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Inhibition of TGF-ß release from SHED Cells in Fibrodysplasia Ossificans Progressiva

SHED Cells. 24 Hours of TNF- α. Normal Media Before TNF- α. Normal Media After TNF- α. FOP Media Before TNF- α. FOP Media After TNF- α. Insult causing Inflammation. Pure TGF- ß. Anti-TGF- ß1. 12.5KD. Macrophage Activation. Lymphocyte Activation. TNF- α. IFN- γ. SHED Cells.

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Inhibition of TGF-ß release from SHED Cells in Fibrodysplasia Ossificans Progressiva

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  1. SHED Cells 24 Hours of TNF-α Normal Media Before TNF-α Normal Media After TNF-α FOP Media Before TNF-α FOP Media After TNF-α Insult causing Inflammation Pure TGF-ß Anti-TGF-ß1 12.5KD Macrophage Activation Lymphocyte Activation TNF-α IFN-γ SHED Cells 6 Hours of TNFα + IFNγ Activated Mesenchymal Stem Cells FOP: TGF-ß FOP Lysate Normal Lysate Normal: TGF-ß Anti-TGFß1 44kD Less immunosuppression Immense Inflammation Bone Formation Immunosuppression Resolves Inflammation Inhibition of TGF-ß release from SHED Cells in Fibrodysplasia Ossificans Progressiva Brendan Everett, Robert Pignolo, Frederick Kaplan Robert Wood Johnson Medical School, UMDNJ and Perelman School of Medicine, University of Pennsylvania

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