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Neural cell lines have been used as excellent in vitro models for research of neural process, drug discovery, and toxicity screening testing due to their many advantages.<br>https://neuros.creative-biolabs.com/category-neural-cell-lines-42.htm

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neuros-celll-line-product-panel-com

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  1. Neural Cell Lines TEL: 1-631-357-2254 E-mail: info@creative-biolabs.com SUITE 203, 17 Ramsey Road, Shirley, NY 11967, USA neuros.creative-biolabs.com

  2. Cutting Edge Tools for Neuroscience Research In 2005, Creative Biolabs opened its doors offering neuroscience research antibodies with the goal of putting customers first. From day one, our vision has been to provide products you can trust. We stand behind our products—leading us to create our policy of replacing or refunding reagents or cells that do not meet expectations. As our number of loyal and satisfied customers grow, so do our offerings. Our selection of antibodies has expanded, along with other products, including human cells, specialized media, sera, and cell models. We continue to assess the needs of the neuroscience research field and add new resources to our neuroscience range to add to our cutting edge technologies. Currently, Creative Biolabs offers a range of specific tools & reagents to allow you stay at the forefront of your field. Creative Biolabs is your source for neural cells, media and supplements including iPSC-derived cells. Our large range of substrates and matrices including natural extracellular matrices and artificial scaffolds gives you numerous options to develop your in vitro system. We also offer innovative neural tracers and customized technical services that help researchers explore questions about genes, neurons, circuitry structure, function of brain network, mechanism and treatment of diseases. We also have an extensive biorepository with neural tissue from numerous species. We will always offer proven reagents for results you can trust and understand. Cutting Edge Tools for Neuroscience Research

  3. Table of Contents Neural Cell Lines Neural Cell Lines Neural Stem Cells Neural Progenitor Cells Neurons Astrocytes Microglial Cells Oligodendrocytes Schwann Cells Neurological Disease Cell Models Neural Tissues Neural Tissues Neural Cell Culture Media and Supplements Neural Cell Culture Media and Supplements Neural Cell Culture Matrices Neural Cell Culture Matrices Neural Cell Transfection Neural Cell Transfection Neural Cell Cryopreservation Neural Cell Cryopreservation Cutting Edge Tools for Neuroscience Research

  4. Neural Cell Lines Cellular models are highly important tools for numerous applications in neuroscience, for example the study of neurodegeneration, neurogenesis and developmental diseases. There is also a growing sense of the importance of studying the behaviour of neurons, glial cells and neural stem cells within a physiologically relevant context. Creative Biolabs offers a range of cryopreserved human, mouse and rat neural cells and neurological disease models to allow you stay at the forefront of your field. With years of experience in primary neural cell isolation, Creative Biolabs offers ready-to use, high quality primary neural cells for your research. Extensive testing and optimization provides quality and performance of our neural cells with every batch produced. Creative Biolabs' portfolio also includes reliable neural media products (see page 16 ) that are optimized and tested specifically with our neural cells. Creative Biolabs guarantees the performance of its cells when cultured with the recommended medium and following the protocol. Neuron Astrocyte Microglia Neural Progenitor Cell Neural Stem Cell Oligodendrocyte Cutting Edge Tools for Neuroscience Research

  5. Neural Cell Lines Neural stem cells are undifferentiated cells found within the brain. They were first described in the subventricular zone (SVZ) by Sally Temple in 1-8- but were not isolated until 1--2 from adult striatal tissue by Brent Reynolds. Like mesenchymal stem cells, neural stem cells have the capacity to undergo extensive cell divisions in vitro and are multipotent in nature. Human iPSC Human iPSC- -Derived Neural Stem Cells Derived Neural Stem Cells Human iPSC-derived Neural Stem Cells from Healthy Donors Cat. Product Name Starting Material Quantity 1.5 million cells & Neural Plating-XF Medium 1.5 million cells & Neural Plating-XF Medium 1.5 million cells & Neural Plating-XF Medium 1.5 million cells & Neural Plating-XF Medium 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP01 Human iPSC-Derived Neural Stem Cells (Male), Source Cord Blood CD34+ Cells Cord Blood CD34+ Cells Human iPSC-Derived Neural Stem Cells (Male), Source Cord Blood CD34+ Cells, Validated NCL-2101-ZP02 Cord Blood CD34+ Cells NCL-2101-ZP03 Human iPSC-Derived Neural Stem Cells (Female), Source Cord Blood CD34+ Cells Cord Blood CD34+ Cells Human iPSC-Derived Neural Stem Cells (Male), Source Fibroblasts (74 Yr Donor), Validated NCL-2101-ZP04 Fibroblasts (74 Yr Donor) NCL-2101-ZP05 Human iPSC-Derived Neural Stem Cells (Female), Source Fibroblasts (64 Yr Donor) Fibroblasts (64 Yr Donor) Human iPSC-derived Neural Stem Cells from Patient Donors Cat. Product Name Starting Material Quantity 1.5 million cells & Neural Plating-XF Medium 1.5 million cells & Neural Plating-XF Medium 1.5 million cells & Neural Plating-XF Medium 1.5 million cells & Neural Plating-XF Medium 1.5 million cells & Neural Plating-XF Medium 1.5 million cells & Neural Plating-XF Medium 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP06 Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (APOE4 HOM) Fibroblasts (87 Yr Female) NCL-2101-ZP07 Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 L286V) Fibroblasts (38 Yr Female) NCL-2101-ZP08 Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 M146L) Fibroblasts (53 Yr Male) NCL-2101-ZP0- Human iPSC-Derived Neural Stem Cells - Alzheimer's Disease Patient (PSEN1 A246E) Fibroblasts (31 Yr Female) NCL-2101-ZP10 Human iPSC-Derived Neural Stem Cells - Huntington's Disease Patient Fibroblasts (48 Yr Female) NCL-2101-ZP11 Human iPSC-Derived Neural Stem Cells - Epilepsy Patient Fibroblasts (5 Mo Female) NCL-2101-ZP12 Human iPSC-Derived Neural Stem Cells - Trisomy X Patient Fibroblasts (74 Yr Female) CRIGEM™ Genetically Edited Human iPSC-derived Neural Stem Cells Cat. Product Name Starting Material Quantity 1.5 million cells & Neural Plating-XF Medium 1.5 million cells & Neural Plating-XF Medium 1.5 million cells & Neural Plating-XF Medium 1.5 million cells & Neural Plating-XF Medium 1.5 million cells & Neural Plating-XF Medium 1.5 million cells & Neural Plating-XF Medium 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP05 Human iPSC-Derived Neural Stem Cells (Female), Source Fibroblasts (64 Yr Donor) Fibroblasts (64 Yr Donor) NCL-2101-ZP14 CRIGEM™ iPSC-Derived Neural Stem Cells LRRK2 G201-S HOM Fibroblasts (64 Yr Donor) NCL-2101-ZP15 CRIGEM™ iPSC-Derived Neural Stem Cells LRRK2 G201-S HET Fibroblasts (64 Yr Donor) NCL-2101-ZP16 CRIGEM™ iPSC-Derived Neural Stem Cells MAPT R406W HET Fibroblasts (64 Yr Donor) NCL-2101-ZP17 CRIGEM™ iPSC-Derived Neural Stem Cells MAPT V337M HOM Fibroblasts (64 Yr Donor) NCL-2101-ZP18 CRIGEM™ iPSC-Derived Neural Stem Cells MAPT V337M HET Fibroblasts (64 Yr Donor) NCL-2101-ZP1- CRIGEM™ iPSC-Derived Neural Stem Cells MAPT P301L HOM Fibroblasts (64 Yr Donor) 1.5 million cells & Neural Plating-XF Medium NCL-2101-ZP20 CRIGEM™ iPSC-Derived Neural Stem Cells MAPT P301L HET Fibroblasts (64 Yr Donor) Mouse/Rat Neural Stem Cells Mouse/Rat Neural Stem Cells Cat. Product Name Cell Type NCL-2105-P205-AM Mouse Embryo Neural Stem Cells, Immortalized Immortalized Cell NCL-2108P23 Mouse Neural Stem Cells Ne-4C Immortalized Cell NCL-2108P25 Mouse Neural Stem Cells C17.2 Immortalized Cell NCL-2105-C356 Mouse Neural Stem Cells, Adult Primary Cell NCL-2105-F356 Mouse Neural Stem Cells, Fetal Primary Cell NCL-2108-P016 Mouse Cortical Neural Stem Cells Primary Cell NCL-2108-P017 Mouse Spinal Cord Neural Stem Cells Primary Cell NCL-2105-P242-AM Rat Neural Stem Cells (1464R), Immortalized Immortalized Cell NCL-2108-P01- Rat Neural Stem Cells, Adult Primary Cell NCL-2108-F01- Rat Neural Stem Cells, Fetal Primary Cell NCL-2108-C001 Rat Neural Stem Cells Fetal (E14 cortex) Primary Cell Cutting Edge Tools for Neuroscience Research

