Fall Conference 2004

1. University Innovation and Economic Development--Two Case Studies--David McGeeExecutive Director for Technology Business DevelopmentInterim Director, Technology Transfer Fall Conference 2004

2. New Organizational Structure • Establishment of Technology and Industry Alliances (TIA)---July 1, 2004 • De-centralization of Technology Transfer from OTT

3. TIA • Alan Bennett- Assoc. Vice Chancellor • UC Davis CONNECT –Nora Moore-Jimenez • Industry Research Alliances– Mona Ellerbrock • Business Development & Technology Transfer – David McGee

4. TIA Mission • Support effective research collaborations with industry • Ensure translation of University discoveries to private sector for public benefit • Effectively manage University’s IP assets

5. How do we do this? • Foster entrepreneurialism by faculty • Determine commercial potential of inventions • Market the opportunity to potential partners • Establish relationships with financial/investment firms

6. Commercialization opportunities • Nanotechnology • Biotechnology/life sciences • Agriculture • Engineering • Software • Biomedical instrumentation • Nuclear

7. Example Projects for Business Development • Spinouts- Arete, Immunotox, Glycometrix, Tele-interpreting medicine, IR software, 3-D imaging, aeronautical design • Licenses– cattle feed, platelet biostabilization, detection of nucleic acids in animal feed,EMT robotics • LLNL—laser peening (LLNL/MNRC), proton beam, endoscopic device

8. Example Projects continued • UCDMC Translational Grant Program • McClellan Technology Incubator (MTI) • Aging Aircraft Consortium

9. Case Study No. 1: Rumen-protected lipids (Rosenberg and DePeters) • Problem: Increased consumption of ruminant-derived foods linked to rise in cardiovascular and other diseases • due in part to high percentage of saturated lipid content in meat, milk and diary products • Previous attempts to reduce or change unsaturated lipids in ruminants unsuccessful

10. Case Study No. 1: Rumen-protected lipids (Rosenberg and DePeters) • Genetic modification has public resistance • Animal nutrition must be maintained • Direct feeding problematic because of chemistry of rumen

11. Case Study No. 1: Rumen-protected lipids (Rosenberg and DePeters) • Goals: • Deliver unmodified, unsaturated lipids into intestine • Have uptake of unsaturated lipids into circulatory system • Replace saturated lipids with unsaturated lipids • Must have • No adverse effect on animals • No adverse effect on productivity • Safe and no regulatory hurdles

12. Case Study No. 1: Rumen-protected lipids (Rosenberg and DePeters) • Solution: • Provide unsaturated lipid supplements with protective gel delivery system as a feed supplement • This allows unmodified, unsaturated lipids into circulatory system • Observed up to 800% increase in proportion of unsaturated to saturated fatty acids in milk within three days

13. Case Study No. 1: Rumen-protected lipids (Rosenberg and DePeters) • Products—“high-value” commodities: • Animal feed supplement of naturally cross-linked matrix of GRAS components • Can be used to deliver other nutrients and pharmaceuticals • Milk, dairy products and meat

14. Case Study No. 1: Rumen-protected lipids (Rosenberg and DePeters) • Customers: • Animal feed suppliers • Dairy brokers • Fully integrated dairy companies • Dairy product specialty companies • End users

15. Case Study No. 1: Rumen-protected lipids (Rosenberg and DePeters) • Project status: • Currently supplying test samples to prospective customers • Developing term sheet for large multi-national fully integrated firm • Ongoing discussions with a number of other companies • Exploring new applications

16. Case Study No. 2: Aging Aircraft • Problem: • Aircraft are getting older resulting in increasing catastrophic failures and high maintenance costs • Difficult and expensive to detect and repair hidden problems (e.g., cracks, moisture and corrosion) • Current methods are either surface-limited or requires disassembling of aircraft • Aircraft and aircraft parts are being retired based on aging charts, not on actual condition

17. Case Study No. 2: Aging Aircraft • Goals: • Examine aircraft using nondestructive testing (NDT) • Repair aircraft using conventional and advanced methodologies • Reduce downtime and maintenance costs • Develop new aeronautical designs based on test data

18. Case Study No. 2: Aging Aircraft • Solution: • Apply NDT technologies--neutrons, positron annihilation, laser ultrasonics and x-rays of intact aircraft • Apply advanced 3-D imaging technology (New company from UCD) • Apply new aeronautical designs (New company from UCD) • Contract with existing aircraft maintenance companies

19. Case Study No. 2: Aging Aircraft • A unique opportunity: • UC Davis has a one-of-a-kind nuclear reactor designed for delivering neutrons to aircraft • UC Davis has identified strong potential commercial partner for positron source; willing to locate facility at McClellan Park • McClellan Park has existing robotic-controlled x-ray facility

20. Case Study No. 2: Aging Aircraft • A unique opportunity: • McClellan Park has existing laser ultrasonics facility • McClellan Park has unlimited hanger space for additional facilities as required • McClellan Park has existing conventional aircraft maintenance company on site

21. Case Study No. 2: Aging Aircraft Imaging Repair Detection Manage- ment Customers Design Education

22. Case Study No. 2: Aging Aircraft • Project status: • UC Davis has identified laser peening firms for advanced repair • UC Davis has identified aeronautical design faculty who have expertise in aging aircraft and who want to start up a design firm • UC Davis has identified 3-D imaging faculty who want to start up an imaging company

23. Case Study No. 2: Aging Aircraft • Project status: • Business plan is being developed with commercial positron technology partner • Management team being assembled

24. Case Study No. 2: Aging Aircraft • Customers: • DOD • NASA • USDF • CDF • Commercial manufacturers • Commercial airlines

25. Contact Information David McGee drmcgee@ucdavis.edu 530-757-3442 & 916-734-3255