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CH 17 – WBC Morphology

CH 17 – WBC Morphology. Five Types of Leukocytes (WBCs). Eosinophil. Neutrophil. Basophil. Granular Leukocytes. Neutrophil. 60-70% of all WBC’s Anatomy 10-12 µm diameter 2-6 nuclear lobes Fine, pale inconspicuous granules Physiology Respond first to bacteria damage by chemotaxis

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CH 17 – WBC Morphology

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  1. CH 17 – WBC Morphology

  2. Five Types of Leukocytes (WBCs)

  3. Eosinophil Neutrophil Basophil Granular Leukocytes

  4. Neutrophil • 60-70% of all WBC’s • Anatomy • 10-12 µm diameter • 2-6 nuclear lobes • Fine, pale inconspicuous granules • Physiology • Respond first to bacteria damage by chemotaxis • Phagocytosis • After engulfing pathogen releases several chemicals • lysozyme • strong oxidants • defensins

  5. Eosinophil • 2-4% of all WBC’s • Anatomy • 10-12 µm diameter • 2 connected nuclear lobes • red/orange large, uniform granules, do not obscure the nucleus • Physiology • exit capillaries, enter tissue fluid • combat parasites • histamine • phagocytize antigen-antibody complexes

  6. Basophil • 0.5-1% of all WBC’s • Anatomy • 8-10 µm diameter • bilobed or irregular nucleus • round, blue-black granules may obscure the nucleus • Physiology • exit capillaries to enter tissue fluid • mature into mast cells • release heparin, histamine, serotonin – stimulate inflammation • Hypersensitivity (allergic) reactions

  7. Lymphocyte Monocyte Agranular Leukocytes

  8. Lymphocytes • 20-25% of all WBC’s • Anatomy • 7-15µm • nucleus large and dark stained, round or indented • cytoplasm forms a pale blue rim around the nucleus

  9. Monocytes • 3-8% of all WBC’s • Anatomy • 14-19 µm • indented or kidney-shaped nucleus (not round) • cytoplasm foamy • Physiology • slower to arrive but survive longer • enlarge, differentiate into fixed and wandering macrophages • remove microbes, cellular debris, following injury

  10. End WBC Morphology CH 17

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