  6. Neural Progenitor Cells Since the discovery that neural progenitor cells (NPCs) from induced pluripotent stem cells (iPSCs) can proliferate or differentiate into neurons, oligodendrocytes, or astrocytes, NPCs are becoming an attractive in vitro model to study neurological development and neurotoxicity and to model diseases. Creative Biolabs’ NPCs are derived from a collection of well-characterized, integration-free reprogrammed iPSCs. For investigators looking to reduce the time from initial culture to experiment readout, our NPCs can eliminate the 4 to 8 weeks for iPSCs to differentiate into NPCs. Creative Biolabs provides a complete system of NPC solutions for investigating development, degeneration and regeneration, neurogenetics, neural excitability, nervous system disorders, neurotransmitters, and screening therapeutics. • Normal and neurological disease iPSC-derived NPCs • Gene-edited, lineage-specific reporter NPCs • Expansion and differentiation media kits • Validated growth and differentiation protocols Selected Neural Progenitor Cell Lines Selected Neural Progenitor Cell Lines Cat. Product Name Cell Type NCL-2108-P001 Human Neural Progenitor Cells, Fully Validated Primary Cell NCL-21P6-17- Human Neural Progenitor Cell Line, Cortical Derived Primary Cell NCL-2105-P11-HP NeuCell™ Human GABAergic Neural Progenitor Cells (GPC), 1M Primary Cell NCL-2105-P17-HP NeuCell™ Human Motor Neural Progenitor Cells (MPC), 1M Primary Cell NCL-2105-P2--HP NeuCell™ Human Dopaminergic Neural Progenitor Cells (DPC), 1M Primary Cell NCL-2105-P33-HP NeuCell™ Human Glutamatergic Neural Progenitor Cells (GPC), 1M Primary Cell NCL200506ZP Human Oligodendrocyte Progenitor Cells Primary Cell NCL-2105-P187-AM Human Cranial Suture Progenitor Cells (iSuPs), Immortalized Immortalized Cell NCL-2108P147 Human Neuron Progenitor Cells (Neu41), Immortalized Immortalized Cell NCL200501ZP Human Neural Progenitor Cell Line, Cortical Derived, Immortalized Immortalized Cell NCL-21P6-212 Human Neural Progenitor Cell Line, Ventral Mesencephalon Derived, Immortalized Immortalized Cell NCL-2108-P002 NeuCELL™ VM Human Neural Progenitor Cell Line, Immortalized Immortalized Cell NCL-2108-P003 NeuCELL™ CX Human Neural Progenitor Cell Line, Immortalized Immortalized Cell NCL-2105-P211-AM Mouse Neural Progenitor Cells, Immortalized Immortalized Cell NCL-2105-P276-AM Mouse Pituitary Progenitor Cells (αT1-1), Immortalized Immortalized Cell NCL-2105-P247-AM Rat Sympathoadrenal Progenitor Cells (MAH-A3), Immortalized Immortalized Cell NCL-2108-P007 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone A4H1 Disease Model NCL-2108-P008 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone D4 Disease Model NCL-2108-P00- Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone B2 Disease Model NCL-2108-P010 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone 3C1 Disease Model NCL-2108-P011 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone A5 Disease Model NCL-2108-P012 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone E6F4 Disease Model NCL-2108-P013 Alzheimer's 3Dish™ NeuCELL™ VM Human Neural Progenitor Cell Line, Clone H10 Disease Model Cutting Edge Tools for Neuroscience Research

