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Vocabulary. Macromoleculeterm used to describe large molecules such as carbohydrates, lipids, proteins, and nucleic acidsMonomerthe repeating unit molecules of polymersPolymera long chainlike molecule consisting of repeating building-block molecules linked by covalent bondsincludes proteins, carbohydrates, and nucleic acids.
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1. IB Biology Review Chapter 5: Macromolecules
2. Vocabulary Macromolecule
term used to describe large molecules such as carbohydrates, lipids, proteins, and nucleic acids
Monomer
the repeating unit molecules of polymers
Polymer
a long chainlike molecule consisting of repeating building-block molecules linked by covalent bonds
includes proteins, carbohydrates, and nucleic acids
3. What are the four groups of macromolecules? Carbohydrates
Lipids
Proteins
Nucleic Acids
4. Examples of Monomers What are the monomers of
Carbohydrates
Simple sugars (monosaccharides) like glucose and fructose make polysaccharides
Proteins
20 different amino acids form polypeptides
Nucleic Acids
Nucleotides (A, T, G, C, and U) form DNA and RNA
5. How are monomers linked and unlinked? Linked by condensation/dehydration reaction
A molecule of water is removed to form a bond
Anabolic reaction
Unlinked by hydrolysis reaction
A molecule of water is added to break a bond
Catabolic reaction
6. Two Types of Covalent Bonds that Join Monomers Saccharide bonds join two adjacent monosaccharides
Peptide bonds join two adjacent amino acids
7. MC-1.Which of the following reactions occurs when a dipeptide is formed from amino acids? A. hydrolysis
B. denaturation
C. condensation
D. oxidation
Correct answer: C
8. Special Types of Bonds Two monosaccharides are joined by a
saccharide bond
Two amino acids are joined by a
peptide bond
9. DNA Structure 1. Alternating sugar and phosphate molecules
2. Bases are towards center (A/T) (G/C)
3. Hydrogen bond connects adjacent base pairs
4. Double helix structure (twisted ladder of polynucleotides)
10. DNA Nucleotide Structure Deoxyribose (sugar) molecule binds to phosphate at the Carbon III and V positions
11. MC-2. What is the composition of the backbone of DNA? A. alternating sugar and phosphate molecules
B. complementary base pairs
C. alternating sugar and base molecules
D. a polysaccharide
Correct answer: A
12. Structure of Ribose and Glucose Ribose has five carbon molecules
Glucose has six carbon molecules
Be able to draw these structures!
13. IB Required Monosaccharides IB wants you to be able to list the following monosaccharides
Glucose
Ribose
Fructose
Glyceraldehyde
Galactose
Monosaccharides always have a 1:2:1 carbon: hydrogen: oxygen ratio
Example: Glucose is C6H12O6
14. IB Required Disaccharides IB wants you to be able to list the following disaccharides
Sucrose (glucose and fructose) table sugar
Lactose (glucose and galactose) milk sugar
Maltose (glucose and glucose) starch in seeds
15. IB Required Polysaccharides IB wants you to be able to list the following polysaccharides
Cellulose cell walls
Glycogen energy storage in animals
Starch energy storage in plants
16. Structure of Fatty Acids IB needs you to know this structure:
Where n stands for the different number of carbon molecules that can be added or removed to change the length of the chain
17. Structure of Fatty Acids Saturated Fatty Acids
Have no double carbon bonds in any of three tails
Usually solid at room temperature
Example: butter
Unsaturated Fatty Acids
Have at least one double carbon bond in tails
Usually liquid at room temperature
Example: cooking oil
Which is better for you?
Unsaturated fatty acids
18. Phospholipid Structure Molecules in the phospholipid bilayer in cell membrane
19. Lipid Function Energy storage / energy supply
Hormone production
Cushioning / protection
Insulation
Constituent of cell membrane (part of phospholipid bilayer)
20. Energy Storage Carbohydrates
Stored as glycogen in animals (in liver)
Stored as starch in plants (in roots)
More easily digested than lipids so energy can be released more quickly
Lipids
Stored as fat in animals
Long-term energy storage
More energy per gram than carbohydrates
21. Health Risks of Lipids Saturated fatty acids cause high cholesterol
Athersclerosis / narrowing of (lumen of) arteries
Hypertension / high blood pressure
Obesity / overweight
22. Amino Acid Structure Twenty different amino acids
All share the same base:
What differs in each amino acid is “R” or the side chain
23. Protein Structure Primary Structure
The unique sequence of amino acids, each linked together by a peptide bond
Secondary Structure
The Beta-pleated sheets and Alpha-helix structures
Tertiary Structure
in globular proteins involves the folding of polypeptides. This folding pattern is stabilized by several types of bonds including hydrogen bonds and ionic bonds
Quaternary Structure
of proteins is the linking together of two or more polypeptide subunits. An example of this is hemoglobin which has 4 subunits
Example: Hemoglobin has four subunits
24. Protein Function A protein’s shape is the key to its function
Know at least four functions and an example
Hormones: Insulin helps regulate blood sugar
Enzymes: Catalase catalyzes breakdown of hydrogen peroxide waste in blood
Transport Proteins: Ion channels and proton pumps for active transport in cell membrane
Structural Proteins: Collagen, keratin, tubulin, fibroin
Defense: Antibodies are proteins
Receptors: Hormone receptor or neurotransmitter receptor on cell surface
25. MC-3. Which is not a primary function of protein molecules? A. hormones
B. energy storage
C. transport
D. structure
Correct answer: B
26. MC- 4. Which of the following are connected by a hydrogen bond? A. the hydrogen and oxygen atoms of a water molecule
B. base pairs of a DNA molecule
C. two amino acid molecules of a dipeptide
D. two glucose molecules in a disaccharide
Answer: B
27. 1. Draw a diagram of the molecular structure of a portion of DNA. (4 marks) sugar-phosphate backbone;
bases toward centre;
A—T, G—C base pair;
hydrogen bonds labelled;
twisted ladder;
two polynucleotides (two strands shown);
28. 2. To which parts of the deoxyribose molecule do phosphates bind in DNA? (1 mark) A. I and V
B. III and V
C. II and III
D. III and IV
Correct answer: B
29. 3. Which molecules represents ribose? (1 mark) Correct answer: D
30. 4. Outline how monosaccharides are converted into polysaccharides. (2 marks) condensation;
involves the removal of water to join monosaccharides together
catalysed by enzymes;
consists of many monosaccharides linked (glycosidic) to make polysaccharide;
31. 5. Describe the use of carbohydrates and lipids for energy storage in animals. (5 marks) Answers must discuss both carbohydrates and lipids to receive full marks.
