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Design of Completed Perinatal Trials

Design of Completed Perinatal Trials. AP. IP. PP (baby, mother or both). 14 wks. 28 wks. 36 wks. 3d to 1 wk. 6 wks. 076. NonBF. Thai (Harvard). NonBF. Thai (Harvard). NonBF. Thai (Harvard), BMS. NonBF. IvC (ANRS), PETRA, Thai (Harvard). BF/NonBF.

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Design of Completed Perinatal Trials

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  1. Design of Completed Perinatal Trials AP IP PP (baby, mother or both) 14 wks 28 wks 36 wks 3d to 1 wk 6 wks 076 NonBF Thai (Harvard) NonBF Thai (Harvard) NonBF Thai (Harvard), BMS NonBF IvC (ANRS), PETRA, Thai (Harvard) BF/NonBF Thai (CDC), IvC (CDC) NonBF/BF PETRA,012, SAINT BF PETRA BF Wade (observational) NonBF

  2. Design of Ongoing/Planned Infant Prophylaxis Trials AP IP PP infant 34 wks 36 wks 1 wk 4 wks 6 wks 6 mo 3d PP infant regimen Botswana (Harvard) AZT +/- NVPx1 SIMBA AZT/DDI + NVP vs 3TC HPTN 046 NVP (daily) vs NVPx1 Ethiopia/India NVP(daily) vs NVPx1 NICHD/HPTN 040(Brazil) AZT vs NPV; AZT vs AZT + NVPx3 vs AZT + 3TC/NFV 2wk Thai (CDC) AZT + NVPx1 Thai (Harvard)/ AZT +/- NVPx1 Ivory Coast (ANSR) AZT + NVPx1 Malawi NVPx1 vs NVPx1 + AZT Zambia (Harvard) South Africa HIVNET 024 Uganda Zambia (UAB/PAF)/ HPTN 054 NVPx1+EBF abrupt vs routine wean; NVPx1+EBF NVPx1 + AP/IP antiobiotics vs no antibiotics NVPx1 vs NVPx1 + HIVIG +/- VCT NVPx1

  3. Design of Maternal HAART Prophylaxis Trials PP maternal regimen AP IP PP Mother ?? wks 36 wks 6 mos ?? mo Botswana (Harvard) AZT/3TC/NVP? MTCT-Plus AZT/3TC/NFV? Kenya (CDC) HAART x 6 months AZT/3TC/NFV (?) vs NVP infant x 6 mos vs NVPx1 + nutrition Malawi (CDC/UNC) Cameroon (EGPAF) HAART during BF Multisite Africa (WHO) AP if CD4> 200: AZT VS HAART; IP: ZDV vs HAART PP: NO ARV vs HAART

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