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A. NKG2D. IL-2 + IL-12 +/- Dorsomorphin ( M). 100. 80. 60. % Max. 0. 1. 40. 20. 2. 5. 0. 10 0. 10 1. 10 2. 10 3. 10 4. 100. DMSO C ontrol. 80. 60. % Max. 40. 20. 0. 10 0. 10 1. 10 2. 10 3. 10 4. B. IL-2 + IL-12. + DMSO. ( M). + Dorsomorphin.
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A NKG2D IL-2 + IL-12 +/- Dorsomorphin (M) 100 80 60 % Max 0 1 40 20 2 5 0 100 101 102 103 104 100 DMSO Control 80 60 % Max 40 20 0 100 101 102 103 104 B IL-2 + IL-12 + DMSO (M) + Dorsomorphin IFN- (pg/ml) * C % Specificlysis * * 5 1.25 2.5 0.62 0.31 Effector:Target Ratio Suppl. Figure 3