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Chap 9/11 : Fundamentals of Genetics. Mendel -- Gregor Mendel – “Father of Genetics” – worked with pea plants. Discovered inheritance (passing of traits from parents to offspring). A. Terminology. 1. Pure or Strain – trait that’s always passed to offspring.
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Chap 9/11 : Fundamentalsof Genetics Mendel -- Gregor Mendel – “Father of Genetics” – worked with pea plants. Discovered inheritance (passing of traits from parents to offspring)
A. Terminology • 1. Pure or Strain – trait that’s always passed to offspring. • 2. P1 generation – parents • 3. F1 generation – 1st filial generation – offspring of P1 • 4. F2 generation – offspring of F1
B. 3 Principles of inheritance • 1. Principle of Dominance andRecessiveness – says that traits that mask other traits are called dominant traits (R) and those that don’t are recessive traits (r). • 2. Principle of Segregation – each trait is expressed by 2 factors – one from each parent • Ex. RR x rr = Rr • (mom) (dad) (offspring)
3. Principle of Independent Assortment – says traits are independent from each other.Ex. Eye color and hair color are independent of each other. C. Chromosomes and Genes gene – piece of DNA calling for a specific trait – like eye color allele – that form of a gene. Ex. Blue, brown, or green gene chromosome
II. Genetic Crosses • A.1. Genotype – genetic makeup of an organism. Expressed with letters. (Rr) • 2. Phenotype – physical appearance of an organism (ex. Blue eyes) • 3. Homozygous – when both alleles of a pair are the same. (RR or rr) • 4. Heterozygous – when the alleles of a pair are not the same. (Rr)
Ex. B- black b - blonde Bb (dad) x bb (mom) Geneotype: Bb bb Phenotype: black blonde heterozygous homo. Rec. Homozygous dominant – BB Homozygous recessive – bb 5. Multiple alleles – when 3 or more alleles control 1 trait. ex. Blood type : A, B, O
6. Probability – the likelihood of something occurring. #of 1 kind of event / # of events • Ex. 50 tosses of coin • 18 heads, 32 tails. What is the probability of tossing a head ? • 18/50 = 36 % B. Monohybrid crosses – cross between 1 trait
--- Punnett Square – tool used to predict the probability from genetic crosses. • Types of Monohybrid Crosses • In rats brown fur is dominant over white fur. If a homozygous dominant and homozygous recessive parent produced offspring, what would be their genotypes and phenotypes ? B- brown b-white BB x bb G: 100% Bb b b P : 100% Brown B Bb Bb B Bb Bb
2. If two of the offspring from #1 were mated what would be the outcome ? B- brown b- white Bb x Bb G : 1 BB B b 2 Bb B BB Bb 1 bb b Bb bb P : 3 brown 1 white
3. In pea seeds round is dominant over wrinkled. If a heterozygous seed is mated with a wrinkled one what percentage would end up wrinkled ? R- round r – wrinkled Rr x rr r r R Rr Rr r rr rr 50 % would be wrinkled
4. Test Cross – used to determine the genotype of a dominant phenotype. • In mice red eyes are recessive to blue. A mouse has blue eyes and you want to know if red eyes “run in the family line”, how can you determine this ? --- Perform a test cross – cross the mouse with a homozygous recessive (one with red eyes). B? X bb = ?. If any offspring have red eyes you would know the allele in question was for red eyes.
4. Codominance – when one or more alleles is considered dominant. The result produces a blend of the alleles. • Ex. Flower petals exhibit codominance.If a red flower was crossed with a white flower describe the genotype and phenotype of the offspring. R – red R’ – white RR x R’R’ R’ R’ R RR’ RR’ R RR’ RR’ G: all RR’ P : all pink
C. Dihybrid Crosses – cross between individuals that involves 2 different traits. • In Peas, round seeds are dominant to wrinkled and yellow is dominant to green. What would be the genotype and phenotye of the offspring of a homo.rec. and homo.dom. parents ? R – round G- yellow r – wrinkled g – green RRGG x rrgg 1 2 3 4 1 2 3 4
RG(1+3) RG(1+4) RG(2+3) RG(2+4) (1+3) rg RrGg RrGg RrGg RrGg (1+4) rg RrGg (2+3) rg (2+4) rg G : all RrGg P : all round and yellow
Ex. If two offspring from above were to be mated what would be the phenotypes of the offspring ? • RrGg x RrGg • RG(1+3) Rg(1+4) rG(2+3) rg(2+4) • RG RRGG RRGg RrGG RrGg • Rg RRGg RRgg RrGg Rrgg • rG RrGG RrGg rrGG rrGg • rg RrGg Rrgg rrGg rrgg • Phenotypes : • 9 round and yellow (R_G_) • 3 round and green (R_gg) • 3 wrinkled and yellow (rrG_) • 1 wrinkled and green (rrgg)