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The role of mTOR in memory CD8 + T-cell differentiation

The role of mTOR in memory CD8 + T-cell differentiation. Koichi Araki, Ben Youngblood, Rafi Ahmed Immunological Reviews 2010 Vol. 235: 234-243. mTOR ( mammalian Target of Rapamycin ). Mondino A et al. Semin Immunol 2007;19:162-172. mTOR ( mammalian Target of Rapamycin ).

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The role of mTOR in memory CD8 + T-cell differentiation

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  1. The role of mTOR in memory CD8+ T-cell differentiation Koichi Araki, Ben Youngblood, Rafi Ahmed Immunological Reviews 2010 Vol. 235: 234-243

  2. mTOR ( mammalian Target of Rapamycin ) Mondino A et al. Semin Immunol 2007;19:162-172

  3. mTOR ( mammalian Target of Rapamycin ) Thomson AW et al. Nat Rev Immunol2009;9:324-337

  4. Rapamycin Araki et al. Immunological Rewiews 2010;235:234-243

  5. The mTOR signaling cascade Mamane Y et al. Oncogene 2006;25:6416-6422

  6. The mTOR signaling cascade FKBP12 Araki et al. Immunological Rewiews 2010;235:234-243

  7. The mTOR signaling cascade Wullschleger S et al. Cell 2006;124:471-484

  8. Memory CD8+ T-cell differentiation Araki et al. Immunological Rewiews 2010;235:234-243

  9. Memory CD8+ T-cell differentiation Araki et al. Immunological Rewiews 2010;235:234-243

  10. mTOR and Memory CD8+ T-cell differentiation Araki et al. Immunological Rewiews 2010;235:234-243

  11. mTOR and Memory CD8+ T-cell differentiation Araki et al. Immunological Rewiews 2010;235:234-243

  12. mTOR and Memory CD8+ T-cell differentiation Araki et al. Immunological Rewiews 2010;235:234-243

  13. Immunosuppressive effects of rapamycin Without Costimuation Mondino A et al. Semin Immunol 2007;19:162-172

  14. Immunosuppressive effects of rapamycin

  15. Immunosuppressive effects of rapamycin • Diffrentiation into Treg cells • Changing T-cell trafficking • Suppressing diffrentiation and maturation of DCs

  16. Immunostimulatory effects of rapamycin

  17. Immunostimulatory effects of rapamycin • Increased IL-12 of mDCs treated with rapamycin • Enhanced antigen presentation by rapamycin-induced • autophagy of DCs

  18. Viral infection versus tissue transplant • Viral infection has a potent ability to activate the innate • immune system • Rapamycin might inhibit the immune response only • when combined with other therapies, or rapamycin’s • immunostimulatory effects may be masked by other • drugs

  19. Targeting mTOR to enhance vaccine immunogenicity • Using rapamycin as an adjuvant • - It can be taken orally - Rapamycin does not need to be combined with the vaccine

  20. Summary • Rapamycin has immunostimulatory effects - Memory CD8+ T-cell differentiation - Increasing IL-12 of mDCs - Enhanced antigen presentation by autophagy of DCs • Rapamycin has immunosuppressive effects - Diffrentiation into Treg cells - Changing T-cell trafficking - Suppressing diffrentiation and maturation of DCs • Rapamycin can be used as a vaccine adjuvant, but it is common immunosuppressive drug for organ transplantation. So, rapamycin has to be investigated more.

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