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Kidney Disease. 7.7. Urinalysis. Diabetes Mellitus. Normal: 0.1 % blood sugar can be reabsorbed. Diabetes Mellitis : Inadequate secretion of insulin Blood sugar levels tend to rise. Excess sugar remains in nephron .
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Kidney Disease 7.7
Diabetes Mellitus • Normal: • 0.1 % blood sugar can be reabsorbed. • Diabetes Mellitis: Inadequate secretion of insulin • Blood sugar levels tend to rise. • Excess sugar remains in nephron. • Osmotic pressure in nephron water remains in nephron and lost with urine. • Affected usually void large volumes of urine: need to drink more water.
Diabetes Insipidus • Destruction of ADH-producing cells or nerve tracts b/n hypothalamus and pituitary gland. • No ADH no reabsorption increase in very dilute urine
Bright’s Disease • Also called nephritis • Caused by inflammation of nephrons(many ways) • Toxins produced by invading microbes destroy glomerulus vessels proteins and other large molecules able to pass into nephron. • Proteins (no reabsorption): remain in nephron and create osmotic pressure, drawing water into nephron.
Kidney Stones • Precipitation of mineral solutes from blood. • Two groups: alkaline and acid stones. • Sharp stones lodge in renal pelvis ureter urethra. • Can tore delicate tissues.
Treatment of Kidney Stones • Surgical removal (old technique) • New technique: Extracorporeal shock-wave lithotripsy (ESWL) • Nonsurgical technique: high-energy shock waves to break kidney stones into smaller peices. • Tiny granules can be voided in excretory system.
Dialysis Technology • Dialysis: exchange of substances across a semipermeable membrane. • Operates of principles of diffusion and blood pressure • Cannot perform active transport. • Two kinds of dialysis • Hemodialysis • Machine connected to circulatory system by a vein • Blood pumped through dialysis tubes in a bath of various solutes • Urea and other waste solutes continually removed. • Also receives hormones the kidneys can not produce. • Peritoneal dialysis • 2 L of dialysis fluids pumped into abdominal cavity, urea and other wastes diffuse from plasma into dialysis fluid. • Drained off and replaced several times a day.
Kidney Transplants • Nothing can surpass the workings of a working kidney. • Today, transplant is 85% effective. • Immune system can reject new kidney. • New kidney attached to blood vessels and bladder in the lower abdomen. Old kidney not removed unless chronically infected/inflamed.
Seatwork/Homework • Page 362, #1-8