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Controls of the Cell Cycle

Controls of the Cell Cycle. External Chemical Physical. Internal. Ex. At M phase checkpoint. Chemical signals essential nutrient growth factors. Density-dependent inhibition crowded cells stop dividing. Cells must be attached to a substratum

brigitte-lennon
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Controls of the Cell Cycle

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  1. Controls of the Cell Cycle

  2. External • Chemical • Physical • Internal

  3. Ex. At M phase checkpoint

  4. Chemical signals • essential nutrient • growth factors

  5. Density-dependent inhibition • crowded cells stop dividing

  6. Cells must be attached to a substratum • ex. inside of a culture jar or ECMof a tissue

  7. Don’t respond to body’s control mechanisms • Divide excessively • Don’t exhibit density-dependent inhibition

  8. “Immortal” HeLa cells

  9. Diverse • Gene alteration

  10. Worst 5 Foods www.copperwiki.org/index.

  11. How Cancer cells spread

  12. Transformation (normal cell to cancer cell)‏ • Tumor (mass of abnormal cells w/in normal tissue)‏ • Benign tumor • Malignant tumor / cancer • Metastasis How Cancer Cells Spread

  13. 1. High-energy radiation • For localized tumor • Destroys DNA in cancer cells

  14. 2.Chemotherapy • For metastatic tumors • For actively dividing cells • Side effects

  15. To summarize…

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