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Atomic Structure of Tubulin.

Atomic Structure of Tubulin. (Ribbon and Space Filling Models). Molecular Structure of a Nucleoside Triphosphate (ATP or GTP). TEM of Self Assembled MTs and MTs Assembled on a Centrosome “template”. Microtubules and Motors: MT polymer ratchets and motor proteins. F ~1-50pN. F ~ 1-10pN.

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Atomic Structure of Tubulin.

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  1. Atomic Structure of Tubulin. (Ribbon and Space Filling Models)

  2. Molecular Structure of a Nucleoside Triphosphate (ATP or GTP)

  3. TEM of Self Assembled MTs and MTs Assembled on a Centrosome “template”

  4. Microtubules and Motors: MT polymer ratchets and motor proteins. F ~1-50pN F ~ 1-10pN

  5. Filament Assembly and Force Production.

  6. Microtubule Polymer Dynamics Dynamic Instability. (Mitchison and Kirschner, 1984). Flux. (Margolis and Wilson, 1978; Mitchison, 1989).

  7. GTP hydrolysis and Dynamic Instability at Steady State.

  8. Metaphase Anaphase A Anaphase B Microtubule Dynamics in Anaphase A

  9. Mechanism of Chromosome Movement. Kinetochore motility - Pacman versus poleward flux.

  10. Metaphase Anaphase A Anaphase B MT dynamics in Anaphase B

  11. Anaphase B Spindle Elongation 1. A motor-dependent sliding filament mechanism generates force to push the poles apart. 2. Poleward flux acts as a regulatory switch.

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