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Tablet Coating

Tablet Coating. Why coat tablets? Types of coatings sugar coating film coating press coating (compression coating). Sugar Coating. stages involved sealing of tablet core subcoating smoothing colouring polishing printing. Film Coating.

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Tablet Coating

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  1. Tablet Coating • Why coat tablets? • Types of coatings • sugar coating • film coating • press coating (compression coating)

  2. Sugar Coating • stages involved • sealing of tablet core • subcoating • smoothing • colouring • polishing • printing

  3. Film Coating • involves spraying a solution of polymer + pigments + plasticizers onto a rotated, mixed tablet bed • forms a thin, uniform film on tablet surface • materials • polymers • solvents • plasticizers • colorants

  4. Film Formation latex particles dispersed in aqueous phase formation of thin film with water evaporation through film continuous film

  5. Coating Process • coating pans

  6. Coating Process • fluid beds

  7. Important Processing Parameters • inlet and bed temperatures • relative humidity • atomization air pressure • liquid spray rate • droplet size • drying time

  8. Coating Problems • picking/chipping • roughness • sticking • film cracking/peeling

  9. Normal Coating

  10. Enteric-coated • coating resists dissolution or disruption in stomach but not in intestines • used for drugs that are unstable, irritating to stomach

  11. Enteric Coating

  12. Press Coating • use of compression to form coat around a pre-formed core • used mainly to separate chemically incompatible materials • also dual release patterns possible

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