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Overwhelming fungal infection in a Toll deficient background

Overwhelming fungal infection in a Toll deficient background. Leucine rich domains. Toll. TIR domain. NF- k B. NF- k B. Comparison of structures of CD14, Toll and IL-1R. Leucine rich domains. Ig-like domains. IL-1R. CD14. GPI anchor. Cell membrane. TIR domain.

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Overwhelming fungal infection in a Toll deficient background

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  1. Overwhelming fungal infection in a Toll deficient background

  2. Leucine rich domains Toll TIR domain NF-kB NF-kB Comparison of structures of CD14, Toll and IL-1R Leucine rich domains Ig-like domains IL-1R CD14 GPI anchor Cell membrane TIR domain

  3. Nature, Vol 388, 24 july 1997, 394-397

  4. Bruce Beutler

  5. Toll-like receptors ssRNA IMQ CpG IMQ dsRNA Flagellin LPS Zym, LP PG, LP LP 1 2 3 4 5 6 7 8 9 10

  6. Modèle proposé Complexe ternaire : 1 homodimères + ARNdb Permet le chevauchement des TIR engageant la signalisation.

  7. Spaetzle TLR ProSpz IL-1 IL-1R NF-kB IL-1 NF-kB Drosomycin Mammals NF-kB Defensin Drosophila Parallels between IL-1 and Spz functions Microbial inducers PGRP-SA GNBP-1 Toll

  8. Sang

  9. hKIR TREM Ig-SF NCR m PIR h LIR (ILT) NKRP-1 mLY49 NKG2D C-type Lectins Mannose Rec. (MR, Endo180, DEC205, PLA2R) DC-SIGN receptors Dectin-2 (NCCL) Langerin BDCA-2 (DLEC) TLR Others (LRR, CARD,…) NOD molecules TLR

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