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Integrated Biosurveillance Bioterrorism Preparedness Advanced Briefing for Industry Dec, 2004

. Anthrax Cases in DC. Flu Flu Flu. . . . Biosurveillance Challenges. Outbreak Detection ? Preparation, Response, RecoveryOutbreak Attribution: Natural vs Accidental vs Intentional. Data courtesy of Medstar

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Integrated Biosurveillance Bioterrorism Preparedness Advanced Briefing for Industry Dec, 2004

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    1. Integrated Biosurveillance & Bioterrorism Preparedness Advanced Briefing for Industry Dec, 2004

    4. Biosurveillance Projects ALADDIN – Automated Link Analysis for Data-Mining of Distributed Information Phase II SBIR - Charles River Analytics Bayesian Belief Network, clinical & non-clinical data Health Information Data Mining for Early Identification of Bioterrorism Phase II SBIR – Dynamics Technology AADP - Automated Anomaly Detection Processor, clinical & non-clinical data ESSENCE - Electronic Surveillance System for the Early Notification of Community-based Epidemics Worldwide daily syndromic surveillance of military outpatient clinic visits Evaluating incorporation of microbiology lab orders

    5. Biosurveillance Projects

    6. Biosurveillance Projects – West Nile Virus

    8. Biosurveillance Projects - SARS Retrospective evaluation of data sources 10/02: enviro-clim – lowest temperature in 62 yrs 11/02: media – school, factory closings reported 2/03: socio-economic – stores, parks deserted 2/03: transportation – subways, buses deserted 2/03: telecom – increased cell phone text messaging 2/03: internet – PROMED “unusual pneumonia” WHO global alert issued 15 March 03 8 countries already involved, including US Ultimately >8400 people infected in 30 countries Case fatality rate up to 15%

    9. Biosurveillance Projects - Argus Objectives Policy & legal review Prospective prototype Response issues Disease models SARS/Avian influenza Rift Valley Fever Geographic areas Asia/Pacific East Africa Data sources News Media Transportation Telecommunication Enviroclimatic MOH Websites

    10. Established at Drexel University in Philadelphia, 2000 Rural partner in western PA - St Francis Univ Web-based training a major focus www.cimerc.org Chem-bio self assessment survey Incident scenario guidebook Educational and informational resources Argentina effort – Spanish translations, evaluations Other potential collaboration

    11. CIMERC Self Assessment Survey

    12. CIMERC Problem Simulation Exercises 20 Scenarios… Conventional Disasters Terrorism - Conventional Explosives Chemical Agent Release Infectious Disease Outbreak Contagious Disease Outbreak Nuclear/Radiological Incident

    13. Future Directions Biosurveillance Incorporation of other data sources – animal, plant, biosensor Integration with response community National efforts & guidelines – BioSense, CDC, NBIS/NBIC, Military Bioterrorism Preparedness Targeted, modular advanced distributed learning Novel, simulation-based response training

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