AI-augmented Drug Discovery

May 23, 2023

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Creative Biolabs provides innovative drug discovery services based on our original AI-augmented technology, especially therapeutic antibodies and small molecules. For more, https://ai.creative-biolabs.com/.

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AI-augmented Drug Discovery

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DRUG DISCOVERY – NEW DRUG DEVELOPMENT PROCESS

DRUG DISCOVERY – NEW DRUG DEVELOPMENT PROCESS. BY. Dr. BASAVARAJ K. NANJWADE. Department of Pharmaceutics K L E UNIVERSITY JN MEDICAL COLLEGE BELGAUM – 590010 E-mail: bknanjwade@yahoo.co.in. DRUG.

1.58k views • 55 slides

Drug discovery and development

Drug discovery and development. Ian Hughes, i.e.hughes@leeds.ac.uk Objectives of next 5 lectures: you will: be aware of why/how new drugs are discovered know the processes involved in drug discovery and development see where pharmacologists/bioscientists may contribute

833 views • 31 slides

Drug Design / drug discovery

Drug Design / drug discovery. Jerome Baudry Assistant Professor BCMB UT/ORNL Center for Molecular Biophysics. 2 previous incarnations: Research faculty at UIUC Research scientist at Transtech Pharma, Inc. . Drug Design / drug discovery. What’s a drug?

994 views • 26 slides

Drug Discovery Process

Dalla malattia al bersaglio biologico. La progettazione di un nuovo farmaco deve derivare da una necessit terapeutica (disease selection)Individuata la malattia, individuare il gene responsabile della disfunzione (gene to function)Individuata la funzione fisiologica compromessa, risalire alla pro

1.23k views • 55 slides

Drug Discovery

Drug Discovery. The use of solid phase combinatorial chemistry and parallel synthesis. Problems with Traditional Synthesis. 1 chemist 1 molecule Can only make one molecule at a time Each synthesis very time consuming Multistep syntheses have loss at each step

942 views • 34 slides

Process of Drug Discovery

Process of Drug Discovery. History …… Plant products pre-date the rise of modern medicine …… Use of opium, licorice, ephedra, marijuana, camellia, alcohol, digitalis, cocoa, quinine etc… …… First discovered was morphine (opium), which was found to be alkaline (1817)

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Drug Discovery and Development

Drug Discovery and Development. How are drugs discovered and developed?. Choose a disease Choose a drug target Identify a “bioassay” bioassay = A test used to determine biological activity. Find a “lead compound”

1.24k views • 69 slides

DRUG DISCOVERY

DRUG DISCOVERY. Random Search e.g., buying paintbrush, mop, hammer, gluestick, nail, etc. etc. for hanging a picture frame on the wall Rational Design e.g., buying a nail for hanging the frame Combinatorial Search

324 views • 10 slides

Modern drug discovery techniques

Modern drug discovery techniques. Drugs were discovered through identifying the active ingredient from traditional remedies or by unexpected discovery.

848 views • 30 slides

Drug Discovery and Development

Drug Discovery and Development. How are drugs discovered and developed?. Basic Steps. Choose a disease Choose a drug target Identify a “bioassay” bioassay = A test used to determine biological activity. Find a “lead compound”

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Drug Discovery and Development

Drug Discovery and Development. Kelompok tutor B4. Adriansah Sudarmin M. Kautsar Natanael P Tri Taufiqurachman T Dhita Dewi A Hidayatul Husna Aisyah Riseta Gracia Natasha Nadhila Kaulika Arlinda De Hafsari Rika Nurlaily Fani Fitria.

399 views • 14 slides

Drug Discovery & Development

Drug Discovery & Development. PHC 323. LEC. 9. II-Improving metabolism :. I-Making drugs more resistant to chemical and enzymatic degradation. 1)- Steric shields Some functional groups are more susceptible to chemical and enzymatic degradation than other.

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Ligand-based drug discovery

Ligand-based drug discovery. No a priori knowledge of the receptor What information can we get from a few active compounds. Drug-likeness: what makes a drug a drug?. Lipinski’s “rule of 5”: most drugs have less than two violation of the following rules: * ≤ 10 hydrogen bond acceptors

943 views • 14 slides