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I’m a good Bacteria!

Probiotics and the brain: Can they make you smarter?. I’m a good Bacteria!. Objectives. Ice breaker Who am I ? Introduce the topic Brief methods Data analysis Over to you! Questions at the end . Who is listening?. Who am I?. Sum!. Why am I here?. Introduction to the topic .

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I’m a good Bacteria!

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  1. Probiotics and the brain: Can they make you smarter? I’m a good Bacteria!

  2. Objectives • Ice breaker • Who am I ? • Introduce the topic • Brief methods • Data analysis • Over to you! • Questions at the end

  3. Who is listening?

  4. Who am I? Sum!

  5. Why am I here?

  6. Introduction to the topic

  7. Background

  8. Aims To assess whether probiotic supplements can alter the behaviour of rats when given an object novelty task

  9. Methods Experimental set up 5 mins or 1 hour delay 2 1 1 1 Sample phase Test phase

  10. A brief video showing the test phase • http://people.sju.edu/~mander06/NORVideos.htm

  11. Data at a 5 minute delay

  12. Data at a 1 hour delay

  13. Hypothesis (What do I expect?)

  14. The task The data presented represents one of the experiments I did which looked at testing a rat’s ability to tell a novel object from a familiar one. The more time a rat spends with a novel object, the better it is! With this in mind, I want you to plot my data (all on the same graph) and show me whether the control group or the probiotic group is better at this task. Think also about how you present the data (i.e. do you need to plot every point or is there a better way of showing the trends?) I also want you to tell me what the mean values for the two different groups are and what the effect of putting a longer delay is. Please also calculate the standard deviation and standard error of the mean for each group.

  15. Over to you…what did you find?

  16. Some YouTube clips • http://www.youtube.com/watch?v=ubNF9QNEQLA • http://www.youtube.com/watch?v=URLRdcnU6Hk

  17. References • Good, M. A., Barnes, P., Staal, V., McGregor, A. and Honey, R. C. (2007). Context- but not familiarity-dependent forms of object recognition are impaired following excitotoxic hippocampal lesions in rats. Behavioral Neuroscience121:218-223. • Good, M. A. and Hale, G. (2007). The "Swedish" Mutation of the Amyloid Precursor Protein (APPswe) Dissociates Components of Object-Location Memory in Aged Tg2576 Mice. Behavioral Neuroscience121:1180-1191. • Hohmann, C. F., Walker, E. M., Boylan, C. B. and Blue, M. E. (2007). Neonatal serotonin depletion alters behavioural responses to spatial change and novelty. Brain Research1139:163-177. • Barker, G. R. I., Bird, F., Alexander, V. and Warburton, E. C. (2007). Recognition memory for objects, place, and temporal order: A disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex. Journal of Neuroscience27:2948-2957. • Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J., and Dinan, T. G. (2008). The probiotic Bifidobacteriainfantis: An assessment of potential antidepressant properties in the rat. Journal of Psychiatric Research43: 164-174.

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