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Professor Michael J. Sailor UC San Diego Dept. of Chemistry and Biochemistry msailor@ucsd

The Uses of Nanosensors: From Smart Dust to Nano “Mother Ships” Jack Ealy Workshop La Jolla, CA July 2006. Professor Michael J. Sailor UC San Diego Dept. of Chemistry and Biochemistry msailor@ucsd.edu http://chem-faculty.ucsd.edu/sailor/. Death on the Danube. The Economist, 2/15/00.

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Professor Michael J. Sailor UC San Diego Dept. of Chemistry and Biochemistry msailor@ucsd

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  1. The Uses of Nanosensors: From Smart Dust to Nano “Mother Ships”Jack Ealy WorkshopLa Jolla, CA July 2006 Professor Michael J. Sailor UC San Diego Dept. of Chemistry and Biochemistry msailor@ucsd.edu http://chem-faculty.ucsd.edu/sailor/

  2. Death on the Danube The Economist, 2/15/00

  3. Environmental sampling Lab Field

  4. Need: • sensors • power sources Smart DustKris Pister, UCB (1996) • Available: • wireless radios • data processing • networkingprotocols

  5. Smart DustKris Pister, UCB (1996) • Need: • sensors • power sources

  6. Silicon vapor sensors

  7. Making a silicon nanostructure 20 mm Electrochemical machining of nanopores

  8. Silicon nanostructures mimic the beetle shell Calloodes grayanus 2 mm Chitin multilayer

  9. Silicon nanostructures mimic the beetle shell Silicon multilayer

  10. Silicon Microsensors

  11. William R. Freeman, M.D. and Lingyun Cheng, M.D.Jacobs Retina CenterUCSD

  12. Mother-Ships for Nanotherapies Porous silicon micro-particle in the eye color changes when particle releases drug

  13. Diagnostic Targeting Self-Destruct Sensor Activation Diagnostic Targeting Species Self-Destruct Sensor Trigger/Actuate Therapeutic Therapeutic Targeted Nanomachines UCSD Moores Cancer Center NIH nanoTUMOR center Erkki Ruoslahti, Burnham Inst. Sangeeta Bhatia, MIT Michael Sailor, UCSD Ruoslahti, Cancer Cell, 2002

  14. Backup slides

  15. Hazards of nanotechnology As with any new technology, reasonable concerns about potential hazards are appropriate. Asbestos fibers (Nikon, inc) University of Wisconsin, Madison Asbestos Management Program Heating/Chilling Plant: Furnace/Boiler Abatement (December 1997-January 1998)

  16. Hazards of nanotechnology Shvedova, A. A. et al. Exposure to carbon nanotube material: assessment of nanotube cytotoxicity using human keratinocyte cells. J. Toxicol. Environ. Health A66, 1909-1926 (2003). Derfus, A., Chan, W. & Bhatia, S. N. Probing the Cytotoxicity of Semiconductor Quantum Dots. Nano Lett. (2004). 5 nm CdSe (A. Paul Alivisatos, UC Berkeley)

  17. Making a silicon nanostructure 20 mm

  18. Encoded particles self-assemble

  19. Magnetic manipulation of microparticles Nature Mater.2004, 3, 896-899.

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