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UW – River Falls Clinical and Biotechnology Applications of Engineered Materials August 8, 2008

UW – River Falls Clinical and Biotechnology Applications of Engineered Materials August 8, 2008. Michael Haider President, Chief Executive Officer BioE, Inc. BioE. Privately held Company established 1993 Focused on umbilical cord blood derived stem cells

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UW – River Falls Clinical and Biotechnology Applications of Engineered Materials August 8, 2008

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  1. UW – River Falls Clinical and Biotechnology Applications of Engineered MaterialsAugust 8, 2008 Michael Haider President, Chief Executive Officer BioE, Inc.

  2. BioE • Privately held Company established 1993 • Focused on umbilical cord blood derived stem cells • Two internally developed stem cell platforms: • PrepaCyte™-Stem Cell isolation • MLPC™ (Multi Lineage Progenitor Stem Cell) derived from umbilical cord blood • Strategic partners, Phillips Plastics (WI) for development of extra cellular matrixes (ECM) for tissue engineering.

  3. Multi-lineage Progenitor Cells (MLPC) Applications in Cellular and Regenerative Medicine Confidential

  4. Development of MLPC for Cartilage Repair Cells are seeded onto ECM constructed from TCP, titania, alumina, hydroxyapatite, PEEK, collagen, cellulose Cells are differentiated into chondrocytes within ECM Expand cells in MLPC morphology Cells are differentiated into chondrocytes in suspension culture Chondrocytes

  5. Development of MLPC for Bone Repair Differentiate to osteoblasts within ECM Cells are seeded into ECM constructed from TCP, titania, alumina, hydroxyapatite, PEEK Expand cells in MLPC morphology Osteoblasts

  6. Development of Bi-functional Tissue Differentiate to chondrocytes in suspension culture Allow attachment of chondrocyte clusters to surface of MLPC-osteoblast impregnated ECM Chondrocytes Expand cells in MLPC morphology Osteoblasts Differentiate to osteoblasts within ECM Seed MLPC into ECM Confidential

  7. BioE Imagine the Possibilities

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