  7. Neurons Neurons (also called neurones or nerve cells) are the fundamental units of the brain and nervous system, the cells responsible for receiving sensory input from the external world, for sending motor commands to our muscles, and for transforming and relaying the electrical signals at every step in between. Creative Biolabs supplies a number of high viability cryopreserved and live primary neurons which are ideal for studying mechanisms of developmental neurobiology, disease progression, neurotoxicology and other areas of neuroscience. Selected Neurons Selected Neurons Human Neurons Cat. Product Name Cell Type NCL-2103-P71 iNeu™ Human iPSC-derived Motor Neurons Primary Cell NCL-2103-P77 iNeu™ Human iPSC-derived Dopaminergic Neurons Primary Cell NCL-2103-P78 iNeu™ Human iPSC-derived Cortical Neurons Primary Cell NCL-2103-P62 iNeu™ Human iPSC-derived Sensory Neurons Primary Cell NCL-21P6-001 iNeu™ Human iPSC-derived Spinal Motor Neurons Primary Cell NCL-21P6-002 iNeu™ Human iPSC-derived Layer V Glutamatergic Neurons Primary Cell NCL-21P6-003 iNeu™ Human iPSC-derived Midbrain Dopaminergic Neurons Primary Cell NCL-21P6-004 iNeu™ Human iPSC-derived Cortical GABAergic Neurons Primary Cell NCL-21P6-005 iNeu™ Human iPSC-derived Cortical Glutamatergic Neurons Primary Cell NCL-21P6-007 iNeu™ Human iPSC-derived Mixed Cortical Neurons Primary Cell NCL-21P6-008 iNeu™ Human iPSC-derived Medium Spiny Neurons Primary Cell NCL-21P6-025 Human Hippocampus-derived Neurons Primary Cell NCL-21P6-172 Human Midbrain-derived Neurons Primary Cell NCL-21P6-027 Human Brain Stem-derived Neurons Primary Cell NCL2110P18- Human Cortical-derived Neurons Primary Cell NCL-2105-P130-IX Human iPSC-derived Motor Neurons (Amyotrophic Lateral Sclerosis Patient, Sporadic) Disease Model NCL-2105-P133-IX Human iPSC-derived Motor Neurons (SOD1 mutant, A4V, HOM) Disease Model NCL-2105-P134-IX Human iPSC-derived Motor Neurons (TDP-43 mutation, M337V, HET) Disease Model NCL-2105-P135-IX Human iPSC-derived Motor Neurons (TDP-43 mutation, Q331K, HET) Disease Model NCL-2105-P136-IX Human iPSC-derived Motor Neurons (TDP-43 mutation, M337V, HOM) Disease Model NCL-2105-P137-IX Human iPSC-derived Motor Neurons (TDP-43 mutation, Q331K, HOM) Disease Model NCL-2105-P138-IX Human iPSC-derived Motor Neurons (TDP43 mutation, N352S, HET) Disease Model Cutting Edge Tools for Neuroscience Research

  8. Neurons Mouse Neurons Cat. Product Name Cell Type NCL-21P6-051 Mouse C57 Brain Hippocampus Neurons Primary Cell NCC20--PZ47 Mouse CD1 Brain Hippocampus Neurons Primary Cell NCC20--PZ48 Mouse C57 Brain Cortex Neurons Primary Cell NCC20--PZ52 Mouse CD1 Brain Cortex Neurons Primary Cell NCC20--PZ53 Mouse C57 Brain Striatum Neurons Primary Cell NCC20--PZ56 Mouse CD1 Brain Striatum Neurons Primary Cell NCL-21P6-044 Mouse CD1 Brain Raphe-derived Neurons Primary Cell NCL-21P6-045 Mouse C57 Brain Raphe-derived Neurons Primary Cell NCL-21P6-052 Mouse CD1 Substantia Nigra-derived Neurons Primary Cell NCL-21P6-053 Mouse C57 Substantia Nigra-derived Neurons Primary Cell NCL-21P6-055 Mouse CD1 Ventral Spinal Cord-derived Neurons Primary Cell NCL-21P6-056 Mouse CD1 Dorsal Spinal Cord-derived Neurons Primary Cell NCL-21P6-057 Mouse C57 Dorsal Spinal Cord-derived Neurons Primary Cell NCL-21P6-058 Mouse CD1 Spinal Cord-derived Neurons Primary Cell NCL-21P6-05- Mouse C57 Spinal Cord-derived Neurons Primary Cell NCL-2108P2- Mouse Hippocampal Neuron Cells (HT-22), Immortalized Immortalized Cell NCL-2105-P20--AM Mouse Hypothalamic Neurons - SV40T, Immortalized Immortalized Cell NCL-2105-P212-AM Mouse Neuronal Cells (M4b), Immortalized Immortalized Cell NCL-2105-P213-AM Mouse Trisomy 16 Neuronal Cells (MTh), Immortalized Immortalized Cell Rat Neurons Cat. Product Name Cell Type NCL-21P6-08- Rat Substantia Nigra-derived Neurons Primary Cell NCL-21P6-0-1 Rat Ventral Spinal Cord-derived Neurons Primary Cell NCL-21P6-0-2 Rat Dorsal Spinal Cord-derived Neurons Primary Cell NCL-21P6-0-3 Rat Spinal Cord-derived Neurons Primary Cell NCL-2103-P15 Rat Cortical Neurons (RCoN) Primary Cell NCL-2103-P16 Rat Dorsal Root Ganglion Neurons (DRG) Primary Cell NCL-2103-P17 Rat Hindbrain Neurons (RHbN) Primary Cell NCL-2103-P18 Rat Hippocampal Neurons (RHiN) Primary Cell NCL-2103-P21 Rat Midbrain Neurons Primary Cell NCC20--PZ15 Rat Dorsal Root Ganglion (DRG) Neurons, Neonatal Primary Cell NCC20--PZ20 Rat Embryonic Dorsal Root Ganglion (eDRG) Neurons Primary Cell NCC20--PZ5- Rat Brain Striatum Neurons Primary Cell NCC20--PZ60 Rat Cerebellar Granular Neurons Primary Cell Live Ready-To-use Neurons Cat. Product Name Cell Type N100200-AM E18 Hippocampal Neurons 1 M cells/vial N200200-AM E18 Cortical Neurons 1 M cells/vial N300200-AM P8 Cerebellar Neurons 4 Pairs N400200-AM E18 Hypothalamus Neurons 1 Pair N500200-AM E18 Striatal Neurons 1 Pair N600200-AM E18 Spinal Cord Neurons 1 Cord N700200-AM E18 Midbrain Cells 1 Midbrain Cutting Edge Tools for Neuroscience Research

