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Replicative cycle of HIV-1 and Therapy

Replicative cycle of HIV-1 and Therapy. Entry. Maturation. Reverse Transcription. Integration. Polymerase and RNase H active sites of HIV-1 RT. 17-18 bp. p66. p51. p66. p51. DNA synthesis. dNTP. PPi. dNTP. PPi. DNAn. DNAn+1. DNAn+2.

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Replicative cycle of HIV-1 and Therapy

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  1. Replicative cycle of HIV-1 and Therapy Entry Maturation Reverse Transcription Integration

  2. Polymerase and RNase H active sites of HIV-1 RT 17-18 bp p66 p51

  3. p66 p51

  4. DNA synthesis dNTP PPi dNTP PPi DNAn DNAn+1 DNAn+2 ...

  5. Structures of NON-nucleoside analogue RT inhibitors (NNRTIs)

  6. HIV-1 RT Bound to a Non-Nucleoside RT Inhibitor (NNRTI) Active site Nevirapine

  7. HIV-1 RT Bound to a NNRTI + Surrounding NNRTI-associated Drug Resistance Mutations Active site Nevirapine Drug resistance mutations

  8. Structures of nucleoside analogue RT inhibitors (NRTIs) AZT d4T 3TC

  9. HIV-1 RT: Active Site and Nucleoside Analog Drug Resistance Mutations Active site Drug resistance mutations Incoming nucleotide

  10. HIV-1 Protease Bound to an Inhibitor Active site: Substrate Cleft: Indinavir

  11. HIV-1 Protease Bound to Inhibitor + Drug Resistance Mutations Active site: Substrate Cleft: “Major” mutations Indinavir “Minor” mutations

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