1 / 14

Chlorhexidine & the Blood Donor

Chlorhexidine & the Blood Donor. Cynthia T Crosby TJ Smith December 12, 2002. OVERVIEW. Antiseptic Agents - QUICK REVIEW NDA submission Overview of DATA CHG in vascular access Blood Donor Facilities & the National Blood Service (UK) Q & A. Alcohol. Broad spectrum

bruno-munoz
Download Presentation

Chlorhexidine & the Blood Donor

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Chlorhexidine & the Blood Donor Cynthia T Crosby TJ Smith December 12, 2002

  2. OVERVIEW • Antiseptic Agents - QUICK REVIEW • NDA submission • Overview of DATA • CHG in vascular access • Blood Donor Facilities & the National Blood Service (UK) • Q & A

  3. Alcohol • Broad spectrum • Denatures cell proteins and dissolves cell lipids • Concentration • Ideal at 70% to 90% • Quick dry time • Rapidity of action: immediate • Lack of residual property • Irritation • Flammability

  4. Iodophors • Iodine complexed with an inert polymer • Why? To Reduced skin irritation and sensitization • Effects are neutralized by blood • 2 to 3 minute dry time • Sensitivity and toxicity issue, especially infants

  5. Tincture of Iodine • Combination product • 1% or 2% free available iodine • Quick to dry • Irritation? • Mechanism: • Free iodine penetrates cell and replaces components • Effects are neutralized by organic material (blood)

  6. Chlorhexidine • Primary advantages: • Residual activity • Affinity to bind to the skin • Superior efficacy • Less skin irritation • Broad-spectrum • Activity in the presence of organic matter #1

  7. IDEAL Antiseptic PROPERTIES: • Broad spectrum • Rapid bactericidal activity • Persistent • Active in BLOOD/Organic • Non-irritating • Minimal absorption

  8. Combination Products • Chlorhexidine and alcohol (ChloraPrep) • PVP-I and alcohol • Tincture of Iodine * Convenience * Compliance

  9. NDA submission & DATA • ChloraPrep is a combination product • 2% chlorhexidine gluconate • 70% isopropyl alcohol • Clinical DATA • 2% CHG/70% IPA combination demonstrated a greater log reduction than • 10% PVP-I • 70% isopropyl alcohol • 2% aqueous CHG

  10. What Prep to Use? • Povidone-Iodine (2 step procedure) • Standard prep for donor prep (AABB) • Tincture of Iodine and CHG are superior to Povidone-Iodine • Tincture of Iodine (2 step procedure) • Proposed for “Standards of Blood Banking and Transfusion” • 2% Chlorhexidine-based (1-step procedure) • Equivalent to Tincture of Iodine • Proposed as an Alternative Prep • COMPLIANCE TO PROTOCOL

  11. New CDC Guidelines • Prevention of Intravascular Catheter-Related Infections • Education and dedicated resources • IV Teams • Phlebotomy Teams • Maximal Barriers • 2% chlorhexidine-based antiseptic

  12. Preventative measures are the highest quality in medical treatment and the most cost efficient!

More Related