  9. Astrocytes Astrocytes are highly heterogeneous neuroglial cells with distinct functional and morphological characteristics in different parts of the brain. They are responsible for maintaining a number of complex processes needed for a healthy central nervous system (CNS). Creative Biolabs' astrocyte precursor and mature cells are derived from neural stem cells differentiated from fully characterized, normal karyotype human induced pluripotent stem cells (hiPSCs), using proprietary induction protocols that produce high purity astrocytes, and using xeno-free and integration-free derivation and culturing. >-0% GFAP+ cells; <1% Tuj1+ cells with typical astrocyte morphology • Characterized using immunocytochemistry and whole genome profiling • Suitable for co-culturing with neurons for complex tissue modeling • Limited proliferative potential and long-term viability • Selected Astrocytes Selected Astrocytes Human Astrocytes Cat. Product Name Cell Type NCL-21P6-00- Human iPSC-derived Cortical Astrocytes Primary Cell NCL-21P6-010 Human iPSC-derived Spinal Astrocytes Primary Cell NCL-21P6-032 Human Cerebral Cortex-derived Astrocytes Primary Cell NCL-21P6-033 Human Cerebellum-derived Astrocytes Primary Cell NCL-21P6-034 Human Spinal Cord-derived Astrocytes Primary Cell NCL-21P6-035 Human Hippocampus-derived Astrocytes Primary Cell NCL-21P6-036 Human Brain Stem-derived Astrocytes Primary Cell NCL-21P6-037 Human Midbrain-derived Astrocytes Primary Cell NCL-21P6-038 Human Retinal-derived Astrocytes Primary Cell NCL2110P1-5 Human Mesencephalic-derived Astrocytes Primary Cell NCL-21P6-14- Human Brain Astrocytes-GFP Primary Cell NCL-21P6-150 Human Brain Astrocyte-RFP Primary Cell NCL-2103-P01 Human Astrocytes (HA), Cryopreserved, Fetal Primary Cell NCL-2103-P03 Human Astrocytes (HA), Cryopreserved, Adult Primary Cell NCL-2105-P180-AM Human Astrocytes, Fetal - hTERT, Immortalized Immortalized Cell NCL-2105-P182-AM Human Astrocytes, Fetal - SV40, Immortalized Immortalized Cell NCL-2105-P336-AM Human Brain Astrocytes-GFP, Immortalized Immortalized Cell NCL-2105-P340-AM Human Brain Astrocyte-RFP, Immortalized Immortalized Cell NCL2110P065 Human Astrocyte Cell Line SVG P12, Immortalized Immortalized Cell Mouse Astrocytes Cat. Product Name Cell Type NCL-21P6-064 Mouse Astrocytes from CD1 Primary Cell NCL-21P6-065 Mouse Astrocytes from C57BL/6 Primary Cell NCL-21P6-066 Mouse Brain Cerebellar Cortex-derived Astrocytes-from CD1 Primary Cell NCL-21P6-067 Mouse Brain Cerebellar Cortex-derived Astrocytes-from C57BL/6 Primary Cell NCL-21P6-071 Mouse Spinal Cord-derived Astrocytes-from CD1 Primary Cell NCL-21P6-072 Mouse Spinal Cord-derived Astrocytes-from C57BL/6 Primary Cell NCL-21P6-073 Mouse Brain Stem-derived Astrocytes-from CD1 Primary Cell NCL-2105-P154-IX Mouse Midbrain-derived Astrocytes Primary Cell NCL-2105-P155-IX Mouse Brain Hippocampus-derived Astrocytes Primary Cell NCL-2105-P156-IX Neonatal Mouse Spinal Cord-derived Astrocytes Primary Cell NCL-2105-P153-IX Neonatal Mouse Brain Cerebellar Cortex-derived Astrocytes Primary Cell NCL-2105-P1---AM Mouse Astrocytes - SV40T (IMA2.1), Immortalized Immortalized Cell Rat Astrocytes Cat. Product Name Cell Type NCL-21P6-076 Rat Cerebellum-derived Astrocytes Primary Cell NCL-21P6-077 Rat Hippocampus-derived Astrocytes Primary Cell NCL-21P6-078 Adult Rat Brain-derived Astrocytes Primary Cell NCL-21P6-07- Rat Retinal-derived Astrocytes Primary Cell NCC20--PZ61 Rat Brain Striatum-derived Astrocytes Primary Cell NCC20--PZ4- Rat Brain Cortex-derived Astrocytes Primary Cell NCL-2103-P26 Rat Cerebellar Astrocytes, Cryopreserved, Neonatal Primary Cell NCL-2103-P11 Rat Astrocytes, Cryopreserved, Neonatal Primary Cell NCL-2105-P173-AM Adult Rat Hippocampal Astrocytes - SV40, Immortalized Immortalized Cell Cutting Edge Tools for Neuroscience Research

  10. Microglial Cells Microglia are commonly described as the immune cells of the brain, with key roles in brain development, neurogenesis, synaptic plasticity and homeostatic maintenance. Creative Biolabs' Human iPSC-derived Microglia provide a reproducible, physiologically-relevant model in an easy-to-use, assay- ready format for investigating neuroglia involvement in neurodegeneration and neurodevelopment. Our iPSC-derived Microglia deliver the advantage that they provide an almost infinite source of microglia from a single donor with a normal karyotype. Our iPSC-derived Microglia also express the microglia-specific marker TMEM11- along with myeloid markers TREM2 and IBA-1. These phenotypes make iPSC-derived Microglia suitable models for investigating neuroinflammation in Alzheimer’s disease, multiple sclerosis and Parkinson’s disease. We also offer a fully optimized serum-free Microglia Maintenance Medium to promote and support the maintenance of microglia. Selected Microglial Cells Selected Microglial Cells Human Microglia Cat. Product Name Cell Type NCL-7P018 iNeu™ Human iPSC-derived Microglia Primary Cell NCL-7P016 iNeu™ Human iPSC-derived Microglia, Isogenic Control Primary Cell NCL-2108P38 Human Microglia Cell Line HMC3, Immortalized Immortalized Cell NCL-2105-P337-AM Human Microglia-GFP, Immortalized Immortalized Cell NCL-2105-P341-AM Human Microglia-RFP, Immortalized Immortalized Cell NCL-7P014 iNeu™ Microglia AD TREM2 HO, Disease Model Disease Model NCL-7P015 iNeu™ Microglia AD TREM2 HZ, Disease Model Disease Model NCL-7P036 iNeu™ Microglia AD APOE E4/E4, 11--5, Disease Model Disease Model NCL-7P037 iNeu™ Microglia AD APOE E4/E4, 11--3, Disease Model Disease Model NCL-7P038 iNeu™ Microglia AD APOE E4/E4, 12037, Disease Model Disease Model NCL-7P03- iNeu™ Microglia AD APOE E4/E4, 12061, Disease Model Disease Model NCL-7P040 iNeu™ Microglia AD APOE E2/E4, 11-68, Disease Model Disease Model NCL-7P050 iNeu™ Microglia TREM2 R47H, 11-6-, Disease Model Disease Model NCL-7P051 iNeu™ Microglia ABCA7 G1527A, 12000, Disease Model Disease Model NCL-7P020 iNeu™ Microglia Rett Syndrome MECP2, Disease Model Disease Model Mouse Microglia Cat. Product Name Cell Type NCL-21P6-081 Mouse Microglia from CD1 Primary Cell NCL-21P6-082 Mouse Microglia from C57BL/6 Primary Cell NCL-2103-P28 Mouse Microglia, Cryopreserved Primary Cell NCL-2105-P210-AM Mouse Microglia SIM-A-, Immortalized Immortalized Cell NCL-2108P32 Mouse Microglia BV-2, Immortalized Immortalized Cell Rat Microglia Cat. Product Name Cell Type NCL-2105-P35--AM Rat Primary Microglia Primary Cell NCL-2103-P1- Rat Primary Microglia, Neonatal Primary Cell NCL2110P015 Rat Hippocampal Microglia Primary Cell NCL-2106-S7- Rat Cochlear Microglial Cell Line Primary Cell NCL2110P037 Rat Microglia Cell Line HAPI, Immortalized Immortalized Cell NCL-21P6-222 Rat Cochlear Microglial Cell Line, Immortalized Immortalized Cell Cutting Edge Tools for Neuroscience Research

