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SUPERFICIAL FUNGAL INFECTION DERMATOPHYTOSIS. THREE GENERA KNOWN TO CAUSE DISEASE -TRICOPHYTON - MICROSPORUM - EPIDERMOPHYTON. EPIDEMIOLOGY.
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SUPERFICIAL FUNGAL INFECTION DERMATOPHYTOSIS THREE GENERA KNOWN TO CAUSE DISEASE -TRICOPHYTON - MICROSPORUM - EPIDERMOPHYTON
EPIDEMIOLOGY • GEOPHILIC - – M.GYPSEUM – M. FERRUGINEUM - T. TERRESTRE - T.VIOLACEUM • ZOOPHILIC - - M. CANIS – CAT, DOGS,SHEEPS - T. EQUINUM – CATS, DOGS,CATTLES - T. VERRUCOSUM – CATS , DOGS, CATTLES,SHEEPS • ANTHROPOPHILIC - -E. FLOCCOSUM –M. AUDOUINII –T. MENTAGROPHYTES –T. RUBRUM – T. TONSURANS –
PATHOGENESIS • FUNGI MUST OVER COME - EFFECT OF UV LIGHT –TEMPERATURE VARIATION – COMPITION WITH NORMAL FLORA -FUNGISTATIC AGENTS – • FATTY ACIDS,SPHINGOSINES • - EPIDERMAL GROWTH • DTH IMMUNE RESPONSE
TINEA BARBAE • INFAMATORY TYPE- T. MENTAGROPHTE, T. VERRUCOSUM • SUPERFICIAL TYPE - ANTHROPOPHILIC –T. VIOLACEUM,T.RUBRUM • CIRCINATE TYPE
TINEA PEDIS • CHRONIC INTERTRIGINOUS TYPE • CHRONIC HYPERKERATOTIC TYPE • VESICULOBULLOUS TYPE • ACUTE ULCERATIVE TYPE
TREATMENT SYSTEMIC THERAPY TOPICAL THREAPY **
SYSTEMIC ANTIFUNGALS • ALLYLAMINS – • INHIBITS SQUALENE EPOXIDASE BLOCKING BIOSYNTHESIS OF ERGOSTEROL • FUNGICIDAL • 3 TO 6 mg/kg OD • CONTRAINDICATED IN PREGNANCY & LACTATION • TRIAZOLES – ITRACONAZOLE, FLUCONAZOLE INHIBIT 14 alfa DEMETHYLASE ENZYME IN CELL MEMBRANE USEFUL FOR CONVERSION OF SQUALENE TO ERGOSTEROL . IMIDAZOLE – KETOCONAZOLE GRISEOFULVIN – DISRUPS MICROTUBULE MITOTIC SPINDLE FORMATON THUS ARREST MITOTIC AT METAPHASE STAGE
TREATMENT TOPICAL -ALLYLAMINES – TERBINAFINE,NAFTIFINE -BENZYLAMINE - BUTENAFINE -IMIDAZOLES CLOTRIMAZOLE, MICONAZOLE, KETOCONAZOLE -TOLNAFTAE