carbohydrates:
stored as glycogen (in liver);
short-term energy storage;
more easily digested than lipids so energy can be released more quickly;
more soluble in water for easier transport;
lipids:
stored as fat in animals;
long-term energy storage;
more energy per gram than carbohydrates;
lipids are insoluble in water less osmotic effect
32. 6. Draw the structure of a fatty acid. (1 mark)
33. 7. Correct answer: D
34. 8. Outline the production of a dipeptide by a condensation reaction. Include the structure of a generalized dipeptide in your answer. (5 marks) carboxyl / COOH group of one amino acid reacts with amine /
NH2 group of another;
water / H2O is eliminated;
These steps can be shown
diagrammatically, e.g.
peptide / covalent bond is produced;
diagram of dipeptide, with peptide bond shown; e.g.
Award [1] if the two amino acids forming the dipeptide are shown correctly. The radicals can be shown as R or H. Award the second mark if the C-N bond is labeled as peptide bond or dipeptide bond. The label can include the H bonded to the N and the O double bonded to the C.
35. 9. List four functions of proteins, giving an example of each. (4 marks) Name of function and named protein must both be correct for the mark.
storage – zeatin (in corn seeds) / casein (in milk);
transport – hemoglobin / lipoproteins (in blood);
hormones – insulin / growth hormone / TSH / FSH / LH;
receptors – hormone receptor / neurotransmitter receptor / receptor in chemoreceptor cell;
movement – actin / myosin;
defence – antibodies / immunoglobin;
enzymes – catalase / RuBP carboxylase;
structure – collagen / keratin / tubulin / fibroin;
electron carriers – cytochromes;
pigments – opsin
active transport – sodium pumps / calcium pumps;
facilitated diffusion – sodium channels / aquaporins;
36. 10. Explain the significance of polar and non-polar amino acids. (5 marks) Non-polar amino acids have non-polar (neutrally charged) R groups. \
Polar amino acids have R chains with polar groups (charged either positive or negative).
Proteins with a lot of polar amino acids make the proteins hydrophyllic and therefore able to dissolve in water.
Proteins with many non-polar amino acids are more hydrophobic and are less soluble in water.
With these abilities, proteins fold themselves so that the hydrophilic ones are on the inner side and allows hydrophilic molecules and ions to pass in and out of the cells through the channels they form.
These channels are vital passages for many substances in and out of the cell.
37. 11. Outline the difference between fibrous and globular proteins, with reference to examples of each protein type. ( 4 marks) Fibrous proteins are in their secondary structure, which could be in the alpha helix or beta pleated forms.
They are made of a repeated sequence of amino acids that can be coiled tightly around in a pattern that makes it a very strong structure.
Two examples are keratin (in hair and skin) and collagen (in tendons, cartilage, and bones).
Globular proteins are in their tertiary or quaternary structure, which is folded, creating a globular, three-dimensional shape.
An example of globular proteins are all enzymes
38. 12. State one function of glucose and glycogen in animals, and cellulose and starch in plants. ( 4 marks) Glucose: Energy for Cellular respiration
Glycogen: Energy from this polysaccharides is stored in the liver of animals
Cellulose: Provides strength to cell walls
Starch: Energy from this polysaccharide is stored in roots of plants
39. 13. List several examples each of monosaccharides, disaccharides and polysaccharides ( 6 marks) Monosaccharides: Glucose, Fructose (fruit sugar) , Lactose (milk sugar), Ribose (in RNA)
Dissacharides: Sucrose (Glucose and Fructose), Maltose (Glucose and Glucose)
Polysacchrides: Starch (plants) , Glycogen (animals), and Cellulose (plants)
40. Chapter Five Quiz Excellent multiple choice quiz on Campbell Biology textbook CD or website
Go to Chapter 5: The Structure and Function of Macromolecules -> Activities Quiz
Use this to study!