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MK-1775

Boc Sciences offers cas 955365-80-7 MK-1775 in bulk,please inquire us to get a quote for 955365-80-7 MK-1775.<br>https://www.bocsci.com/mk-1775-cas-955365-80-7-item-157422.html<br>

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MK-1775

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  1. MK-1775 - CAS 955365-80-7 Catalog number: B0084-157422 Category: Inhibitor Please be kindly noted products are not for therapeutic use. We do not sell to patients. Molecular Formula C27H32N8O2 Molecular Weight 500.607 COA Inquire Targets Wee1 Description MK-1775, also known as AZD-1775, is a WEE1 inhibitor and a small-molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin- dependent kinase 1 (CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. Unlike normal cells, most p53-deficient or mutated human cancers lack the G1 checkpoint as p53 is the key regulator of the G1 checkpoint and these cells rely on the G2 checkpoint for DNA repair to damaged cells. Annulment of the G2 checkpoint may therefore make p53-deficient tumor cells more vulnerable to antineoplastic agents and enhance their cytotoxic effect. Ordering Information Order Now Bulk Inquiry Publication citing BOC Sciences Products 1.Depressed perivascular sensory innervation of mouse mesenteric arteries with advanced age

  2. 2.Treatment of 17α-ethinylestradiol, 4-nonylphenol, and carbamazepine in wastewater using an aerobic granular sludge sequencing batch reactor 3.LC-MS based metabolite fingerprinting and profiling of a traditional Chinese medicine YANG XIN® formulation 4.Development and validation of rapid and simultaneous method for determination of 12 hair-growth compounds in adulterated products by UHPLC– MS/MS 5.Phosphonated polyimides: enhancement of proton conductivity at high temperatures and low humidity 6.Determination of 26 anti-diabetic compounds in dietary supplements using a validated UPLC method >> More Specification Properties Reference Reading    Purity >98% Appearance Yellow Solid Powder Synonyms MK-1775; MK1775; MK 1775; AZD1775; AZD-1775; AZD 1775; adavosertib. 1-[6-(2- hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2- enylpyrazolo[3,4-d]pyrimidin-3-one MSDS Inquire https://www.bocsci.com/mk-1775-cas-955365-80-7-item-157422.html

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