Regulation of Feed Intake in Transition Cows

1. Regulation of Feed Intake in Transition Cows Barry Bradford Associate Professor Kansas State University 135 Call Hall, Manhattan, KS 66506 bbradfor@ksu.edu 1-785-532-7974

2. Typical Transition Cow Goals • Avoid transition disorders • Promote a steady rise in feed intake and milk production to meet peak lactation goals • Set the stage for reproductive success • Key to all of these: Minimize time and degree of negative energy balance

3. Promoting energy intake Energy intake = dry matter intake X energy density • Management • Carbohydrate profile • Bioactive nutrients • Nutrient profile

4. Hepatic Oxidation Theory (HOT) • Liver is “hard-wired” to brain feeding centers via vagus nerve • Great variation in pattern of oxidation of fuels over the short-term • Feed intake is affected by pattern of oxidation • Goal: maximize the amount of glucose produced per unit of ATP generated in the liver over time

5. What are “hot” and “cold” diets? • Hot = highly fermentable • Highly digestible forage sources • Relatively high concentrate levels • Some substitution of forage with nonforage fiber sources (byproducts) • Cold = less fermentable • Higher forage concentrations • Some poorly digestible forage (i.e. straw) • Resistant starch and/or nonforage fiber replaces some processed starch

6. Peak lactation cow Satiety Maximal milk yield HOT Diet

7. Peak lactation cow Satiety COLD Diet Milk yield constrainedby nutrient supply

8. What about the transition cow?

9. Fat mobilization Triglycerides (TG) Fatty Acids (NEFA) Adipocytes Oxidized or Stored as TG Oxidized Milk Fat TG Liver Muscle Mammary

10. lipolysis, lipogenesis plasma insulin NEFA hepatic oxidation plasma glucose Depressed feed intake during the transition period feed intake

11. Can limiting NEFA release preventing DMI depression? • Fed 24 g/d rumen-protected niacin • Close-up ration: • 35% NFC, 42% NDF, 1.55 Mcal NEL / kg DM • Fresh cow ration: • 40% NFC, 32% NDF, 1.69 Mcal NEL / kg DM • Treatments from 21 days before calving to 21 DIM Morey et al., 2011

12. Encapsulated niacin decreased plasma NEFA Day relative to calving Morey et al., 2011

13. Niacin did not increase DMI Day relative to calving Morey et al., 2011

14. Niacin has NEFA-independent effects Titgemeyer et al., 2011

15. lipolysis, lipogenesis plasma insulin NEFA hepatic oxidation plasma glucose Depressed feed intake during the transition period - Propionate feed intake + Propionate

16. Propionate has dual effects in early lactation • Experimental infusion of propionate for 72 hours in early lactation decreased feed intake by 10% compared to acetate infusion • This response was the most dramatic in cows with high blood NEFA concentrations Stocks and Allen, 2010, 2011

17. How much starch in early lactation? • Diets were based on corn silage (35%) and alfalfa silage (11.5%) and included 4% wheat straw • Corn meal, soy hulls, and wheat midds were varied Nelson et al., 2011

18. High starch diet limited DMI Trt: P = 0.06 Time: P < 0.001 Trt x Time: P = 0.09 LL > HH: P ≤ 0.10 Courtesy of H. M. Dann n = 78 (total) Nelson et al., 2011

19. …and milk yield Trt: P = 0.04 Time: P < 0.001 Trt x Time: P = 0.75 MH > HH: P ≤ 0.05 Courtesy of H. M. Dann n = 78 (total) Nelson et al., 2011

20. Moderate starch delayed NEFA normalization Courtesy of H. M. Dann n = 78 (total) Nelson et al., 2011

21. What about sugar? • Sucrose was used to replace cracked corn grain at 4.7% of diet dry matter • Diets were approximately 34% NDF, 34% NFC • 20.5 vs. 18.5% starch • 4.5 vs. 8.7% water-soluble sugars • Fed for first 28 days in milk Penner and Oba, 2009

22. Dietary sucrose increased DMI, ECM Over the first28 days in milk P = 0.09 P = 0.04 n = 52 (total) Penner and Oba, 2009

23. Dietary sucrose in transition diets • Sucrose did not alter energy balance • Sucrose decreased plasma glucose and increased NEFA and BHBA concentrations • Increased ruminal pH (6.06 vs. 6.21, P = 0.08) • Increased total-tract OM digestibility, not NDF • Increased ruminal NDF digestibility and passage? Penner and Oba, 2009

24. Fat in peak lactation? • Cows were fed a common diet for first 21 DIM, then randomly assigned to 1 of 4 diets: • 60:40 forage:concentrate • 2.9% fatty acids • 5.0% fatty acids (prilled hydrogenated fatty acids) • 40:60 forage:concentrate • 3.4% fatty acids • 5.5% fatty acids (prilled hydrogenated fatty acids) Weiss and Pinos-Rodriguez, 2009

25. Fat in peak lactation? n = 72 (total) Weiss and Pinos-Rodriguez, 2009

26. Fat in peak lactation? n = 72 (total) Weiss and Pinos-Rodriguez, 2009

27. Fat in peak lactation? n = 72 (total) Weiss and Pinos-Rodriguez, 2009

28. Fat in peak lactation? n = 72 (total) Weiss and Pinos-Rodriguez, 2009

29. Transition diet recommendations • Goals: Decrease NEFA, maintain rumen fill • Feed fiber with long ruminal retention time • Target moderate starch fermentability to supply adequate propionate without rapid production in a meal • Consider using a sugar source (4-5% of DM)

30. When to change to the peak diet? • Ideally, change to peak-lactation diet when plasma NEFA and ketones decrease and intake is steadily increasing • Practically, cows with steadily rising feed intake and milk yield may be ready to shift diets as early as 7 days in milk, or as late as 21 days in milk

31. Peak lactation • Dry matter intake is limited by gut fill in most cows • Additional energy in the form of starch or fat should not depress DMI (within reason) • Additional energy can increase BOTH milk production and BCS

32. Conclusions • Attempts to prevent negative energy balance in early lactation haven’t worked! • More energy in = more milk, in most cases • There is hope for improved feed intake, which generally improves transition performance

33. Thank you!