PHYSIOLOGICAL DIFFERENCES by SEX with EXERCISE

1. PHYSIOLOGICAL DIFFERENCES by SEX with EXERCISE

2. w VO2max differences . Parameters to consider w body composition w testosterone:development of strength and fat-free mass. w Upper and lower body strength w Does menstrual cycle affects athletic performance and Does athletic performance affects the menstrual cycle? w Eating disorders, amenorrhea, and bone mineral loss. w Differences in their exercise responses to altitude, heat, humidity, and cold.

3. Issues regarding comparing men and women • Women have higher body fat ~10% • Training history differences • Socio-cultural • Hormonal fluctuations (women) and menstrual state

4. Biological versus Social Differences Performance differences between men and women likely result from biological differences as well as social and cultural restrictions placed on females during their development and the fact that, historically, fewer women have competed in athletic events than men.

5. Body Size and Composition w Major differences between boys and girls do not occur until puberty w Puberty in girls—estrogen causes pelvis broadening, breast development, fat deposition in hips and thighs, increased bone growth, and faster closure of growth plates w Puberty in boys—testosterone causes increased bone formation and muscle mass w After puberty, girls’ average relative body fat is about 10% greater than boys w Men not only have a greater muscle mass, but they carry a higher percentage of their muscle mass in the upper body compared to women

6. SEX DIFFERENCES IN FAT-FREE MASS

7. Effects of Estrogen on Fat Storage 1. Estrogen increases activity of lipoprotein lipase (LPL—produced by fat cells), particularly in the hips and thighs. 2. LPL is bound to walls of capillaries. 3. Chylomicrons—major transporters of triglycerides—pass by in the blood. 4. LPL removes FFA from triglycerides in chylomicrons and they are taken up by fat cells where most of the fat is stored. 5. There is a decrease in lypolytic activity in the sites of fat storage in the hip and thigh areas making it difficult to lose fat in these areas.

8. Relative body fat % Age group (years) Women Men 15-19 20-24 13-16 20-29 22-25 15-20 30-39 24-30 18-26 40-49 27-33 23-29 50-59 30-36 26-33 60-69 30-36 29-33 Relative Body Fat Values for Average, Untrained Women and Men of Various Ages

9. Strength Differences—Women and Men w Innate qualities of muscle and motor control are similar w For the same amount of muscle, strength is similar w Muscle fiber cross-sectional areas are smaller and muscle mass is less in women w More muscle mass is proportionately distributed below the waist in women w Upper-body strength expressed relative to body weight or fat-free mass is less in women w Type I fibers are largest in women whereas IIA fibers are largest in men

11. MEN’S vs WOMEN’S STRENGTH

12. ST FIBER DISTRIBUTION

13. MEN’S vs WOMEN’S STRENGTH

14. . w Same HRmax but lower Qmax because of lower SVmax – w Less potential for increasing a-vO2 diff because of the lower arterial O2 content (lower Hb concentration) Cardiovascular Responses in Women w Higher heart rate response at rest and for same absolute levels of submaximal exercise (about the same Q as men) w Lower SV at rest and at all exercise intensities due to smaller heart size and smaller blood volume w Are woman more suited for ultraendurance exercise?

15. . SUBMAXIMAL HR, SV, AND Q Same absolute poweroutput (50 W) Same relative poweroutput (60% VO2max) .

16. Respiratory Responses in Women w Differences in response from men are mostly due to smaller body size w Higher respiratory rate at given ventilatory rate w Smaller tidal volume at given ventilatory rate w Smaller ventilatory volume during maximal exercise due to smaller lungs

17. . w Average VO2max after puberty is 70% to 75% of the average man’s VO2max—much closer before puberty . – More sex specific body fat – Lower hemoglobin levels and lower total blood volume . – Smaller heart size, thus lower Qmax . w VO2 at same absolute rate of work is similar to a man's w Relative lactate threshold values are similar (i.e., % of VO2max) . Metabolic Responses in Women

18. . w Estrogen enhances glucose uptake during exercise . w Progesterone is a metabolically inflexible state whereas estrogen enhances both glucose and fat oxidation (glycogen sparing) . Metabolic Responses in Women w Progesterone impairs glucose uptake and may block estrogens effects (gestational diabetes)

20. . RANGE OF VO2MAX VALUES Pronghorn antelope: 272 ml/kg/min 77 ml/kg/min: Female Russian x-country skier * 94 ml/kg/min: Male Norwegian x-country skier * p. 579

21. http://www.aei-ideas.org/2013/10/comet-camille-paglia-comes-to-au-and-talks-gender/http://www.aei-ideas.org/2013/10/comet-camille-paglia-comes-to-au-and-talks-gender/

22. . VO2max: Elite Distance Runners and Untrained Subjects

23. Ultraendurance • Metabolic substrate selection • Muscle oxidative stress • Muscle damage • Thermoregulation

24. Fat Metabolism • Women higher fat, higher gluteal/femoral fat (Android, Gynoid fat patterns) • Larger gluteal adipocytes (higher lipolytic rates) • Catechol mediated leg fatty acid release lower in women • Fat oxidation at rest is lower in females • Post-prandial fat deposition higher in viscera in men, sub-Q in women • But, proportion of fat oxidized during exercise higher in women

