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Fundamentals of Genetics Chapter 9. What makes you who you are, your genes or your environment????? BOTH!!!. Thalidomide (1957-1961) -causes phocomelia (flipperlike arms/legs) Can you think of other examples?. Environmental Influences. Mendel.
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Fundamentals of GeneticsChapter 9 • What makes you who you are, your genes or your environment????? • BOTH!!! .
Thalidomide (1957-1961) -causes phocomelia (flipperlike arms/legs) Can you think of other examples? Environmental Influences
Mendel • Gregor Mendel (Born 1822) Monk worked with pea plants
Stamens: actually anthers on the end of the stamen produces pollen which contains sperm cells inside (male structure) Stigmas: actually ovary in pistil produces egg cells (female structure)
What Mendel did with Pea Plants • Removed stamens from flowers so self-pollination could not occur. • Worked with only one visible trait at a time. • Kept detailed record of crosses and results.
Terminology for Results • Parent generation P1 • Offspring of parent generation =F1 (first filial generation) • Offspring of offspring=F2 (second filial generation)
Page 176 in book What do you notice about the observed ratio?
Mendel's Experiment - P1=tall x short - F1=all tall - F2= 3/4 tall and 1/4 short -Mendel studied many different traits Mendel’s Results
This led Mendel to these conclusions: • Mendel's first hypothesis: inherited characteristics are controlled by factors (genes) which occur in pairs. ex. Tt or TT or tt
2. Mendel's second hypothesis (Principle of dominance and recessiveness): one gene of a pair may mask (hide) the other, or prevent it from having an effect. • Ex. Tt= TALL
Mendel's third hypothesis: (Law of Segregation): a pair of genes are separated during the formation of the gametes (sperm and egg).
Law of Independent Assortment: the separation of gene pairs occurs entirely independent of the separation of all other gene pairs in an organism.
Molecular Genetics Supports Mendel • Gene- segments of DNA on a chromosome *genes occur in pairs • Genes have different forms called alleles *we use letters to represent alleles ex. T or t
Genetic Problem • In eyecolor, BROWN is dominant to blue. Pres. George Bush is heterozygous for BROWN eyes. Laura Bush has blue eyes. Complete a Punnett square showing the possible eyecolors of their twin daughters.
STEP #1 Write Genotypes of Parents • Males 1st, female 2nd • If Dominant use all Capital Letters • If Recessive use lower Case 1. GT: Bb x bb
STEP #2- Write Phenotypes of Parents • Write Male 1st, female second • 1.GT: Bb x bb • 2. PT: BROWN x blue
STEP #3 - Punnett Square • Draw Tic Tac Toe Board • Males on vertical side • Females on horizontal • Complete Punnett Square 1. GT: Bb x bb • PT: BROWN x blue 3.
Step #4- Write Genotypic Ratio or Genotypic Fraction • Compares the chances of getting different genotypes in the offspring. 1. GT: Bb x bb • PT: BROWN x blue 4. GF: 2/4 Bb, 2/4 bb
STEP #5- Write Phenotypic ratio or Phenotypic Fraction • Compare the chances of different phenotypes in the offspring. • 1. GT: Bb x bb • 2. PT: BROWN x blue 3. • 4. GF: 2/4 Bb, 2/4 bb • 5. PF: 2/4 BROWN, 2/4 blue
In eyecolor BROWN eyes are dominant to blue eyes. Chuck is homozygous for BROWN, his wife Lyn has blue eyes. What color eyes can their kids have? • 1. BB x bb • 2. BROWN x blue • 3. • 4. GF: 4/4 Bb • 5. PF: 4/4 BROWN
Special Punnett Squares 1. Test Cross • A punnet sq. done to determine if parent is homo or heterozygous. • Involves crossing the unknown parent genotype with a homozygous recessive genotype • BB or Bb x bb • If all offspring are dominant then parent was homozygous; if some offspring are recessive then parent was heterozygous.
Test Cross Question • A purple flowered pea plant is crossed with a white flowered pea plant. 5 of the 6 pea plants resulting from the cross are purple but one is white. • What is the genotype of the purple pea plant?
Occurs when the heterozygous is an intermediate between the homozygous dominant and recessive. Incomplete Dominance
2. Codominance • Occurs when both alleles are fully expressed in the offspring. • Neither allele is dominant, and no blending occurs.
Blood Type • Ex of codominance • Blood types M, N, MN are determined by 2 alleles LM, LN
Polygenic Traits • Most human characteristics are polygenic • Polygenic traits are controlled by several genes • Ex skin color, height, hair color • AABBCCDD- dark skin • AABBccdd or AaBbCcDd or…-med skin • Aabbccdd –fair skin