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High Intensity Focused Ultrasound (HIFU) guided by MRI.

High Intensity Focused Ultrasound (HIFU) guided by MRI. Christakis Damianou Frederick Institute of Technology, MEDSONIC LTD November 9, 2006 HIFU Basics. Diagnostic ultrasound intensities: < 1 W/cm 2 HIFU intensities: 500-10000 W/cm 2 . Friction with tissue causes heating.

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High Intensity Focused Ultrasound (HIFU) guided by MRI.

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  1. High Intensity Focused Ultrasound (HIFU) guided by MRI. Christakis Damianou Frederick Institute of Technology, MEDSONIC LTD November 9, 2006

  2. HIFU Basics. • Diagnostic ultrasound intensities: < 1 W/cm2 • HIFU intensities: 500-10000 W/cm2. • Friction with tissue causes heating. • Temperature produced is in the range of 60-100 oC. • Tumors cells are destroyed due to excessive heating. • Spherically focused ultrasound produces localized heating.

  3. MRI/HIFU System Damianou C. et al., Journal of Ultrasound in Medicine and Biology Vol. 30 (3), pp. 397-404, 2004

  4. Video of lesion development in kidney and muscle. • Pulse duration= 10 s

  5. MR compatible transducer. MR compatible transducer Non-MR compatible transducer

  6. MRI monitoring of Ultrasound Hynynen K., Damianou C. “Utrasound surgery", Ultrasound Med. Biol., 1992;19 (1): 91-97.

  7. Video clip of treatment planning strategy.

  8. T2-W FSE: effect of TE. TE=32 ms TE=64 ms C. Damianou et al. Journal of Ultrasound in Medicine & Biology 2004:30 (3):397-404.

  9. Effect of TR on T1-Weighted FSE. TR=300 ms TR=400 ms TR=500 ms TR=700 ms

  10. T1W FSPGR: effect of TR. 2000 W/cm2 for 5 s TR=100 ms TR=50 ms (4x4 lesions) 1 lesion created using cavitation. TR=150 ms TR=300 ms

  11. MRI Monitoring of HIFU in liver. T2-FSE T1-weighted FSE Proton Density Photo

  12. MRI Monitoring of HIFU in liver. MRI(Proton density) Photograph Pathology

  13. Cavitation detection. T1W FSE T2W FSE FSPGR

  14. Cavitation detection. T1W FSE T2W FSE T1W FSPGR

  15. T2W FSE-Comparison of thermal vs. cavitation. 1000 W/cm2 (30 s) 3500 W/cm2 (30 s)

  16. Temperature elevation-thermal mode. Each MRI image is acquired in 5 s (FSPGR). 1000 W/cm2 for 5 s

  17. In vivo results (T2W FSE). 1000 W/cm2 2000 W/cm2 3500 W/cm2

  18. 2-D focal detection using low –intensity ultrasound

  19. Complete coverage Incomplete coverage C. Damianou, Journal of Ultrasound in Medicine and Biology 2004; 30 (9):1209-1215.

  20. Brain tumor strategy. Astrocytoma

  21. SONOMRI by MEDSONIC LTD

  22. MR compatible robot. PCT/CY2006/000001, 19/1/2006

  23. Acoustical coupling

  24. Brain ablation under MRI guidance. T1 FSE T2 FSE Work done by: K. Ioannides FLAIR

  25. Brain ablation. FLAIR T1-FSE C. Damianou, K. Ioannides, J of Ultrasound in Medicine and Biology, in press.

  26. Brain ablation. T1 FSE TR=300 ms TR=500 ms

  27. Brain ablation. FLAIR

  28. Temperature maps using MRI.

  29. Acknowledgments • K. Ioannides (M.D.), M. Komodormos (Ph.D.), Y. Chapelon (Ph.D.), N. Milonas (M.Sc.) Work supported by • ULTRASOUND I, (Res. Prom. Found.) • SONOTHERM (Res. Prom. Found.) • ULTRASOUND II (Res. Prom. Found.) • TROY (FP6) • N2L (FP6) • CDTU (Medical Research foundation of France) • MARiUS (FP6) • SONOMRI (Ministry of industry of Cyprus)

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