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SIMSAM EARLY LIFE

SIMSAM EARLY LIFE. Interdisciplinary research on early life exposure and health. Coordinator : Anna Rignell-Hydbom Co- coordinator Jonas Björk . Division of Occupational and Environmental Medicine, Faculty of Medicine

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SIMSAM EARLY LIFE

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  1. SIMSAM EARLY LIFE Interdisciplinary research on earlylife exposure and health Coordinator: Anna Rignell-Hydbom Co-coordinator Jonas Björk Division ofOccupational and Environmental Medicine, Facultyof Medicine Centre for EconomicDemography, Lund University SchoolofEconomics and Management Departmentof Landscape Architecture, Planning and Management, Swedish University of Agricultural Sciences

  2. SIMSAM Lund • Morethan 100 publicationsbased on registry, survey and biobank data co-authored by SIMSAM Lund participants. • In association to the programme 13 PhD students havedefendedtheirthesis. • Fourteen new PhD students havestartedtheireducationwithin SIMSAM Lund • Post-docshavebeenrecruited • Severalcourses, seminars and workshops • National and international collaborations

  3. SIMSAM Lund – example of articles Associations between gestational complications; gestational diabetes and preeclampsia and air pollution. Malmqvist E, Jakobsson K, Tinnerberg H, Rignell-Hydbom A, Rylander L. Environ Health Perspect. 2013;121:488-493 Background A number of studies have shown associations between maternal air pollution exposure and adverse birth outcomes. However; limited information exist for exposure to air pollution and pregnancy complications 81,110 women (singleton births) 1999-2005 were linked to individually assessed nitrogen oxides and traffic intensity. 1 599 cases of gestational diabetes, 2 370 cases of preeclampsia

  4. Emission and meteorological National Road database data

  5. Results

  6. Maternal smoking duringpregnancy and daughters’risk ofgestational diabetes and obesity Mattsson K, Källén K, Longnecker MP, Rignell-Hydbom A, Rylander L. Diabetologia2013;56:1689-95. • Background • A study from Norway (the MoBacohort) showed • significant associations • However: • Relativelyhighfractionof non-participants • Smoking data collectedretrospectively

  7. Study design Inclusion criteria: Women born 1982 or later who have had at least one child of their own. Complete data on relevant variables (smoking, BMI, birth weight etc) Total of 54 012 women for the final analyses.

  8. Gestational diabetes Obesitas (BMI>30 kg/m2)

  9. Cognitivereserve and dementia – Dekhtyar, S., Wang, H-X., Scott, K., Goodman, A., Koupil, I., Herlitz, A. • Dementia is a debilitating process characterized by the loss of memory and cognitive function in old age • Variations exist in the extent of neuropathology required for dementia diagnoses • To explain the disjunction between the extent of brain damage and its clinical manifestation – RESERVE was suggested • Brain reserve: anatomical features of brain structure help tolerate more dementia • Cognitive reserve: innate intelligence and stimulating life experiences make brain networks more efficient • Cognitive reserve is measured by education or occupational complexity • Educational and occupational attainment have social and cognitive prerequisites • Early cognitive ability could be a better instrument for cognitive reserve • A life-course model of cognitive reserve in dementia is yet to be tested

  10. SIMSAM Lund – Courses and seminars • New courses on advanced topics • Family-based designs(Paul Lichtenstein, Johan Hallqvist, Brian d’Onofrio) • Developmental psychology in a life course perspective (EliaPsuoni, IlonaKuopil) • Bias in observational studies – what can go wrong in Epidemiology? (Jonas Björk) • Collaboration with research schools at the FAS-centreMetaLund and CED at Lund University • Open seminars on methodological issues regularly • In collaboration with EpiHealth and FoU-centrum Skåne

  11. SIMSAM Lund – Open seminars • Registry-based randomized trials • Propensity scores • Introduction to DAGs • Analysis of cross-sectional data • Rasch analysis • Bayesian methods • Qualitative methods • Individual vs. population risk • Multiple imputation • Validation of the Cox model • Age-Period-Cohort modeling • ... Extensive and highly accessed collection of presentations available on-line

  12. Centre for Economic Demography Lund EpiHealth Lund Uppsala Network for PhD-students at SIMSAM Lund SIMSAM network MetaLund LU & LTH • Phd student conferences • Courses • Interdisciplinary projects

  13. SIMSAM Lund – Cohort inventory • Joint initiative with EpiHealth and FoU-centrum Skåne • Close cooperation with SND

  14. SIMSAM Lund – Cohort inventory (cont.)

  15. SIMSAM Lund – additional infrastructure initiatives warranted • Still too hard for researchers outside the “register-based research clusters” to use registry data • Ethics and legislation • Study design • Data access • Data management • Security issues • ...

  16. Knowledge transfer Courses Seminars Workshops Virtual and physical meeting place Consulting and data management facilities SIMSAM Lund Arena for new collaborations Common tools, routines and technical platforms Centre for interdisciplinary research based on registries and biobanks

  17. Tack Anna !! för det fantastiska arbete du gjort för oss dessa år

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