1 / 66

Tubulointerstitial disease of the KIDNEY

caprice
Download Presentation

Tubulointerstitial disease of the KIDNEY

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

    1. Tubulointerstitial disease of the KIDNEY

    6. How are tubules injured? Secondary to glomerular injury Secondary to vascular injury Primary target is tubules: ISCHEMIA TOXINS INFECTION IMMUNE ATTACK

    9. Syndromes resulting from tubulointerstitial injury: acute renal failure tubular dysfunction salt loosing nephropathy renal tubular acidosis acquired Fanconi syndrome chronic renal failure

    10. Acute renal failure in acute tubular necrosis: failed GFR hypoperfusion secondary to the cause vasoconstriction: renin-angiotensin back-leakage of filtrate increased interstitial pressure blockage of tubules by sloughed tubular cells and protein

    11. Acute tubular necrosis (ATN) Ischemic Sepsis Heart failure Massive burns Crush injuries Transfusion reactions Peripartum hemorrhage

    12. Nephrotoxic ATN: exogenous non-therapeutic toxins organic solvents (ethylene glycol) halogenated hydrocarbons (CCL4) heavy metals insecticides recreational drugs

    14. Nephrotoxic ATN Endogenous toxins Uric acid Calcium oxalate Myoglobin/hemoglobin Light chains (Bence Jones proteins in multiple myeloma)

    19. Nephrotoxic ATN Therapeutic toxins antibiotics (aminoglycosides, cephalosporins, tetracylines, amphotericin) NSAIDS COX-2 IV contrast dye Lithium ACE/ARB in volume depletion chemotherapeutic agents (cis-platinum, methotrexate) immune suppressants: cylosporine

    26. Tubulointerstitial nephritis Infection Drugs Systemic diseases Immune related

    27. Acute pyelonephritis

    31. Defenses against urinary tract infections Emptying bladder Washing action of micturition Antibacterial properties of urothelium Immunity

    38. Vesicoureteral reflux

    42. Chronic pyelonephritis

    46. Analgesic nephropathy

    51. Urate nephropathy

    55. Myeloma kidney

    59. Nephrocalcinosis

    60. Immune-related tubulointerstitial disease

    61. Allergic drug reactions Sulfonamides Beta-lactam antibiotics Thiazides NSAIDS Penicillamine, gold salts Captopril

    64. Renal sarcoid

    66. Tubulointerstitial disease of the KIDNEY

More Related