  11. Oligodendrocytes Oligodendrocytes are a type of large glial cell found in the central nervous system. Oligodendrocytes produce the myelin sheath insulating neuronal axons (analogous to Schwann cells in the peripheral nervous system), although some oligodendrocytes (called satellite oligodendrocytes) are not involved in myelination. Creative Biolabs' Human Oligodendrocyte Differentiation Kit contains Human Oligodendrocyte Progenitor Cells (OPCs) along with optimized media for their expansion and spontaneous differentiation into mature oligodendrocytes. Human OPCs can be used for a variety of research applications including studies of neurotoxicity, co-culture applications and screening for molecules that induce or inhibit preferential differentiation to mature oligodendrocytes. Selected Oligodendrocytes Selected Oligodendrocytes Human Oligodendrocyte Kit Cat. Product Name NCL200506ZP Human Oligodendrocyte Progenitors (OPCs) NCC200524ZP Human Oligodendrocyte Differentiation Kit NCC200527ZP Human Oligodendrocyte Characterization Kit Rat Oligodendrocyte Cat. Product Name NCL-21P6-0-4 Rat Oligodendrocyte Progenitor Cells Cutting Edge Tools for Neuroscience Research

  12. Schwann Cells Oligodendrocytes are a type of large glial cell found in the central nervous system. Oligodendrocytes produce the myelin sheath insulating neuronal axons (analogous to Schwann cells in the peripheral nervous system), although some oligodendrocytes (called satellite oligodendrocytes) are not involved in myelination. Creative Biolabs' Human Oligodendrocyte Differentiation Kit contains Human Oligodendrocyte Progenitor Cells (OPCs) along with optimized media for their expansion and spontaneous differentiation into mature oligodendrocytes. Human OPCs can be used for a variety of research applications including studies of neurotoxicity, co-culture applications and screening for molecules that induce or inhibit preferential differentiation to mature oligodendrocytes. Selected Schwann Cells Selected Schwann Cells Human Schwann Cells Cat. Product Name Cell Type NCL-2103-P106 Human Schwann Cells Primary Cell NCL2110P107 Human Schwann Cell, Immortalized Immortalized Cell Mouse Schwann Cells Cat. Product Name Cell Type NCL-21P6-060 Mouse Schwann Cells from CD1 Primary Cell NCL-21P6-061 Mouse Schwann Cells from C57BL/6 Primary Cell NCL-2105-P167-IX Mouse Schwann Cells Primary Cell NCL-2105-P223-AM Mouse Schwann Cells, Immortalized Immortalized Cell NCL-2105-P168-AM Mouse Schwann Cells from C57BL/6, Immortalized Immortalized Cell NCL-2105-P1-8-AM Mouse alpha-GalA-/o Schwann Cells, Immortalized Immortalized Cell NCL-2105-P207-AM Mouse Hexb-/- Schwann Cells (1113C1), Immortalized Immortalized Cell NCL-2105-P214-AM Mouse NPCNIH Schwann Cells (573C10), Immortalized Immortalized Cell NCL-2108P158 Mouse Schwann Cell (1-70C3), Immortalized Immortalized Cell NCL-2105-P224-AM Mouse Schwann Cells (IMS32), Immortalized Immortalized Cell NCL-2105-P225-AM Mouse Schwann Cells (IKARS1), Immortalized Immortalized Cell NCL-2105-P226-AM Mouse Schwann Cells (IWARS1), Immortalized Immortalized Cell NCL-2108P24 Mouse Schwann Cell Line SW10, Immortalized Immortalized Cell Rat Schwann Cells Cat. Product Name Cell Type NCL-21P6-0-5 Rat Schwann Cells Primary Cell NCL-2108P05 Rat Schwann Cells RSC-6, GFP, Immortalized Immortalized Cell NCL-2108P21 Rat Schwann Cells RSC-6, Immortalized Immortalized Cell NCL-2105-P244-AM Rat Schwann Cells (IFRS1), Immortalized Immortalized Cell Cutting Edge Tools for Neuroscience Research

  13. Neurological Disease Cell Models Translation from in vitro models & assays into animal models are critical to understanding the progression of neurological disease while providing a complete interactive physiology to understand the pharmacokinetics and pharmacodynamics of a candidate. We have developed robust and reproducible in vitro models and in vivo pharmacology studies that are validated for multiple assay platforms and reliable tools to screen small molecules to biologics. Applications of Cell Applications of Cell- -Based Models: Based Models: DISEASE MODELING. Generate patient-specific human "disease-in-a-dish" models. DRUG DISCOVERY. Screen drug candidates on physiologically relevant human cell types, including diseased cells. TOXICITY SCREENING. Evaluate neurotoxicity on differentiated human neural cell types. CELL THERAPY VALIDATION. Generate human neural cell types for pre-clinical validation of potential cell therapy applications. Selected Selected Neurological Neurological Disease Cell Models Disease Cell Models Gene-edited Disease Model Cat. Product Name Disease Cell Type NCL-7P001 iNeu Motor Neurons ALS TDP43 Q331K, Disease Model Amyotrophic Lateral Sclerosis Gene-edited Disease Model NCL-7P002 iNeu Motor Neurons ALS TDP43 M337V, Disease Model Amyotrophic Lateral Sclerosis Gene-edited Disease Model NCL-7P004 iNeu Motor Neurons ALS TDP43 Q331K Kit, Disease Model Amyotrophic Lateral Sclerosis Gene-edited Disease Model NCL-7P005 iNeu Motor Neurons ALS TDP43 M337V Kit, Disease Model Amyotrophic Lateral Sclerosis Gene-edited Disease Model NCL-2105-P133-IX iNeu Motor Neurons (SOD1 mutant, A4V, HOM) Amyotrophic Lateral Sclerosis Gene-edited Disease Model NCL-7P012 iNeu Microglia AD TREM2 HO Kit, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P013 iNeu Microglia AD TREM2 HZ Kit, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P014 iNeu Microglia AD TREM2 HO, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P015 iNeu Microglia AD TREM2 HZ, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P031 iNeu Microglia AD APOE E4/E4 Kit, 11--3, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P032 iNeu Microglia AD APOE E4/E4 Kit, 11--5, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P033 iNeu Microglia AD APOE E4/E4 Kit, 12037, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P034 iNeu Microglia AD APOE E4/E4 Kit, 12061, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P035 iNeu Microglia AD APOE E2/E4 Kit, 11-68, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P036 iNeu Microglia AD APOE E4/E4, 11--5, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P037 iNeu Microglia AD APOE E4/E4, 11--3, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P038 iNeu Microglia AD APOE E4/E4, 12037, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P03- iNeu Microglia AD APOE E4/E4, 12061, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P040 iNeu Microglia AD APOE E2/E4, 11-68, Disease Model Alzheimer’s Disease Gene-edited Disease Model NCL-7P026 iNeu DopaNeurons PD SNCA A53T HZ Kit, Disease Model Parkinson’s Disease Gene-edited Disease Model NCL-7P027 iNeu DopaNeurons PD SNCA A53T HZ, Disease Model Parkinson’s Disease Gene-edited Disease Model NCL-7P020 iNeu Microglia Rett Syndrome MECP2, Disease Model Rett Syndrome Gene-edited Disease Model NCL-2101-ZP06 iNeu Neural Stem Cells - AD Patient (APOE4 HOM) Alzheimer’s Disease Gene-edited Disease Model NCL-2101-ZP07 iNeu Neural Stem Cells - AD Patient (PSEN1 L286V) Alzheimer’s Disease Gene-edited Disease Model NCL-2101-ZP08 iNeu Neural Stem Cells - AD Patient (PSEN1 M146L) Alzheimer’s Disease Gene-edited Disease Model NCL-2101-ZP0- iNeu Neural Stem Cells - AD Patient (PSEN1 A246E) Alzheimer’s Disease Gene-edited Disease Model Cutting Edge Tools for Neuroscience Research

