1 / 7

Matrix Metalloproteins (MMPs)

Matrix Metalloproteins (MMPs) . How Zn2+ is involved in the catalytic domain and how it can be inhibited. What are MMP’s?. Pro-domain catalytic domain . Similarities/differences between catalytic & pro domains of MMPs. How are MMP’s involved in disease?. Mechanism.

cheche
Download Presentation

Matrix Metalloproteins (MMPs)

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript


  1. Matrix Metalloproteins (MMPs) How Zn2+ is involved in the catalytic domain and how it can be inhibited.

  2. What are MMP’s? • Pro-domain • catalytic domain Similarities/differences between catalytic & pro domains of MMPs

  3. How are MMP’s involved in disease?

  4. Mechanism

  5. How was this structure discovered? • XANES (X-Ray Absorption Near-edge Structure) • Zn2+ coordination • Different pH • Mutating active site residues These people don’t consider the enzyme in its inactive state, ie. cysteine switch.

  6. How is the active site inhibited? • Understanding the catalytic domain leads to an understanding of how it is inhibited. • And here’s how… • How the Zn coordination is altered ***Focus on techniques used small molecule screening for development of drugs TIMPs

  7. Future Endeavours • Why does deletion of different MMPs cause a variety of phenotypic mutations?

More Related