemia
green leafy vegetables
eggs, organ meats
cereals fortified with iron
Hydration - especially with sickle cell
18. Anemia - Nursing Care Infections
major problem with blood dyscrasias
handwashing
protective isolation
v/s. - esp. the temp
rest periods
meet needs promptly
good skin care
Anxiety r/t hospitalization
Transfusions - blood and or platelets
19. Iron Deficiency Anemia Most common between the ages of 12-36 months and growth spurt in adolescence
Possible causes
insufficient supply of iron
impaired absorption of iron
Assessment
detailed diary of dietary foods and amounts
20. Iron Deficiency Anemia Labs
CBC, Serum Ferritin, TIBC, FEP, Reticulocyte count
Treatment
dietary education and change
be sensitive to cultural foods and beliefs
changes take time and need support
decrease milk intake
21. Iron Deficiency AnemiaTreatment Iron supplement
therapeutic levels
give between meals with orange juice
stains teeth - temporary
stools changes - tarry green
poisonous in improper dosage
22. Red Blood Cell DisordersSickle Cell Anemia Hereditary disorder characterized by abnormal type of hemoglobin - Hgb S
Sickling phenomenon - crisis
takes place when oxygen tension in blood is lowered
triggers
infection
dehydration
exposure to cold
stress - physical or emotional
24. Sickle Cell Anemia Sickling
RBCs sickle and clump together under low oxygen tensions causing a jamming effect in small vessels leading to tissue ischemia
Signs/symptoms
Infancy
frequent infections
failure to thrive
25. Sickle Cell AnemiaSigns/symptoms irritability
pallor
hepatospenomegaly
jaundice
growth retardation
Older Children
pain
joint, back and abdominal
26. Sickle Cell AnemiaSigns/symptoms nausea and vomiting
frequent infections
esp. respiratory tract
All areas of the body are involved
soft tissue swelling
joint swelling - pain
organs suffer serious complications from tissue ischemia leading to infarction
liver failure
kidney failure
27. Sickle Cell AnemiaTreatment rest to decrease oxygen consumption
pain management
hydration
oxygenation
protection from infection
prophylactic penicillin
acute infection
IV antibiotics
28. Sickle Cell Anemia Nisha is a 14 yr. Old, lives her her mother and grandmother. Is enjoying her summer breaks, likes softball, shopping with girlfriends and movies.
Mom brings her into the hospital c/o severe pain following pitching 7 innings in a softball game.
VS T 99.7 HR 110, RR 30, B/P 96/70, Sat 89%
Wt. 50Kg
CBC wbc 12,000 hgb & hct 9 and 24, platelet 140,000
What are your impressions of these values?
29. Discuss the pathophysiology of sickle cell anemia
What happens in crisis?
What other assessment data would be helpful in developing her nursing care plan?
What are your nursing diagnosis?
30. What do you think about the following orders?
VS q4 hr, notify if T >100.4
Reg dt
B/R with BSC
CBC with diff in am, UA and C/S, CXR
D5% 1/2NS at 175ml/hr
PCA - MS 1.5mg/hr with 1mg q 8min prn
Tyl 650mg po q4hr prn T >100.4
02 2L keep sat >94%
31. What nursing interventions are appropriate in meeting Nisha needs?
Four days later, pain is at 1/10, Nisha is up in chair, sitting quietly, sad facial expression.
How will you approach her?
What are her teaching priorities for discharge?
32. Hemophilia Group of bleeding disorders
inherited
deficiency of clotting factor
Signs and Symptoms
bleeding anywhere from or in body
hemarthosis
hematomas
excessive bruising, minor injury
hematuria
33. Hemophilia Treatment
replace clotting factor
prevent bleeding
RICE
Prognosis
no cure
control symptoms - normal life span
34. Neoplastic DisordersLeukemia Malignancy of unknown cause affecting the blood-forming organs
Acute Lymphocytic Leukemia
most prevalent in children
unrestricted proliferation of immature WBCs
Signs/symptoms
fever
abdominal pain
35. LeukemiaSigns/symptoms bone pain
anorexia
lethargy, malaise
pallor
hepatoplenomegaly
lymphadenopathy
petechiae, ecchymosis
36. Leukemia 4 major problems associated with diagnosis and treatment of leukemia
1. Anemia
2. Infection
3. Hemorrhage
4. Leukemic invasion
CNS involvement
increased ICP, meningeal irritation, n/v, lethargy, H/A, seizures
37. LeukemiaDiagnosis Established by a stained peripheral blood smear and bone marrow aspirate
cells in the marrow are precursor cells to those in the periphery
normal marrow elements are replaced with abnormal cells
38. LeukemiaTreatment Chemotherapy
set protocols
common side effects
anorexia, n/v
alopecia
infection
bone marrow depression
mucous membrane ulceration
39. LeukemiaNursing Care High Risk for Infection
reverse isolation
skin care
nutrition
sterile technique
central line - port-a-cath
labs
ANC (absolute neutrophil count)
multiple #WBC by % of neutrophils
40. LeukemiaNursing Care PC: Hemorrhage
assess skin for bleeding
dip stick urine
guaiac stool
guaiac emesis
bleeding gums
v/s
monitor labs
41. Nursing Care Hematological Precautions
no rectal temps
no rectal medications
no injections
no visits to playroom
labs
platelet count
42. Nursing Care Assess for complications of anemia
bleeding
CHF
hypotension
changes in behavior
43. LeukemiaNursing Care Altered Nutrition
small frequent meals
foods child likes and are nutritious
attractively served
keep child company while eating
clean environment
good oral hygiene
44. LeukemiaNursing Care Anxiety: child and family
therapeutic communication
good listener
encourage family to help
allow them some control
use play therapy
anticipate grieving
45. Leukemia Case Study Ashlee is 4-yr old who lives with her parents and 2 older siblings. She is very active, plays outdoors, rides tricycle, family’s jungle gym and goes to pre-school.
During the past 2 months Ashlee has been less active and begun to take 1-2 naps in the afternoon. Mom thinks she looks pale, takes her temperature, it is elevated so they go to the pediatrician. She has an upper respiratory tract infection, Dr. is concerned about possible leukemia so she is admitted to the hospital.
46. What diagnostic tests would your expect to be ordered?
Admission vital signs and labs are as follows:
T 100.4, HR 120, RR 28, B/P 100/60
CBC
RBC 4.6
WBC 4,000
Hgb & hct 11 and 31
Platelets 130,000
Differential neutrophils 1,600 monocytes 290
lymphocytes 1,200 eosinophiles 120
basophiles 30
47. Tests confirm a diagnosis of acute lymphocytic leukemia, what is this?
Ashlee’s Mom is crying at the bedside, “how can God let this happen” “how can I make it go away.”
How will you respond to her?
What are the nursing priorities of care for Ashlee?
Discuss the appropriate nursing interventions.
Discuss the factors that affect Ashlee’s prognosis.
48. Chemotherapy regimen is started
Zofran 2.5mg IV prior to chemo and then q4hrs for 24 hrs.
Dexamethasone 16mg IV prior to chemo
Ativan 1mg IV q4hrs for break thru nausea
Discuss Ashlee’s level of growth and development and how her treatment may impact this.
How can you work with Ashlee’s parents to help prevent complications associated with her growth and development?