  14. Neurological Disease Cell Models Donor-derived Disease Model Cat. Product Name Disease Cell Type NRZP-0622-P28 iNeu™ Human Neural Stem Cells - Alzheimer’s Disease Patient, Donor 1 Alzheimer’s Disease Donor-derived Disease Model iNeu™ Human Neural Stem Cells - Frontotemporal Dementia (FTD) Patient, Donor 4 iNeu™ Human Neural Stem Cells - Frontotemporal Dementia (FTD), Paget’s Disease Patient, Donor 6 NRZP-0622-P31 Frontotemporal Dementia (FTD) Donor-derived Disease Model Frontotemporal Dementia (FTD), Paget’s Disease NRZP-0622-P33 Donor-derived Disease Model iNeu™ Human Neural Stem Cells - Frontotemporal Dementia, ALS Patient, Donor 8 Frontotemporal Dementia, Amyotrophic Lateral Sclerosis NRZP-0622-P35 Donor-derived Disease Model iNeu™ Human Neural Stem Cells - Behavioural Variant Frontotemporal Dementia (bvFTD) Patient, Donor 10 Behavioural Variant Frontotemporal Dementia (bvFTD) NRZP-0622-P37 Donor-derived Disease Model NRZP-0622-P41 iNeu™ Human Neural Stem Cells - Mucolipidosis IV (ML4) Patient, Donor 14 Mucolipidosis IV (ML4) Donor-derived Disease Model NRZP-0622-P45 iNeu™ Human Neural Stem Cells - Nasu-Hakola Disease Patient, Donor 18 Nasu-Hakola Disease Donor-derived Disease Model iNeu™ Human Neural Stem Cells - Nasu-Hakola Disease (familial control) Patient, Donor 20 Nasu-Hakola Disease (familial control) NRZP-0622-P47 Donor-derived Disease Model NRZP-0622-P48 iNeu™ Human Neural Stem Cells - Parkinson’s Disease Patient, Donor 21 Parkinson’s Disease Donor-derived Disease Model iNeu™ Human Neural Stem Cells - Parkinsonism/Machado-Joseph Disease (SCA3) Patient, Donor 32 Parkinsonism/MachAlzheimer’s Diseaseo-Joseph Disease (SCA3) NRZP-0622-P5- Donor-derived Disease Model iNeu™ Human Neural Stem Cells - Amyotrophic Lateral Sclerosis (ALS) Patient, Donor 36 Amyotrophic Lateral Sclerosis (Amyotrophic Lateral Sclerosis) NRZP-0622-P63 Donor-derived Disease Model Amyotrophic Lateral Sclerosis (Amyotrophic Lateral Sclerosis) (unaffected) iNeu™ Human Neural Stem Cells - Amyotrophic Lateral Sclerosis (ALS) (unaffected) Patient, Donor 38 NRZP-0622-P65 Donor-derived Disease Model iNeu™ Human Neural Stem Cells - Charcot-Marie-Tooth Disease, Type 4J (CMT4J) Patient, Donor 3- Charcot-Marie-Tooth Disease, Type 4J (CMT4J) NRZP-0622-P66 Donor-derived Disease Model iNeu™ Human Neural Stem Cells - Dentatorubral-Pallidoluysian Atrophy (DRPLA) Patient, Donor 40 Dentatorubral-Pallidoluysian Atrophy (DRPLA) NRZP-0622-P67 Donor-derived Disease Model NRZP-0622-P71 iNeu™ Human Neural Stem Cells - Friedreich’s Ataxia Patient, Donor 44 Friedreich’s Ataxia Donor-derived Disease Model iNeu™ Human Neural Stem Cells - Friedreich’s Ataxia (control) Patient, Donor 48 iNeu™ Human Neural Stem Cells - Friedreich’s Ataxia (familial control) Patient, Donor 4- NRZP-0622-P75 Friedreich’s Ataxia (control) Donor-derived Disease Model NRZP-0622-P76 Friedreich’s Ataxia (familial control) Donor-derived Disease Model NRZP-0622-P77 iNeu™ Human Neural Stem Cells - Huntington’s Disease Patient, Donor 50 Huntington’s Disease Donor-derived Disease Model iNeu™ Human Neural Stem Cells - Huntington’s Disease RCi004-B Patient, Donor 53 iNeu™ Human Neural Stem Cells - Spinal and Bulbar Muscular Atrophy (SBMA) Patient, Donor 55 iNeu™ Human Neural Stem Cells - Spinocerebellar Ataxia Type 2 (SCA2) Patient, Donor 56 iNeu™ Human Neural Stem Cells - Spinocerebellar Ataxia Type 7 (SCA7) Patient, Donor 62 iNeu™ Human Neural Stem Cells - Spinocerebellar Ataxia Type 6 (SCA6) Patient, Donor 63 iNeu™ Human Neural Stem Cells - Spinocerebellar Ataxia Type 3 (SCA3) Patient, Donor 64 NRZP-0622-P80 Huntington’s Disease RCi004-B Donor-derived Disease Model Spinal and Bulbar Muscular Atrophy (SBMA) Spinocerebellar Ataxia Type 2 (SCA2) Spinocerebellar Ataxia Type 7 (SCA7) Spinocerebellar Ataxia Type 6 (SCA6) Spinocerebellar Ataxia Type 3 (SCA3) NRZP-0622-P82 Donor-derived Disease Model NRZP-0622-P83 Donor-derived Disease Model NRZP-0622-P8- Donor-derived Disease Model NRZP-0622-P-0 Donor-derived Disease Model NRZP-0622-P-1 Donor-derived Disease Model NCL-2105-P130-IX iNeu Human Motor Neurons - ALS Patient, Sporadic Amyotrophic Lateral Sclerosis Donor-derived Disease Model NCL-2101-ZP11 iNeu Human Neural Stem Cells - Epilepsy Patient Epilepsy Donor-derived Disease Model NCL-2101-ZP12 iNeu Human Neural Stem Cells - Trisomy X Patient Trisomy X Donor-derived Disease Model NCL-2108-P007 iNeu Human Neural Progenitor Cell Line, AD Patient Alzheimer’s Disease Donor-derived Disease Model Assay Cell Line Models Cat. Product Name Cell Type NCL2110P230 APP Processing Assay Cell Line [Alzheimer’s Disease (AD) Model] Assay Model NCL2110P231 FUS/TLS Stress Granules Assay Cell Line [Amyotrophic Lateral Sclerosis (ALS) Model] Assay Model NCL2110P232 Gamma Secretase Activity Assay Cell Line [Alzheimer’s Disease (AD) Model] Assay Model NCL2110P234 Parkin Mitochondrial Recruitment Assay Cell Line [Parkinson’s Disease (PD) Model] Assay Model NCL2110P235 Tau Phosphorylation Assay Cell Line [Alzheimer’s Disease (AD) Model] Assay Model NCL2110P236 TDP-43 Stress Granules Assay Cell Line [Amyotrophic Lateral Sclerosis (ALS) Model] Assay Model NCL2110P337 Parkinsonism Cell Line, Disease Model Assay Model Cutting Edge Tools for Neuroscience Research

