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U F

Basic Model 1: One strain, one drug, no drug resistance, no health workers, no special treatment area. U D. U C. U F. infection. a. γ. C. F. D. b. drug δ 2. δ. α. 1- α. drug. μ. μ 1. μ.

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U F

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  1. Basic Model 1: One strain, one drug, no drug resistance, no health workers, no special treatment area. UD UC UF infection a γ C F D b drug δ2 δ α 1-α drug μ μ1 μ

  2. Basic Model 2: One strain, one drug, no drug resistance, no health workers, special treatment area. UD UD’ UC UF ε infection a D’ C F D γ b drug,δ2 α δ 1-α drug μ2 μ μ1 μ

  3. infection HF γ HC drug,δ3 ε1 ε1 HD Basic Model 3: One strain, one drug, no drug resistance, health workers, no special treatment area. UD UC UF γ a drug,δ2 C F D b infection drug, δ μ α 1-α μ1 μ

  4. infection HF γ HC drug δ3 ε1 ε1 HD Basic Model 4: One strain, one drug, no drug resistance, health workers, special treatment area. UD UD’ UC UF γ ε a drug, δ2 D’ C F D b infection α δ μ 1-α drug μ2 μ1 μ

  5. infection HF γ HC drug,δ3 ε1 ε1 HD Basic Model 5: Two patient risk groups UC UD UF UD’ γ ε a drug, δ2 D’ C F D b infection drug δ μ 1-α μ1 μ2 α μ UD’r UFr UDr UCr γ ε a drug, δr2 D’r Cr Fr Dr b infection drug δ μr μr2 α 1-α μr1

  6. δ α1 μ α2 drug 1-α5 drug δ2 infection α3 α5 γ aR CR DR bR μR μ Basic Model 6: Two strains, one drug, drug resistance, no health workers, no special treatment area. UD UC UF infection a Sensitive strain C F D γ b μ μ1 drug treatment Super- infection α4 Resistant strain

  7. Basic Model 7: Three strains, two drugs, drug resistance, no health workers, no special treatment area. μ1 UD1 UC1 μ a1 C1 Strain 1 D1 b1 infection super- infection drug δ1 Drug 1 γ1 drug δ1 UC2 a2 UD2 C2 infection Strain 2 D2 F γ2 b2 μ2 drug δ2 super- infection μ drug δ2 infection Drug 2 γR aR CR Resistant strain DR bR μR μ

  8. Strain 1 Drug 1 Strain 2 Drug 2 Resistant strain Basic Model 8: Three strains, two drugs, drug resistance, no health workers, but with special treatment area. μ1 UD1 UC1 μ a1 ε1 C1 D1 D’1 b1 infection drug δ1 γ1 drug δ1 super- infection UD2 UC2 ε2 C2 a2 infection D’2 D2 F γ2 b2 drug δ2 μ2 μ super- infection drug δ2 infection γR εR CR aR D’R DR bR μR μ

  9. Strain 1 Drug 1 Strain 2 Drug 2 Resistant strain Basic Model 9: Three strains, two drugs, drug resistance, health workers μ1 UD1 UC1 μ a1 ε1 C1 D1 D’1 b1 infection drug δ1 γ1 drug δ1 UD2 UC2 a2 ε2 C2 infection D’2 D2 F γ2 b2 drug δ2 μ2 μ super-infection drug δ2 infection Cx,Dx,D’x γR εR aR CR D’R DR bR μ μR infection HF γ HC1,HC2,HCR drug δH1 or δH2 ε ε HD

  10. HCWs in Model 9 Infection-1 from patients C1, D1,D’1 Infection-2 from patients C2, D2,D’2 ε1 HC1 HD1 Infection-R from patients CR, DR,D’R γ1 infection-1 ε1 drug δH1 ε2 ε2 infection-2 HF HF HC2 HD2 γ2 drug δH2 εR infection-R γR HCW HT1 & HC1 can move Fs to C1 εR HCW HT2 & HC2 can move Fs to C2 HCR HDR HCW HTR & HCR can move Fs to CR

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