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PROGRESSIVE CENTRALIZATION OF MIDBRAIN HYPERACTIVITY AFTER ACOUSTIC TRAUMA

PROGRESSIVE CENTRALIZATION OF MIDBRAIN HYPERACTIVITY AFTER ACOUSTIC TRAUMA. W. H. A. M. MULDERS* AND D. ROBERTSON Presenter: Danyi LU Neuroscience 192 (2011) 753–760. what's new. spontaneous firing rates (SFRs). Acoustic trauma Central hyperactivity

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PROGRESSIVE CENTRALIZATION OF MIDBRAIN HYPERACTIVITY AFTER ACOUSTIC TRAUMA

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  1. PROGRESSIVE CENTRALIZATION OF MIDBRAIN HYPERACTIVITYAFTER ACOUSTIC TRAUMA W. H. A. M. MULDERS* AND D. ROBERTSON Presenter: Danyi LU Neuroscience 192 (2011) 753–760

  2. what's new spontaneous firing rates (SFRs) Acoustic trauma Central hyperactivity Early stage: continued peripheral afferent input Later stage: intrinsically generated within the central nervous system Abbreviation: spontaneous firing rates -SFRs inferior colliculus -IC central nucleus of the inferior colliculus -CNIC compound action potential-CAP

  3. EXPERIMENTAL PROCEDURES overall experimental design

  4. EXPERIMENTAL PROCEDURES 1.animals 2.anesthesia and surgery 3.inferior colliculus recording* 4.cochlear ablation 5.data analysisi

  5. RESULTS-Cochlear thresholds

  6. RESULTS-Cochlear thresholds

  7. RESULTS-Summary of all data

  8. RESULTS-Hyperactivity in CNIC

  9. RESULTS-Effects of cochlear ablation on hyperactivity

  10. RESULTS-Comparison with shorter recovery data

  11. RESULTS-elevatedSFRs in CNIC neurons after acoustic trauma were morecommonly observedin CF regions of the CNIC that correlatewith the frequencies in the cochlea

  12. Discussion-differential effect of cochlearablation at the two stages

  13. Significance Important consequences for possible mechanisms and treatment of tinnitus Recent-onset Tinnitus Long-standing Tinnitus

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