  15. Neural Tissues Extensive Neural Tissue Biorepository from Healthy and Diseased Donors ! Extensive Neural Tissue Biorepository from Healthy and Diseased Donors ! Creative Biolabs offers a comprehensive repository of neural tissue samples, covering multiple regions of the brain and spinal cord from many species and tissue types. Certified tissues are available as OCT frozen blocks & snap-frozen samples, FFPE blocks, FFPE tissue arrays, frozen tissue arrays, frozen tissue sections, FFPE tissue sections, FFPE tissue panels, as well as fresh tissue. We have a wide range of donors and provide both healthy and diseased tissue. Also available: Total RNA– cDNA– Genomic DNA– Total Protein Human Tissue Human Tissue - Adult and Fetal Normal - Tumour and Adjacent Tissue - Diseased tissues including Alzheimer's Disease, Parkinson's Disease and Dementia Multiple Species Available Multiple Species Available - Mouse - Rhesus Monkey - Cynomolgus Monkey - Marmoset - Guinea Pig - Cat - Chicken - Dog - Horse - Bovine - Rat - Rabbit - Hamster - Nude Mouse - Mini Pig - Pig Tissue Dissociation: Tissue Dissociation: Creative Biolabs has developed Neural Tissue Dissociation Kits used for the gentle and efficient generation of single-cell suspensions from neural tissues. The Neural Tissue Dissociation Kit - Postnatal Neurons has been optimized for the special needs of sensitive postnatal neurons during dissociation. We also offers highly purified collagenase free of any animal-based components. For research applications, non-GMP grade Collagenase NB4 Standard Grade and Collagenase NB 5 Sterile Grade are economical alternatives with comparable enzymatic properties to Collagenase NB 6 GMP Grade. Ordering Information: Ordering Information: Cat. Product Name NRZP-0622-ZP15 Neural Tissue Dissociation Kit (P) – Postnatal Neurons NRZP-0622-ZP16 Neural Tissue Dissociation Kit (T) – Postnatal Neurons NRZP-0622-ZP17 Brain Tumor Dissociation Kit (P), Human and Mouse NRZP-0622-ZP14 Adult Brain Dissociation Kit, Mouse and Rat NRZP-0622-ZP390 Collagenase NB 4 Standard Grade NRZP-0622-ZP389 Collagenase NB 5 Sterile Grade NRZP-0622-ZP394 Collagenase NB 6 GMP Grade NRZP-0622-ZP396 Neutral Protease NB GMP Grade Cutting Edge Tools for Neuroscience Research

  16. Neural Cell Culture Media and Supplements We supply neural cell culture medium optimized to support undifferentiated growth both as adherent cultures or neurosphere suspensions. We also provide medium, supplements and growth factors to differentiate neural stem cells and to maintain long- term cultures of differentiated cells. In addition to culture mediums, Creative Biolabs also supplies all supporting reagents to characterize neural stem cells including nestin antibodies as well as differentiated neurons using βIII-tubulin antibodies, oligodendrocytes using O3 antibodies and astrocytes using GFAP antibodies. Ordering Information: Ordering Information: Growth Medium Cat. Product Name CAT#: NCC20-9PZ02 Astrocyte Growth Medium NCL-21P6-226 Microglial Cell Growth Medium NCC-2101-ZP14 Striatal Neuron Growth Medium NRZP-0522-ZP1151 Oligodendrocyte Growth Media NCL-21P6-105 Oligodendrocyte Precursor Cell Growth Medium NCC20-9PZ10 Primary Neuron Growth Medium NCC2009PZ17 Retinal Pigment Epithelial Cell Growth Medium Kit NCC20-9PZ26 Endothelial Cell Growth Medium NCC-2103-P65 Schwann Growth Medium NCL-2105-P140-IX Human Neural Stem Cell Growth Medium Maintenance Medium Cat. Product Name NCC200631ZP StemTes™ A Maintenance Medium NCC-2101-ZP26 Microglia Maintenance Medium NCC-2101-ZP15 Sensory Neuron Maintenance Medium NCC-2101-ZP24 Motor Neuron Maintenance Medium NCC-2101-ZP25 Astrocyte Maintenance Medium NCL-2105-P119-IX Cortical Neuron Maintenance Medium Differentiation Medium Cat. Product Name NCL-21P6-106 Oligodendrocyte Precursor Cell Differentiation Medium NCC200538ZP ES/iPS Neuronal Differentiation Medium Neural Supplements Cat. Product Name NCL-7P062 Nervous System Supplement NCL-21P6-124 Astrocyte Growth Supplement NCL-21P6-118 Epithelial Cell Growth Supplement NCL-21P6-116 Fibroblast Growth Supplement NCL-21P6-114 Endothelial Cell Growth Supplement NCC200512ZP NeuroInduc™ Neural Stem and Progenitor Cells Differentiation Supplement NCC200600ZP NeuroInduc™ N2 Supplement-A NCC200605ZP NeuroInduc™ N2 Supplement-B NRZP-0622-ZP403 GS21 Neural Supplement NCC-2101-ZP17 Human/Murine/Rat BDNF [CAT#:] NCC-2101-ZP19 Human beta-NGF NCC-2101-ZP20 Human NT-3 Cutting Edge Tools for Neuroscience Research

