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Scale-up of Aerobic bioreactors

Scale-up of Aerobic bioreactors. Aerobic bioreactors. Most of the industrial bioprocesses are aerobic Oxygen is an important nutrient for microorganism for growth The oxygen transfer rate can control the overall rate of the bioprocess in aerobic bioreactors. Widely used types are.

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Scale-up of Aerobic bioreactors

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  1. Scale-up of Aerobic bioreactors

  2. Aerobic bioreactors • Most of the industrial bioprocesses are aerobic • Oxygen is an important nutrient for microorganism for growth • The oxygen transfer rate can control the overall rate of the bioprocess in aerobic bioreactors

  3. Widely used types are Stirred tank reactor Bubble column Air lift column

  4. Parameters affecting the Oxygen transfer rate • the system physical properties • the biochemical properties • the operational conditions(gas flow rate, stirrer tip speed) • the geometrical parameters of bioreactor (kind and size of bioreactor, design and number of stirrers, etc.) • The parameters in the first two groups are determined by the nature of the system and can not be altered freely; the last two groups depend on the process parameters and on the device used

  5. Steps of scale up… • Find geometric parameters of the larger scale bioreactor • Stirred tank reactor Vessel diameter, Height, Impeller diameter • Bubble column Height, Diameter • Use scale up criteria to determine operational parameters of the larger scale • Stirred tank reactor Impeller speed, Air flow rate • Bubble column Air flow rate

  6. Geometric correlations of a stirred tank reactor For Turbine blade impellers J H L W Di E D

  7. Scale-up criteria • Constant volumetric mass transfer coefficient(KLa) • Constant power consumption per unit volume(P/V) • Constant impeller tip speed(пND) • Constant Reynolds number(Re) • Constant dissolved oxygen concentration (CO2)

  8. Scale-up criteria Percentage of each criteria used in fermentation industry (Garcia & Gomez, 2009)

  9. Scale-up criteria (Garcia and Gomez,2009)

  10. Constant tip speed N1= Impeller speed of small bioreactor N2= Impeller speed of Large bioreactor Di1= Impeller diameter of small bioreactor Di2= Impeller diameter of large bioreactor

  11. Constant Reynolds number N = Impeller speed D = Impeller diameter ρL= Density of the liquid μL=Viscosity of the liquid

  12. Constant Power consumption per unit volume (Rushton’s equation) Ungassed power consumption , Np

  13. Constant Power consumption per unit volume (Rushton’s equation) Ungassed power consumption , Gassed power consumption ,

  14. Constant Power consumption per unit volume

  15. Constant volumetric mass transfer coefficient (kLa) • There are large no.of empirical correlations • Ex: empirical correlations to determine Kla for Newtonian fluids in stirred tank reactors (Garcia and Gomez,2009)

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