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1. Sickle Cell Disease Matt Lawson
2. Heredity: Sickle Cell Disease
3. Picture
4. Signs and Symptoms The most common signs or symptoms are related to:
Anemia
Pain when sickle-shaped red blood cells block the flow of blood to an organ
The general signs or symptoms of anemia are:
Fatigue (feeling very tired)
Paleness
Jaundice (yellowing of the skin and eyes)
Shortness of breath
5. Medical sickle cell anemia may and can cause death
no cure for disease yet
Two separate types
Sickle cell hemoglobin (HbSS)
Hemoglobin C with sickling (HbSC)
treatments: penicillin prophylaxis, vaccination against pneumococcus bacteria and folic acid supplementation.
Medicans to help: antibiotics, pain management, intravenous fluids, blood transfusion, and surgery backed by psychosocial support
Blood transfusions help sickle cell patients by reducing recurrent pain crises, risk of stroke, and other complications
Most patients live to twenty to fifty years of age
6. Personal recurrent aplastic and hemolytic crises resulting in anemia and gallstones
multisystem disease (kidney, liver, lung)
narcotic abuse
splenic sequestration syndrome
acute chest syndrome
erectile dysfunction (as a result of priapism)
blindness/visual impairment
neurologic symptoms and stroke
joint destruction
gallstones
infection, including pneumonia, cholecystitis (gallbladder), osteomyelitis (bone), and urinary tract infection
parvovirus B19 infection resulting in aplastic crisis
tissue death of the kidney
loss of function of the spleen
leg ulcers
death
7. Possible Cures Although no “golden cure” there is possible options such as:
Droxia
Hydroxyurea
Although there are some complications…
red blood cells contain iron so there is no natural way for body to eliminate it
8. Sickle Cell References