  17. Neural Cell Culture Matrices Laminin for Neural Cell Attachment Laminin for Neural Cell Attachment Laminins (heterotrimers composed of α, β, and γ chains), are multifunctional glycoproteins present in basement membranes. Laminin has long been an important mainstay of neural cell culture as coating substrates and is also used as a supplement of culture medium to enhance growth of human neural stem cells. We provide a range of high quality laminin products that are ideally suited as tools for neural cell culture to allow you to select the most suitable version for your research. Ordering Information: Ordering Information: Cat. Product Name NRZP-0622-ZP398 Mouse Laminin I NRZP-0622-ZP399 Antibiotic-Free Mouse Laminin I NRZP-0622-ZP400 Stem Cell Qualified Mouse Laminin I NRZP-0622-ZP401 3D Culture Matrix Laminin I NRZP-0622-ZP402 Poly-D-Lysine & Laminin Coating Solution Extracellular Matrix for Neurosphere Formation Extracellular Matrix for Neurosphere Formation Neurospheres demonstrated the first unequivocal evidence that cells derived from adult brain can have stem cell properties and remain a useful tool for the in vitro study of neural stem cells. Applications include analysis of selfrenewal capacity, potency, neural development and neurogenesis. We provide an optimized spheroid formation matrix to help with consistent generation of neurospheres for use in your research. Ordering Information: Ordering Information: Cat. Product Name NRZP-0622-ZP397 Neurosphere Formation Matrix

  18. Neural Cell Transfection Optimized transfection reagents tailored for neural cells! Optimized transfection reagents tailored for neural cells! Physiologically relevant models, such as primary neurons and small animal models, increase the need for new nucleic acid delivery tools. One of the greatest challenges is the ability to manipulate the desired cell models that are traditionally difficult to transfect, including primary neurons and neural stem cells. Methods typically used have not met these needs—reagent- mediated DNA transfection is inefficient for nuclear entry; electroporation requires cell disruption and special instrumentation, and is expensive; and virus-mediated transduction can be very time-consuming. To facilitate the use of more relevant cell models, we have developed NeuroIn™ Transfection Reagent, which we recommend as the primary gene delivery solution (Fig.1). Figure 1. Recommended transfection methods, by cell type. Ordering information: Ordering information: Cat. Product Name NRZP-0622-ZP377 NeuroIN™ mRNA Transfection Reagent NRZP-0622-ZP378 NeuroIN™ DNA Transfection Reagent, Lipo 3000 NRZP-0622-ZP37- NeuroIN™ DNA Transfection Reagent, Lipo 2000 NRZP-0622-ZP380 NeuroIN™ Invivo Brain Transfection Reagent, 3.0 NRZP-0622-ZP381 NeuroIN™ RNAi Transfection Reagent Product selection guide Product selection guide We offer a variety of other gene delivery options based on your research needs, including lentiviral delivery and physical methods such as electroporation. However, there are advantages and limitations for each method based on the cell models being used and the end goal of the experiment: gene expression or gene knockdown. An overview of our most effective delivery solutions for neurobiology research is shown in Table 1. Table 1. Gene delivery products for neurobiology research by nucleic acid type. Table 1. Gene delivery products for neurobiology research by nucleic acid type. Product Nucleic acid type Cell model Performance Cell viability Ease of use Primary cells, stem cells, and difficult-to- transfect cells NeuroIN™ mRNA Transfection Reagent mRNA +++ ++++ ++++ Easy- and difficult-to-transfect immortalized cell lines, viral delivery NeuroIN™ DNA Transfection Reagent, Lipo 3000 DNA ++ ++++ ++++ NeuroIN™ DNA Transfection Reagent, Lipo 2000 DNA Easy-to-transfect cells, primary neurons + ++++ ++++ NeuroIN™ Invivo Brain Transfection Reagent, 3.0 siRNA, mRNA In vivo directbraininjection ++ ++ ++ NeuroIN™ RNAi Transfection Reagent siRNA All neuronal cell models (gene knockdown) ++++ ++++ ++++ Cutting Edge Tools for Neuroscience Research

  19. Neural Cell Cryopreservation Keeping your cells safe with the CELLBANKER Series! Keeping your cells safe with the CELLBANKER Series! There are numerous protocols available for cryopreserving neural stem cells (NSCs) derived from human embryonic stem cells; the primary objective of these methods are the recovery of the cells post-thaw and the retention of their multipotent properties. Creative Biolabs supplies cutting edge cryopreservation reagents to meet the demands of your neural cell research. Our high performance and quality assured CELLBANKER cryopreservation solutions ensure stable long-term storage of cells. CELLBANKER is a series of easy-to-use cell freezing media with defined formulations, available in serum and serum-free formulations to successfully cryopreserve the most sensitive mammalian cells. Figure 1. Recommended transfection methods, by cell type. Product selection guide Product selection guide - CELL-BANKER 1 was launched in 1--2 and now has a significant history of reliable, consistent and high viability recoveries post-cryopreservation. Contains serum, DMSO, glucose, salts and buffer. - CELLBANKER 2 is a chemically defined serum-free cell freezing medium that allows cell cryopreservation directly at -80˚C without requiring a rate controlled freezer. Contains no animal derived products and is guaranteed sterile. - STEM-CELLBANKER is a chemically defined xeno-free freezing medium optimized for stem cells and iPS cells storage as well as other valuable cells. It is free of serum and animal derived components and contains only European or US Pharmacopoeia graded ingredients. Use STEM-CELLBANKER to achieve consistently high cell viability post-thaw, even over extended long-term storage, while maintaining cell pluripotency, normal karyotype and proliferation ability. Ordering information: Ordering information: Cat. Product Name NRZP-0622-ZP382 CELLBANKER 1 (100ml) NRZP-0622-ZP383 CELLBANKER 2 (100ml) NRZP-0622-ZP384 STEM-CELLBANKER - GMP Grade (20ml) Cutting Edge Tools for Neuroscience Research

  20. USA UK 167-16-Great Portland Street, 5th Floor, London, W1W 5PF SUITE 203, 17 Ramsey Road, Shirley, NY 11-67, USA Tel: 44-207-0-7-1828 Tel: 1-631-357-2254 Fax: 1-631-207-8356 Email: info@creative-biolabs.com Email: info@creative-biolabs.com

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