25. Fat Metabolism • β1, β2, β3 adrenoreceptors stimulate lipolysis • α2 adrenoreceptors inhibit lipolysis • Women have higher α2 in gluteal • Rate of appearance of glycerol higher in women during submax exercise- why? • Lower RER, higher fat oxidation, lower glucose uptake by muscle, lower glycogen use in women • Higher PFK/3-HaCoA DH in muscle of men indicating greater proportion of carb use. • Higher Trigs in muscle of women

27. Protein metabolism • Leucine oxidation may differ both at rest and during exercise • Little difference in overall protein synthesis • Ovarian hormones may inhibit protein synthesis (18% higher leucine oxidation in luteal but progesterone is high?) • Estrogen inhibits PS in vitro • Must control fitness level, fat free mass, age, dietary intake, menstrual cycle, birth control meds • Methods may not be sensitive enough

28. Training and Body Composition in Women w Decreases in fat mass and increases in fat-free mass (FFM), though women generally gain less FFM than men. w Losses in body mass are more related to energy expenditure than to the participant's gender. w Density of weight-bearing bones increases equally in both sexes. w Endurance training strengthens connective tissue in both sexes.

29. Strength Training Adaptations in Women w Women's magnitude of strength gained from resistance training (% increase) is similar to men's. w Women generally don't gain as much muscle size as men from resistance training. w Less muscle mass development may be because of lower testosterone levels.

30. World Olympic Weight-Lifting Records Totals are for the two Olympic lifts, snatch and clean and jerk. The highest weight classification records are not included.

31. Menstrual Cycle Effects on Performance Some female athletes have reportedly set world records during the flow phase while other women report that their performance is inhibited during this phase of the menstrual cycle. No general pattern has been found concerning the ability of women to achieve their best athletic performances during any specific phase of their menstrual cycle.

32. MENSTRUAL CYCLE PHASES

33. Menstrual Effects • Metabolism • luteal increase in glycogen and change in glucose kinetics • Higher protein oxidation in luteal (18%) • Thermogenesis (luteal +0.5 C)

34. Cause or Effect? Menarche (the first menses) tends to come later in highly trained elite athletes in sports or activities such as gymnastics and ballet than in other girls. Does intense training to achieve the level of elite athlete delay menarche, or does a later menarche provide an advantage that contributes to the success of the elite athlete?

35. Amenorrhea—absence of menstruation w Primary—absence of first menses in women 18 and older w Secondary—absence of menstruation sometime after first menses, for at least three consecutive cycles Normal and Abnormal Menstrual Function Menarche—the first menses (can be delayed) Eumenorrhea—normal menstrual function Oligomenorrhea—abnormally infrequent or scant menstruation

36. Menstrual Dysfunction—Amenorrhea w May occur in 2% to 12% of women in general population w May occur in up to 40% of female athletes, depending on the sport and the level of competition w Risk increases with increased duration or intensity of training w Amenorrhea does not necessarily prevent pregnancy, even though some athletes believe amenorrhea is a method of birth control

37. Possible Causes of Menstrual Dysfunction w Prior history of menstrual dysfunction w Acute stress (anxiety, depression, etc.) w High training volume or intensity w Low body weight or body fat; fat converts pre-estrogen steroids into estrogen, so low body fat might affect estrogen levels w Hormonal alterations; e.g., training reduces LH and FSH secretion wProbably the most important factor: inadequate nutrition (energy deficit) and disordered eating; thus training can contribute to the energy deficit; Study: 8 of 13 amenorrheic runners had eating disorders, compared with 0 of 19 eumenorrheic runners

38. Eating Disorders Eating disorders are more serious than “disordered eating” (abnormal eating patterns), but both are causes for concern. The prevalence for both are higher for female athletes than male, especially in appearance, endurance, or weight-classification sports.

39. Anorexia Nervosa w Refusal to maintain more than the minimal normal weight based on age and height w Distorted body image w Intense fear of fatness or gaining weight w Amenorrhea

40. Bulimia Nervosa w Recurrent episodes of binge eating; >2/week for 3 months w A feeling of lack of control during these binges • Purging behavior—self-induced vomiting, laxative use, and/or diuretic use • Non-purging type: fasting or excessive exercise

41. Anorexia Athletica w Not yet clinically recognized as an eating disorder w Intense fear of gaining weight or fat though underweight w A weight loss of at least 5% accomplished by energy deficit w Use of bingeing, self-induced vomiting, laxatives, or diuretics

42. Female Athlete Triad w Disordered eating w Secondary amenorrhea w Bone mineral disorders

43. Factors Contributing to Osteoporosis w Bone mineral loss with aging (especially in women) w Estrogen deficiency w Inadequate calcium intake before early 30s w Inadequate physical activity w Amenorrhea w Anorexia nervosa

44. HEALTHY AND OSTEOPOROTIC BONE

45. BONE MINERAL CONTENT

46. Environment and Performance w Women have lower sweat rates due to lower sweat production, but this does not appear to inhibit their ability to tolerate heat. w Women have more insulating subcutaneous fat than men and, thus, a slight advantage over men during cold exposure, but not in high temperatures. w Women’s smaller muscle mass limits their ability to generate as much body heat as men through shivering. w Women and men have a similar response during exercise at altitude.