NSF-NSEC for Integrated Nanopatterning and Detection Technologies

1. 2 nm Integrated chip-based detection system The authors thank the National Science Foundation for support of this work. NSF-NSEC for Integrated Nanopatterning and Detection Technologies (NSEC Grant Number EEC – 0647560) Chad Mirkin (PI), Michael Bedzyk, VinayakDravid, Horacio Espinosa, Franz Geiger, Mark Hersam, Joseph Hupp, SonBinh Nguyen, Monica Olvera de la Cruz, George Schatz, Richard Van Duyne, William Klein, Chang Liu, Milan Mrksich, Steve Sligar, Teri Odom, Steve Wolinsky, Laurie Zoloth, Mercouri Kanatzidis, Jiaxing Huang, C. Shad Thaxton Northwestern University, University of Chicago, University of Illinois at Urbana-Champaign Ac-GXKAcZGC-NH2 Detector X Position D N E Q K R H S T M W F Y V I L A G P Alkanethiolate D N E MS Q Alkyldisulfide K R Z Position H S T M m/z W F Y V I L A G P Education and Outreach SRG 1: Nanopatterning 0 1 Research Experience for Undergraduates Research Experience for Teachers Partnership with the Museum of Science and Industry, Chicago • Resulting in 2,400 square ft permanent exhibit on nanotechnology • Opening 2011 • Potential to reach over 2 million visitors per year • DiscoverNano Website(www.discovernano.northwestern.edu) • >900,000 visitors a year • Includes: • Introduction to nanotechnology • Historical timeline • Nano Art gallery • Curriculum projects • Meet the Researchers section Nanotechnology Town Hall Meetings • Introduces nanotechnology to the public • Addresses societal/ethical concerns • 7 meetings held, ~600 attendees to date • Nanoscience Pre-college Module • Inquiry-based, links to real-world applications, extensively field-tested • Includes student & teacher manuals • Being disseminated world-wide by NCLT • 208 REU participants to date • 50% of participants women and underrepresented minorities • Hands-on research plus professional development activities • Technical writing course • Public Speaking workshop • Tour of Argonne National Laboratory • Final symposium and written paper • Over 90 published papers • Program includes hands-on research and curriculum development for their classrooms • 81 pre-college teachers have participated to-date • ~9000 pre-college students impacted to-date Dip-Pen Nanolithography Feedback Controlled Lithography Heteromolecular 10 million Pen ArrayIntermolecular spacing with atomic precision Nanostructures Knowledge Transfer (to-date) • 726 publications • 193 provisional patents • 1,444 domestic and international seminars & colloquia • 97 Frontiers in Nanotechnology Seminars • 7 International Institute for Nanotechnology Symposiums • 16 start-up companies launched through Small Business Evaluation & Entrepreneur’s (SBEE) Program (>$500M in VC invested) • 20 companies enlisted in Nanotechnology Corporate Partners (NCP) program • 70 Industrial partnerships • 47 International partnerships Nanoscape: The Journal of Undergraduate Research in Nanoscience • 93 articles published to date • Undergraduate authors from institutions across the country • Volume VIII to be released Summer 2011 • On-line and print version • Print version mailed to >1,000 college and university departments and libraries Polymer Pen Lithography 2-D Active Probe Arrays Parallel Inking Wells SRG 2: Signal Transduction & Receptor Design SRG 3:Integrated Biodetection Chip MOSFET-embedded microcantilever development Surface immobilized bio-barcode assay Improved bio-barcode assay Flow 250 nm Aperture Lamp Spectrometer Flow cell Protein biomarker identification New Receptor Chemistries Detection Strategies Enabled by NanoMaterials Profiling HDAC Activity Drug Binding to Membrane Proteins Measuring Telomerase Activity Integration of novel receptors with nanomechanical detection platform